Leonhard Möckl
Professor of Nanooptical Imaging at FAU Erlangen-Nuremberg/CITABLE, Associated Group Leader at the MPI for the Science of Light. Glycobiology, optics, philosophy, and music.
- NEW PREPRINT: Spatial mapping of cell-surface protein glycosylation at molecular resolution 🍭🍬🔬 For the first time, we can analyze the spatial architecture of the cell-surface glycoproteome at single-protein and single-sugar resolution. #glycotime www.biorxiv.org/content/10.1...
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- Excited to see this one out in JACS! We analyzed how molecular interactions lead to self-organization of glycolipids down to microseconds and nanometer spatiotemporal scales. Amazing collaboration with the Sandoghdar lab, @biomemphys.bsky.social, and Thisbe Lindhorst! pubs.acs.org/doi/abs/10.1...
- Reposted by Leonhard MöcklRNA N-glycosylation enables immune evasion and homeostatic efferocytosis by chemically caging acp3U. Excited to report this work lead by Vinnie @vinnieviruses.bsky.social and in collaboration with @vijayrathinam.bsky.social in @nature.com www.nature.com/articles/s41...
- A more personal impression on our recent work on molecular resolution microscopy of the glycocalyx - check it out! #glycotime
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- Very happy to see this one out - the first molecular-resolution imaging of glycocalyx components in their native environment! Great collaboration with @jungmannlab.bsky.social - congrats to first authors @karimalmahayni.bsky.social and @lumasullo.bsky.social and to the whole team!
- Reposted by Leonhard MöcklBPS member Pernilla Wittung-Stafshede shares on the BPS blog about her decision to move from Sweden to the United States this year www.biophysics.org/blog/going-a...
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- GLYCAN ATLASSING: NANOSCALE ANALYSIS OF GLYCOCALYX ARCHITECTURE ENABLES FUNCTIONAL TRACING OF CELL STATE 🍭🔬🧬 Don’t judge a book by its cover - judge a cell by its cover! We can now trace how cell state is encoded in glycocalyx state. #glycotime #microscopy www.biorxiv.org/content/10.1...
- Reposted by Leonhard MöcklTreatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein - @raflynn5.bsky.social go.nature.com/3YbT1In
- A wonderful study, published today in Nature Biotech.: NPM1 is a marker of AML and can be targeted for efficient therapy! @karimalmahayni.bsky.social created the first SR reconstructions of NPM1 on the cell surface. Great collaborative work, spearheaded by @raflynn5.bsky.social and Kostas Tzelepis!
- Awesome study! 🙌
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- Happy and honored to be among the 2024 Rising Stars in Biological, Medicinal, and Pharmaceutical Chemistry - thanks to everyone who made it possible! tinyurl.com/fa3vyh5e We wrote a perspective on this occasion, discussing how to bring Physics and the Clinic closer together: tinyurl.com/mv7w2d74
- Reposted by Leonhard MöcklA nearly 9 year effort to design and implement new CLIP-based technologies to define multimeric protein assemblies on RNA. Enables ‘watching’ of RNP assemblies inside living cells Special congrats to Luca Ducoli, Brian Zarnegar, and Paul Khavari @nature.com www.nature.com/articles/s41...
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- Reposted by Leonhard MöcklNew findings from team led by Sophia Shi, @carolynbertozzi.bskyverified.social & Tony Wyss-Coray suggest that changes in the sugar coating on the blood-brain barrier may contribute to age-related cognitive decline and brain disease:
- It was wonderful to contribute to this amazing study! Congrats to @raflynn5.bsky.social and team - and congrats to @karimalmahayni.bsky.social for achieving the first SR reconstructions of csRBPs!:)
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- Reposted by Leonhard MöcklExited to announce our study on ER-Golgi Intermediate Compartment (ERGIC) in plants!! www.nature.com/articles/s41... Amazing and innovative work from @louisefougere.bsky.social and Magali Grison from @lbm-bordeaux.bsky.social, #SuperResolution, @naturecellbiology.bsky.social
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- Reposted by Leonhard MöcklCheck out our web tool for searching for interactors of your favorite cell surface protein, developed by undergrad Pinyu Liao and postdoc postdoc Brendan Floyd @stanford-chemh.bsky.social cellsurfacemap.org
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