Paula Ramiro-Martínez
Predoctoral researcher at evodynamics lab in Madrid.
Bacterial and plasmid evolution 🫧🧬💻
- Reposted by Paula Ramiro-Martínez🧬New paper out! We report the first isolation of viable B. bacteriovorus predators from human gut microbiota. www.frontiersin.org/journals/mic.... Great work of Mario Romero @migueldiezfdz.bsky.social @josete600.bsky.social and @rosacampo.bsky.social
- Reposted by Paula Ramiro-MartínezIn this issue: Fresh light on horse evolution, mangrove restoration as coastal flood protection, and the links between aerobic metabolism and planetary oxygenation. In PNAS: ow.ly/yB6J50Y5ykK
- Reposted by Paula Ramiro-MartínezAnd what a beautiful @pnas.org cover @paularamiro.bsky.social and @jerorb.bsky.social !!!!!! You should be very proud!
- New paper out in @pnas.org, and it made the cover! 👁️ We represent plasmids as circles and mutations as dots, resembling an eye, because in this paper we literally 𝑤𝑎𝑡𝑐ℎ plasmids evolve. ‼️Check Paula’s 🧵 and the paper👇 𝗣𝗹𝗮𝘀𝗺𝗶𝗱 𝗺𝘂𝘁𝗮𝘁𝗶𝗼𝗻 𝗿𝗮𝘁𝗲𝘀 𝘀𝗰𝗮𝗹𝗲 𝘄𝗶𝘁𝗵 𝗰𝗼𝗽𝘆 𝗻𝘂𝗺𝗯𝗲𝗿 www.pnas.org/doi/10.1073/...
- Reposted by Paula Ramiro-MartínezSo great to finally have such a clear answer to this question!! Well done guys!
- New paper out in PNAS!!! 🎉 Do more plasmid copies mean faster evolution? 🧵 Dive into the story www.pnas.org/doi/10.1073/...
- Reposted by Paula Ramiro-MartínezNew paper out in @pnas.org, and it made the cover! 👁️ We represent plasmids as circles and mutations as dots, resembling an eye, because in this paper we literally 𝑤𝑎𝑡𝑐ℎ plasmids evolve. ‼️Check Paula’s 🧵 and the paper👇 𝗣𝗹𝗮𝘀𝗺𝗶𝗱 𝗺𝘂𝘁𝗮𝘁𝗶𝗼𝗻 𝗿𝗮𝘁𝗲𝘀 𝘀𝗰𝗮𝗹𝗲 𝘄𝗶𝘁𝗵 𝗰𝗼𝗽𝘆 𝗻𝘂𝗺𝗯𝗲𝗿 www.pnas.org/doi/10.1073/...
- New paper out in PNAS!!! 🎉 Do more plasmid copies mean faster evolution? 🧵 Dive into the story www.pnas.org/doi/10.1073/...
- We're thrilled that, in addition, our figure has been chosen as the cover for this issue of PNAS! 🥹🎉
- New paper out in PNAS!!! 🎉 Do more plasmid copies mean faster evolution? 🧵 Dive into the story www.pnas.org/doi/10.1073/...
- New paper out in PNAS!!! 🎉 Do more plasmid copies mean faster evolution? 🧵 Dive into the story www.pnas.org/doi/10.1073/...
- Plasmids face a paradox. 🔹 More copies = more mutational opportunities 📈 🔹 But random segregation = more drift, fewer fixations 📉 So, which force dominates as plasmid copy number (PCN) increases: more mutations or more losses? Let’s find out 🧬
- We modelled plasmid inheritance using a Cannings model and validated it with computational simulations 🧫 Each plasmid copy is like an evolutionary unit, randomly split at division, then copied. Prediction: Mutation rate increases with PCN, but with diminishing returns: a logarithmic rise.
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View full threadHuge thanks to all my brilliant co-authors 🙌 @nachodequinto.bsky.social, @laura-jaraba.bsky.social , Val F. Lanza, @crisherencias.bsky.social, Adrián González Casanova, @penamiller.bsky.social & @jerorb.bsky.social
- Reposted by Paula Ramiro-MartínezHere, we find that many Genomic islands have origins of transfer (oriT) mobilisable by conjugation, incl. known Pathogenicity & defense islands. iOriT use only an oriT for transfer by hitching on conjugative elements: they make abundant, diverse, ancient families of mobile genetic elements. See🧵
- Bacteria chromosomes contain Genomic Islands that provide virulence, antibiotic resistance, MGE-defence,... They transfer between cells, but the mechanism of most remains elusive. Here we explore the conjugative capacity of these mysterious Genomic Islands. www.biorxiv.org/content/10.6...
