Lori Passmore
Molecular biologist. Group leader at MRC LMB Cambridge UK. Fellow at Clare Hall college. #CryoEM #RNAbiology #DNArepair
Views/opinions are my own.
www2.mrc-lmb.cam.ac.uk/group-leaders/n-to-…
- Reposted by Lori Passmoreplus ... Ana Casañal Claudio Ciferri Hitoshi Kurumizaka Meindert Lamers David Rueda Yuanling Zhai Xiaodong Zhang 🧬🔬✨❄️ 🧫⚗️🧑🔬🏖️
- Reposted by Lori Passmore🌞✈️🇬🇷🏝️ 🧬 Machines on Genes 2026 🧬 🌞✈️🇬🇷🏝️ What an amazing list of speakers 🤩 @nynkedekkerlab.bsky.social @dodonova-sveta.bsky.social @yuanhejhu.bsky.social @uwmadisonrna.bsky.social @kowaeva.bsky.social @fmattiroli.bsky.social @aliciakmichael.bsky.social @lisaracki.bsky.social @yeeles-lab.bsky.social
- Reposted by Lori Passmore🔔 Register now and send an abstract! Lots of opportunities to talk! 👉 www.eventsforce.net/biochemsoc/f...
- Reposted by Lori Passmore8–11 June 2026 | 📍 Heraklion, Crete 🇬🇷 Get ready for Machines on Genes 2026, the 94th Harden Conference by the @biochemsoc.bsky.social — four days of molecular mechanisms and friendly discussions! 🧬☀️🔬❄️ Organised by @lapassmore.bsky.social, Dana Branzei, me.
- Reposted by Lori PassmoreSummer plans? Come join us in Crete to talk about “machines on genes” this June - what could be better?! ❤️ 🧬
- Alessandro Costa @costalaboratory.bsky.social, Dana Branzei and myself are co-organising the 2026 Machines on Genes meeting in beautiful Crete as the 94th Harden Conference hosted by @biochemsoc.bsky.social Register now - lots of opportunities for selected talks www.eventsforce.net/biochemsoc/f...
- Reposted by Lori PassmoreCan't wait for this meeting! Lots of exciting, macromolecular science lined up!
- Alessandro Costa @costalaboratory.bsky.social, Dana Branzei and myself are co-organising the 2026 Machines on Genes meeting in beautiful Crete as the 94th Harden Conference hosted by @biochemsoc.bsky.social Register now - lots of opportunities for selected talks www.eventsforce.net/biochemsoc/f...
- Alessandro Costa @costalaboratory.bsky.social, Dana Branzei and myself are co-organising the 2026 Machines on Genes meeting in beautiful Crete as the 94th Harden Conference hosted by @biochemsoc.bsky.social Register now - lots of opportunities for selected talks www.eventsforce.net/biochemsoc/f...
- Reposted by Lori Passmore🚨Attention prospective PhD students🚨 Are you interested in molecular mechanisms, RNA viruses, structural biology or biophysics? 🧬🦠🧪 We have THREE fully-funded PhD projects available for October 2026 entry: www.findaphd.com/phds/?Keywor... Please share/repost, and get in touch if you're interested
- This work is now officially published @natsmb.nature.com with some fun new analyses included in the revised version. Congratulations to all the authors! @connyyu.bsky.social @rappsilber.bsky.social @lrsinn.bsky.social @fjoreilly.bsky.social www.nature.com/articles/s41...
- New work from the lab! James Stowell led this project showing the importance of multivalency and phospho-regulation in mRNA decay. This has many parallels with other mechanisms in gene expression. biorxiv.org/cgi/content/...
- Reposted by Lori PassmoreJoin us on Monday 13th October at 11am for an #LMBSeminar from Bonnie Bassler on ‘Quorum sensing across domains: From viruses to bacteria to eukaryotes’ Visit our website for more info: www2.mrc-lmb.cam.ac.uk/news-and-eve...
- Reposted by Lori PassmoreTwo group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.
