- Why does daptomycin resistance appear so fast in Enterococcus? We finally have a clue. DAP resistance in enterococci pops up quickly. What’s been missing is why resistance-associated membrane changes look the way they do, and why the classic path of mutations is so predictable.
- A two-component system signaling hub controls enterococcal membrane remodeling in response to daptomycin biorxiv.org/content/10.1101/202…
- New work from @colomer-winter.bsky.social shows that E. faecalis doesn’t wait for mutations at all - it immediately rewires its membrane lipids as a stress response to daptomycin. And surprisingly, the cell ends up looking a lot like a resistant strain before any genetic change happens.Nov 17, 2025 20:27