- Reposted by Paula Ramiro-MartínezBacteria chromosomes contain Genomic Islands that provide virulence, antibiotic resistance, MGE-defence,... They transfer between cells, but the mechanism of most remains elusive. Here we explore the conjugative capacity of these mysterious Genomic Islands. www.biorxiv.org/content/10.6...
- Reposted by Paula Ramiro-Martínez#NewResearch The long-term existence of diverse virulent phages within cultures of Escherichia coli and others challenges the virulent–temperate dichotomy and points to non-canonical phage lifestyles. #MicroSky 🦠 @peterdoug.bsky.social @emggroupucph.bsky.social www.nature.com/articles/s41...
- Reposted by Paula Ramiro-Martínez#NewResearch Diverse genomes of lytic phages are found in bacterial assemblies, challenging assumptions about the nature of the lytic lifestyle. #MicroSky 🦠 www.nature.com/articles/s41...
- Reposted by Paula Ramiro-Martínez🎁 Getting a paper acceptance right before Christmas break is one of the best feelings. 100% recommend. Happy holidays, everyone! 🎄✨
- Reposted by Paula Ramiro-MartínezA pleasure and an honour to have received this prestigious grant with my admired colleagues and friends @sanmillan.bsky.social and @asanchezlab.bsky.social . More about AMR under plasmid lens!. My sincere gratitude to @caixaresearch.bsky.social @microryc.bsky.social @esgem-sg.bsky.social
- Congratulations to you and your teams, @sanmillan.bsky.social, @asanchezlab.bsky.social and @tmcoque.bsky.social! We are thrilled to support your work and look forward to the impact your project will have. 👏💫
- Reposted by Paula Ramiro-MartínezA plasmid golden ratio? 🧬 Plasmid copy number ≈ 2.5% of chromosome size—consistent across bacterial species! pmc.ncbi.nlm.nih.gov/articles/PMC... @jerorb.bsky.social 🧪 #microbesky
- 🚨🚨New paper out in @natcomms.nature.com!! Come for the first large-scale analysis of plasmid copy number across species, stay for one of the most intriguing results of my lab: universal scaling laws in plasmid biology! 📈🧬 👉 www.nature.com/articles/s41...
- Reposted by Paula Ramiro-MartínezIn episode 337 TWiM explains a study that examines pathogen presence in ancient humans and concludes that zoonoses emerged 6500 years ago with the domestication of livestock, and determination of universal rules that govern plasmid copy number. This week's special guest: @markowenmartin.bsky.social
- Reposted by Paula Ramiro-MartínezThis work is finally published! 🥳🧬 Plasmids are associated with very variable fitness costs in their different bacterial hosts. But, what is the contribution of each of the plasmid-genes in these host-specific effects? Study led by @jorgesastred.bsky.social, @sanmillan.bsky.social and myself! 1/14
- Reposted by Paula Ramiro-MartínezOur new manuscript is out! A bit of everything cool: Plasmids ✅ Insertion Sequences ✅ AMR Evolution ✅ Microbial Communities ✅ Databases analyses ✅ Mathematical modeling ✅ See the scientific thread below of Jorge Sastre, who has brilliantly led this work with @palomarodera.bsky.social
- New paper out! 🔈🔈📣📣 Plasmids promote antimicrobial resistance through Insertion Sequence-mediated gene inactivation. Combining experimental and computational approaches, we unveil how two of the most prevalent bacterial MGE accelerate the evolution of AMR. 🧵👇🏻 www.biorxiv.org/content/10.1...
- Reposted by Paula Ramiro-MartínezNew paper out! 🔈🔈📣📣 Plasmids promote antimicrobial resistance through Insertion Sequence-mediated gene inactivation. Combining experimental and computational approaches, we unveil how two of the most prevalent bacterial MGE accelerate the evolution of AMR. 🧵👇🏻 www.biorxiv.org/content/10.1...