- Reposted by Lori PassmoreStart independent research at the JIC with us 👇. Really interested in finding those with an interest in structural biology and biochemistry of plants and microbes. Please do get in touch by email if you'd like to know more 👍
- VACANCY - Independent research fellowships leading to tenured positions We’re inviting applications from outstanding researchers who either hold, or wish to apply for, Independent Research Fellowships. APPLICATION DEADLINE: 10 November 2025 Click here to apply: jic.link/Fellows
- We have an open post-doc position in my group to study mRNA cleavage and polyadenylation using biochemical reconstitution and cryoEM. Please get in touch if you are interested in joining this amazing team! 🔬🧬🤩 #RNA #cryoEM
- We’re looking for a #postdoc to join Lori Passmore’s group, within a programme aimed at understanding addition of mRNA poly(A) tails More info: www.nature.com/naturecareer... Closes 06 OCT #ScienceJobs #PostdocJobs
- Just a reminder that August is peak school holidays in the UK, but also more broadly in Europe and in Canada. If you schedule conferences during August you exclude a large proportion of people from these regions who have family obligations.
- Reposted by Lori PassmoreThe Garnett Lab is excited to launch DepMap Miner, a new tool to explore cancer dependency data! Built on the Sanger DepMap, the DepMap Miner brings together multi-omic and functional datasets for over 1300 cancer cell models. Start mining data now: dataminer.depmap.sanger.ac.uk
- Reposted by Lori PassmoreWe are hiring-join us!
- 🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬 Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...
- Reposted by Lori PassmoreJust one more week left to get an application in! Starting my lab at the Perutz and the @viennabiocenter.bsky.social has been a fantastic opportunity that shaped me as a scientist!
- 📢 Open Call! The Max Perutz Labs invite applications for a Tenure-Track Professorship in Mechanistic Cell and Developmental Biology. More details ➡️ tinyurl.com/3fbkp89c
- Reposted by Lori PassmoreGreat start to the EMBL translation control meeting with a keynote from @lapassmore.bsky.social. Excited for all the science to come. #EMBLProtein
- Reposted by Lori PassmoreAre you a postdoc interested in the mechanisms of disease? Do you have a great record and an exciting vision? Come and start your own lab @dunnschool.bsky.social by applying for sponsorship for early career fellowships. Deadline 30th September...pass it on! www.path.ox.ac.uk/work-with-us...
- Unprompted, the 14yo told me she has a deep hatred for Comic Sans. I love that kid so much.
- Reposted by Lori PassmoreFantastic talk by Ethan showcasing our work with @lapassmore.bsky.social lab at @cshlmeetings.bsky.social #RNAPR25! Hurray Ethan!
- Reposted by Lori Passmore⏰Early Bird and Talk Submission Deadline closing soon - Tuesday 26th August 2025 📣Don’t miss your chance to be part of the amazing #DRRSC26 meeting. 👉 Click here for further details & registration: bit.ly/46YQZjW
- Congratulations to @bcarrick.bsky.social on his Shurl and Kay Curci Fellowship through the Life Sciences Research Foundation! Looking forward to the work to come!
- Incredibly honored to be a Shurl and Kay Curci Fellow of the Life Sciences Research Foundation. Thanks to Marv and Judith for their support during my PhD and @lapassmore.bsky.social for her backing and mentorship in my postdoc work. lsrf.org/current-fell...
- Reposted by Lori PassmoreExcited to share our latest work! We found transcription factor SPT6 and phosphorylated Pol II CTD help recruit U1 snRNP to elongating Pol II, allowing efficient co-transcriptional splicing. Glad to be featured in the Editors’ Highlights! www.nature.com/articles/s41... #splicing #cryoEM
- Reposted by Lori PassmoreProud to share our work where we resolved a longstanding question regarding the existence of a human telomerase dimer and provided insights into its function. Led by 3 amazing lab members in collaboration with @yiliangding.bsky.social and @rdaslab.bsky.social. www.science.org/doi/10.1126/...
