Matthew J Shepherd
Postdoc at the University of Manchester, with Prof. Mike Brockhurst. Understanding and predicting the evolution of antimicrobial resistance in clinical Pseudomonas 🔬🦠
- Reposted by Matthew J Shepherd🚨 Fully‑funded PhD for Home Students🚨 We'll explore non-antibiotic alternatives in relatistic environments, uncovering how they work, if they affect antibiotic activity and whether they influcence AMR acquistion. Come join a wonderful supervisory team! #MicroSky #UTISky #AMar tinyurl.com/38u552bu
- Reposted by Matthew J ShepherdI feel like America plotting to annex Greenland while masked state goons terrorise their own communities at will should encourage British press and politicians to reflect on what happens when you act like "far right" is an unfair slur rather than a necessary descriptor of a real political position.
- Reposted by Matthew J ShepherdSo excited to have @szytynska.bsky.social kicking off our Evolution & Ecology day at @manchester.ac.uk today! #UoM_EEday
- Reposted by Matthew J Shepherd@bexlowrypalms.bsky.social up next speaking about her work on bdellovibrio #UoM_EEday
- Reposted by Matthew J ShepherdMassive congratulations to our own @magdalenakurteu.bsky.social for winning the poster prize at #MicroEvo25!! Her poster describes coalescence dynamics in hot spring microbial communities, and featured wonderful photos from Icelandic field work
- Reposted by Matthew J ShepherdIncredibly insightful talk this afternoon by @matthewjshepherd.bsky.social speaking about within-patient ciprofloxacin resistance in P. aeruginosa #MicroEvo25
- Reposted by Matthew J Shepherd[This post could not be retrieved]
- Reposted by Matthew J ShepherdNew work from @colomer-winter.bsky.social shows that E. faecalis doesn’t wait for mutations at all - it immediately rewires its membrane lipids as a stress response to daptomycin. And surprisingly, the cell ends up looking a lot like a resistant strain before any genetic change happens.
- Reposted by Matthew J Shepherd🚨#PhD studentship opportunity! Plasmids provide bacteria with antimicrobial resistance, but do they have more fundamental effects on behaviour? 🧫🦠💫🧟♂️ Apply for a 4y funded MRC DiMeN position with me and Jamie Wheeler @livuni-ives.bsky.social www.findaphd.com/phds/project...
- Reposted by Matthew J ShepherdWe have a new preprint modeling the regulatory networks of efflux pumps to predict the evolution of multidrug resistance in P. aeruginosa. Also explore cross-resistance, collateral sensitivity & loss of resistance. With @suvamroy.bsky.social @elibbyscience.bsky.social www.biorxiv.org/content/10.1...
- Reposted by Matthew J ShepherdSharp global rise in antibiotic-resistant infections in hospitals, WHO finds
- Reposted by Matthew J Shepherd100k and rising! This number will continue to grow. Making hope normal again. Join us. join.greenparty.org.uk
- Reposted by Matthew J ShepherdOn the biological meaning of the population pangenome
- Reposted by Matthew J ShepherdThe evolutionary foundations of transcriptional regulation in animals www.nature.com/articles/s41... (read free: rdcu.be/evDcA) 🧬🖥️🧪
- Reposted by Matthew J ShepherdThe evolution of high-order genome architecture revealed from 1,000 species www.biorxiv.org/content/10.1... 🧬🖥️🧪 github.com/xjtu-omics/H...
- Reposted by Matthew J ShepherdTissue destruction during food spoilage is associated with the formation of biofilms by Pseudomonas species biorxiv.org/content/10.1101/202…
- Reposted by Matthew J ShepherdPatterns of compensatory mutations in rpoA/B/C genes of multidrug resistant M. tuberculosis in Uganda biorxiv.org/content/10.1101/202…
- Reposted by Matthew J Shepherd1/27 We have a new paper out! Turns out that snowflake yeast have been hiding a secret from us - they've evolved a (very!) crude circulatory system. Not with blood vessels or a heart, but through spontaneous fluid flows powered by their metabolism. 🧪🔬 www.science.org/doi/full/10....
- Reposted by Matthew J ShepherdHigher-order epistasis drives evolutionary unpredictability toward novel antibiotic resistance biorxiv.org/content/10.1101/202…
- Reposted by Matthew J ShepherdA few hours left for you to sneak in a cheeky last minute abstract! ECRs, you know what to do… #mevosky
- One week left to submit your abstract to @microbiologysociety.org meeting on “Understanding and Predicting Microbial Evolutionary Dynamics” at Liverpool 26-27 November Lots of spaces for ECR talks and posters! microbiologysociety.org/event/societ...