- Reposted by Paula Ramiro-Martínez🚨🚨 New paper in @narjournal.bsky.social! 🍾 Excludons are pairs of overlapping genes that block each other’s expression (basically, reverse operons). We built a tool to identify them in bacterial genomes using transcriptomic data, in an awesome collab led by Iñigo Lasa and Álvaro San Martín. 👇
- Reposted by Paula Ramiro-MartínezHad an amazing time at #FEMS2025 last week, where I presented our latest findings on collateral sensitivity mediated by beta-lactamases ☯️ Big thanks to everyone who came by! So proud of my colleagues for their brilliant talks and posters ✨
- Reposted by Paula Ramiro-MartínezDo plasmids evolve faster 🐇, slower 🐢, or just like chromosomes 🧬? In our new paper, we tackled this question using theory, simulations, bioinformatics, and experiments! 👇 Check out all the details in Paula’s thread! Hint: 🐇 (most of the time)
- Reposted by Paula Ramiro-MartínezThe must-read of this Summer! 🤩 Congrats to all the authors for this beautiful work 🥳
- New paper alert! 🚨 Plasmids promote bacterial evolution through a copy number-driven increase in mutation rate. We combine theory, simulations, experimental evolution, and bioinformatics to demonstrate that mutation rates scale with plasmid copy number. Let's dive in! 🧵👇
- Plasmids face opposing evolutionary forces: 🔹 More copies = more chances to mutate 📈 🔹 But random segregation = drift, purging mutations 📉 So mutation supply ↑ with PCN, but the probability of fixation ↓ Which force dominates: the boost in mutation rate or the loss from segregational drift?
- We modelled plasmid inheritance using a Cannings model and validated it with computational simulations 🧫 Each plasmid copy is like an evolutionary unit, randomly split at division, then copied. Prediction: the mutation rate rises with PCN, but with diminishing returns, increasing logarithmically.
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View full threadThirty days of evolution… totally worth it! 🥹
- Reposted by Paula Ramiro-MartínezPlasmids promote bacterial evolution through a copy number-driven increase in mutation rate biorxiv.org/content/10.1101/202…
- Reposted by Paula Ramiro-MartínezThis is a legitimately incredible result that hints at something fundamental about plasmids that we don’t yet understand
- 🚨🚨New paper out in @natcomms.nature.com!! Come for the first large-scale analysis of plasmid copy number across species, stay for one of the most intriguing results of my lab: universal scaling laws in plasmid biology! 📈🧬 👉 www.nature.com/articles/s41...
- Reposted by Paula Ramiro-MartínezSuper proud of the lab for their outstanding presentations at #FEMS2025 in Milano! Science is better when you work with such a stellar team!🚀✨ @femsmicro.org
- Reposted by Paula Ramiro-MartínezIt was an honor and a joy to receive the National Research Prize for Young (!) Researchers. The highlight? My grandma greeting the King of Spain. What a day! www.youtube.com/watch?v=oSQP...
- Reposted by Paula Ramiro-MartínezOh this is fantastic 🦠🧫
- Curious about plasmid biology? Our latest paper is out now in Nature Communications! 🚨 doi.org/10.1038/s414... We analyzed thousands of diverse bacterial plasmids to shed light for the first time on a key aspect of plasmid biology: plasmid copy number. 1/7 👇
- Reposted by Paula Ramiro-MartínezIf you're into plasmid biology, you can't miss this back-to-back by two inspiring teams!
- 🚨🚨New paper out in @natcomms.nature.com!! Come for the first large-scale analysis of plasmid copy number across species, stay for one of the most intriguing results of my lab: universal scaling laws in plasmid biology! 📈🧬 👉 www.nature.com/articles/s41...
- Reposted by Paula Ramiro-Martínez🚨🚨New paper out in @natcomms.nature.com!! Come for the first large-scale analysis of plasmid copy number across species, stay for one of the most intriguing results of my lab: universal scaling laws in plasmid biology! 📈🧬 👉 www.nature.com/articles/s41...
- Curious about plasmid biology? Our latest paper is out now in Nature Communications! 🚨 doi.org/10.1038/s414... We analyzed thousands of diverse bacterial plasmids to shed light for the first time on a key aspect of plasmid biology: plasmid copy number. 1/7 👇
- First, we used DNA sequencing data to calculate and analyze the copy numbers of >6300 plasmids from different bacterial genera 💻. 2/7
- Our results revealed that although the copy number of natural plasmids is extremely diverse, it is robust against changes in genetic content and host 🦠. 3/7
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View full threadHuge thanks to this amazing team for all the hard work: @nachodequinto.bsky.social, João, Val and @jerorb.bsky.social 🫧 💪
- Reposted by Paula Ramiro-MartínezNew mini-review on the respiratory microbiome and its contribution to human health from biotechnology 🫁🦠 @tmcoque.bsky.social @microbiotech.bsky.social enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...
- Reposted by Paula Ramiro-MartínezHappy International Day of Women and Girls in Science 👩🔬🧬 #womeninscience #girlsinscience
- Reposted by Paula Ramiro-MartínezJust migrated here from twitter! Hello everyone. Also, I've just put up a super simple (and free) to use APP to streamline experiment design and result analysis of 96 (or 384) wells plate experiments for my lab pals. You can try it here: rosettier.streamlit.app Feedback is very welcome 😁!