- Reposted by Lori Passmore📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Molecular Mechanisms of Disease. More information ➡️ tinyurl.com/3yn883b8
- Reposted by Lori PassmoreCongratulations to LMB Group Leaders Leo James, Greg Jefferis & Marta Zlatic who have been elected Fellows of the @royalsociety.org! Congratulations also to the #LMBAlumni joining them: John Briggs, Graham Hatfull & Baljit Khakh. Read more: www2.mrc-lmb.cam.ac.uk/leo-james-gr... #LMBNews
- Reposted by Lori PassmoreCongratulations to the nine outstanding Cambridge scientists who have been elected as Fellows of the @royalsociety.org, the UK’s national academy of sciences and the oldest science academy in continuous existence. Explore their research 👉 www.cam.ac.uk/research/new... #CambridgeUniversity
- Reposted by Lori PassmoreCome and join us! We’re hiring a new Group Leader in Generative Biology at the @sangerinstitute.bsky.social Building AI models or the data to train them? Core funding of >$130M a year for a faculty of ~30. www.nature.com/naturecareer... acrobat.adobe.com/id/urn:aaid:... pls RT!
- New work from Matti Turtola showing that mRNA poly(A) tail length is controlled by a kinetic ruler. A real pleasure to work with him! www.biorxiv.org/content/10.1...
- New abstract deadline May 8, 2025. Should be a great meeting!!
- REGISTRATION CLOSING SOON! 🚨 #Nucleic25 is fast approaching! Don’t miss your chance to join the conference in sunny Portugal! Registration Deadline: 10th April 2025 David & Wei can’t wait to see you there! 👉 Click here for more information on how to secure your place: bit.ly/4ckluBE
- Canadians 🇨🇦 abroad - you can register to vote in the election! You need to do it soon. www.elections.ca/content2.asp...
- Reposted by Lori PassmoreNew Gordon Research Conference Alert: Synthetic Lethality Approaches in Oncology. www.grc.org/synthetic-le.... Join us 20-25th July 2025 for an intimate meeting with thought leaders in the field. Great for networking and opportunities for early career scientists to present their research.
- Reposted by Lori PassmoreJust a reminder that our tenure track group leader position in the Structural Studies Division of @mrclmb.bsky.social will close in four days! mrc.tal.net/vx/lang-en-G...
- Reposted by Lori PassmoreSAVE THE DATE! The next EMBO | EMBL Symposium on 'DNA replication and genome maintenance: from basic biology to disease' will be held October 20-23, 2026. Organized by Helle Ulrich (IMB), Johannes Walter (Harvard) and Anja Groth (Danish Cancer Institute). www.embl.org/about/info/c...
- Reposted by Lori PassmoreRNA xkcd.com/3056
- For all of you who cannot access pubmed, here is a good alternative: europepmc.org
- Thank you @ebi.embl.org !!
- Reposted by Lori PassmoreWe are looking for a senior administrator to take care of the Structural Studies Division at @mrclmb.bsky.social. Come and work for the benefit of human health in a fantastic environment. Happy to chat! www.jobs.ac.uk/job/DLY086/s...
- Reposted by Lori PassmoreBIG news: Jason Chin is leaving the Division of Protein & Nucleic Acid Chemistry of @mrclmb.bsky.social to spend yet another billionaire's ££ in Oxford. This will create a gap that will need filling! So, if you're thinking of making a move, now is the time to reach out! www.eit.org/news/profess...
- Reminder - still one month to apply to be a tenure track group leader at MRC LMB. Please do reach out for any information.
- Come and joint us at @mrclmb.bsky.social ! We have an opening for a new group leader in the Structural Studies Division. We are very interactive and collaborative with amazing facilities and generous core funding. Get in touch with myself or @sjorsscheres.bsky.social if you have any questions.
- Reposted by Lori PassmoreHere’s a gift link. This is a good one to share with your non-scientist friends and family www.nytimes.com/2025/02/14/o...
- Harold Varmus in the NYT: "Historically, Americans of all political persuasions have respected science and celebrated its breakthroughs (...) And yet, for baffling reasons, the executive branch is now waging war on America’s scientific enterprise." www.nytimes.com/2025/02/14/o...
- Come and joint us at @mrclmb.bsky.social ! We have an opening for a new group leader in the Structural Studies Division. We are very interactive and collaborative with amazing facilities and generous core funding. Get in touch with myself or @sjorsscheres.bsky.social if you have any questions.
- Join our Structural Studies Division, leading a research group developing computational methods to address questions in molecular & cellular biology! You will be supported by core funding, excellent facilities & enthusiastic colleagues. Apply by 18 MAR www.nature.com/naturecareer...