- Reposted by Matthew J ShepherdFresh from peer review a new and improved version of @taoranfu.bsky.social’s paper out today in @asm.org mSystems journals.asm.org/eprint/8NWNW...
- A nice way to wrap-up 2024: a neat preprint by @taoranfu.bsky.social (hot on the heels of her successful PhD viva) testing how inflammation-like environments shape Pseudomonas adaptation, limiting loss of quorum sensing www.biorxiv.org/content/10.1...
- Reposted by Matthew J ShepherdGo Team! Deeply honoured that the MERMan lab reps won an @manchester.ac.uk "FMBH heroes" award - thanks @fbmh-uom.bsky.social and @mermanchester.bsky.social for nominating us ❤️❤️❤️
- Reposted by Matthew J ShepherdCurious about plasmid biology? Our latest paper is out now in Nature Communications! 🚨 doi.org/10.1038/s414... We analyzed thousands of diverse bacterial plasmids to shed light for the first time on a key aspect of plasmid biology: plasmid copy number. 1/7 👇
- Reposted by Matthew J Shepherd📣 Position available: Research tech in microbial experimental evolution! Working alongside postdoc Louise Flanagan (@flanagella.bsky.social) on understanding how Pseudomonas evolves resistance to antibiotics. 🦠🧫 Closing 9 July #Microsky www.jobs.manchester.ac.uk/Job/JobDetai...
- Reposted by Matthew J ShepherdMystique is here! When I started my position at @cmdi.bsky.social there were no readily available phage against my A. baumannii focal strain. The solution? Finding my own phage ofc. Mystique is a broad host range Acinetobacter phage, and I'm thrilled to see this work out today #PhageSky 🧪🦠
- Reposted by Matthew J ShepherdWe're on a mission to #KeepAntibioticsWorking for generations to come, but we need your help @profkevinfenton.bsky.social, @fphuk.bsky.social, tells us why this is such an important mission 📅 Join us on 7 April to learn exactly what steps you can take to help tackle this growing health challenge
- Reposted by Matthew J ShepherdDelighted to have won a poster prize at #microbio25 this week! Had a really great time at this conference, learned so much and met so many old (and some new!) faces. Thanks so much to the organisers for a great event and to the society for the travel grant too! 🚝🧪🦠
- - Journal of General Virology poster prize winner: Afifah Tasnim @afifahtasnim.bsky.social -Microbiology poster prize winner: Louise Flanagan @flanagella.bsky.social
- Reposted by Matthew J ShepherdThe MERMan contingent at #microbio25 headed home today after a great week in Liverpool for the @microbiologysociety.org annual conference - Thanks to the society and organisers for putting on a great event, and supporting us in presenting 6 talks and 5 posters packed full of microbial evolution!
- Reposted by Matthew J Shepherd@brockhurstlab.bsky.social giving a talk about eco-evolutionary mechanisms of AMR in the AMR session at #Microbio25
- Reposted by Matthew J ShepherdTo all enjoying #MicroBio25 remember: all @microbiologysociety.org events rely on our journals - every paper pays 4x travel grants! Make 2025 when you submit a paper to a MicroSoc journal www.microbiologyresearch.org $0 OA for Publish+Read institutions www.microbiologyresearch.org/publish-and-...
- Reposted by Matthew J ShepherdHad a fab time presenting a flash talk at #microbio25 in the urogenital microbes session this afternoon. If you love a good biofilm or polymicrobial communities and want to find out more, I'd love to chat at my poster tomorrow - B086 👩🏼🏫 @microbiologysociety.org
- Nice talk by @dralhubb.bsky.social at #microbio25. Urobiome as a possible reservoir of AMR for UTIs, including HGT and selection of spontaneous mutants!
- Reposted by Matthew J Shepherd@matthewjshepherd.bsky.social talking about clinical PA in chronic lung infection suggesting picking 10~20 colonies is pretty good for diagnosing pre-existing AMR #Mircobio25
- Reposted by Matthew J ShepherdIn addition to @brockhurstlab.bsky.social @matthewjshepherd.bsky.social 's upcoming talks in the AMR session today, we have many @mermanchester.bsky.social posters on display! Come learn from our talented scientists about evolution, AMR, and microbiomes #microbio25
- Looking forward to speaking in the AMR mechanisms and regulation session at #Microbio25 today. I'll be speaking right after @brockhurstlab.bsky.social who will discuss our within-patient resistance evolution project, and I'll outline some measures we can take against resistance evolution in-host
- Absolute treat to see @relenski.bsky.social tell the story of 37 years of science and evolution at #microbio25, a proper 'conference bucket list' moment for me, reading the LTEE story as an undergrad definitely motivated me to get into experimental evolution!
- Great talk on the rising issue of biocide tolerance by Vicky Bennet in the AMR mechanisms and regulation session - multiple mutations from evolution experiments of Proteus mirabilis match those seen in clinical isolates!
- Great talk by @mermanchester.bsky.social member @whelanfj.bsky.social at Microbiology Society annual conference - insights on 600 cumulative years of P. aeruginosa within-patient evolution by the prairie epidemic strain! 🤯
- Reposted by Matthew J ShepherdFrench researcher, going to a conference in Houston, was forbidden entry to US; his work and personal electronics were both confiscated. Why? Because a “random search” of his cell phone revealed a negative personal opinion on Trump and the Trump administration. www.lemonde.fr/internationa...
- Reposted by Matthew J ShepherdIn our latest Editorial we discuss the continuing damage being done to US science, and its impact on researchers and the environment 👇 Deep cuts: www.nature.com/articles/s41...
- Reposted by Matthew J ShepherdThey are talking about going back to *already awarded grants* and canceling them, or slashing the budget of them, for doing the *legally mandated* broader impacts.
- Reposted by Matthew J ShepherdI think this hasn't gotten as much attention as it should. Please look at this Executive Order, read what it says about grants, and think about what this means for scientific grants. www.whitehouse.gov/presidential...
- Reposted by Matthew J ShepherdAre you serious @royalsociety.org?? He is trying to destroy science, spreading dangerous misinformation, inciting violence & your response is to do nothing? So what’s your purpose then? What do you exist for? Other than being elite? 🧪 #academicsky www.theguardian.com/technology/2...
- Reposted by Matthew J Shepherd🇪🇺🇬🇧 Through my first set of meetings in Brussels. The praise for Starmer is overwhelming: “What he has managed to do is not just good for him. It's good for all of us. Absolutely top notch. This is the UK at its best. The UK we have always admired.
- Reposted by Matthew J Shepherd@biorxivpreprint.bsky.social servers have been slow lately. Which reminds me: do we have backups that are located on non-US servers? We shouldn’t give away the information war without resistance…
- Reposted by Matthew J ShepherdThey've done something on the main NIH[dot]gov page to redirect the search results back to the main page. I tried with "gender" as test and "cat" as control. A normal search should show a page of search results, but when I search "gender" the screen flashes and I see the homepage again.
- Reposted by Matthew J ShepherdReported on LinkedIn: Searching NIH homepage for “diversity,” equity", "inclusion," "gender," "racism," or "transgender" yields no results. Can others confirm?
- Reposted by Matthew J ShepherdRemember, EuropePMC is actually better than #PubMed because it includes ALL preprints in search results, not just those including NIH-funded research. europepmc.org
- Reposted by Matthew J Shepherd📣New review revisits Fleming’s caveat about antibiotic misuse and #AMR. Decisions by healthcare professionals, policymakers, pharmaceutical companies, & patients have all shaped AMR. Coordinated action is needed to solve it. From Mato Lagator, @dannagifford.bsky.social and coauthors. doi.org/n8z7
- Reposted by Matthew J ShepherdThis is a promising development. Europe should be standing for freedom, perhaps against global odds right now, as we have too much history to remind us of what happens if we do not.
- Reposted by Matthew J ShepherdMerz just said on German TV that the primary priority of his government will be to ensure that Europe can achieve full strategic independence from the United States in the defence against Russia. Merz was once a die hard Atlanicist. Now, after Trump he is a Gaullist. Extraordinary.
- Reposted by Matthew J Shepherd🎉 Congratulations to Dr Rowan Green, who defended his PhD today! @rowancallumg.bsky.social
- Reposted by Matthew J Shepherd[This post could not be retrieved]
- Reposted by Matthew J ShepherdScientists are now organizing events, called Stand Up for Science, on 7 March in Washington, D.C., and state capitals. So far, they have attracted more than 100 volunteers from some 30 states who are hoping to rally support for research as a public good. scim.ag/4328LAD
- Reposted by Matthew J ShepherdThis is not news to most scientists by now, but others might be interested. Biomedical research is undergoing tremendous damage, even beyond the firings at NIH, CDC, and NSF; the suppression of data sharing; and the attacks on initiatives to improve scientific quality.