- Reposted by Lori PassmoreThe LMB Rising Talent Fellowship for Black heritage scientists is open for applicants! With this 3 year postdoc position we want to enable scientists of Black heritage to learn & grow their experience. To apply and for full details check here: www2.mrc-lmb.cam.ac.uk/recruitment/... Please share!
- Abstract deadline approaching for the Fusion Nucleic Acids meeting. Join us for a fun meeting! #RNA www.fusion-conferences.com/conference/1...
- Reposted by Lori PassmoreDo you love all kinds of imaging? Are you a traveler across scales? Do you dream of bringing structure and cell biology together? (Also, ⛷️🏔️anyone?) Join us for this incredible meeting full of state-of-the-art methods, killer bio applications and engaging speakers! (1/2)
- Mark your calendars! Jan. 16 (11:59pm MST) is your last chance to submit your abstract or scholarship application for a short talk alongside @thevillalab.bsky.social and others at Imaging Biomolecules Across Scales. Don't miss out—apply now: keysym.us/KSImaging25 #KSImaging25 #keystoneconferences
- Reminder that @arianebriegel.bsky.social compiled a nice list of women in #cryoEM . I often get asked to recommend people and this is a great place to start 😀 briegel-lab.org/women-in-cry...
- Reposted by Lori PassmoreMark your calendar: the next Egmond DNA repair meeting will take place in 2026 from April 19 - 24! You can pre-register to receive announcement here: forms.lumc.nl/lumc2/Egmond Registration will open by June 2025.
- Reposted by Lori PassmoreThe Neurobiology Division at the MRC LMB is looking for a new group leader: www.nature.com/naturecareer...
- Reposted by Lori Passmore🎉 We’re delighted to announce that the ICR's Dr Basil Greber (@bjgreber.bsky.social) has been selected for the EMBO Young Investigators Programme. Dr Greber, Group Leader in Structural Biology, is one of 27 life scientists in this year's cohort. 👏
- Reposted by Lori PassmoreWonderful to see that our colleague @marta-shahbazi.bsky.social is now an EMBO YIP. www.embo.org/press-releas...
- Very cool study!!👇👇
- I’m thrilled to share a collaborative story from @Mendell_lab and Jan Erzberger labs, led by postdoc extraordinaire Xiaoqiang Zhu. We showed that in addition to their canonical decoding function, tRNAs play a key role in regulating mRNA stability during translation! www.science.org/doi/10.1126/...
- Reposted by Lori PassmoreConsidering a PhD in molecular biology? There’s still time to apply to join the LMB in October 2024. Applications close on 3rd DEC. Visit our website for more info: www2.mrc-lmb.cam.ac.uk/students/int...
- Reposted by Lori PassmoreExciting highlights of the recent complex life of #RNA symposium @embl.org featuring Matt Disney, Juan Valcarcel, @lapassmore.bsky.social, Herve Le Hir, Andreas Meyer, Yiliang Ding, Seitz Herve, Maria Hondele, @juliusbrennecke.bsky.social, Bahareh Torkzaban www.embl.org/news/science...
- Reposted by Lori Passmorei might be biased, but this place is amazing: great colleagues, vibrant campus, brilliant students/postdocs - and Vienna! perfect for starting an ambitious project. apply now for a GL position at the IMP … www.imp.ac.at/career/open-...
- Reposted by Lori Passmore⚠️THREAD OF ALL SCIENCE-RELATED STARTER PACKS! ⚠️ 🔄Share to help people finding its topic/field - STRUCTURAL BIOLOGY Structural Biology 1: bsky.app/starter-pack... Structural Biology 2: bsky.app/starter-pack... Crystallography: bsky.app/starter-pack... Synchrotron&CryoEM: bsky.app/starter-pack...
- Reposted by Lori PassmoreI kind of forgot how to announce Feeds, but here goes For an all-in-one CryoEM Feed: #CryoEM, #CryoET, #TeamTomo all-in-one feed that curates posts from the last 7 days containing the various cryoEM and cryoET related hashtags and keywords. bsky.app/profile/did:...
- Here is a starter pack for CryoEM/ET enthousiasts To be completed go.bsky.app/JmQksCat://did:plc:pkzh2psjildyroejswbveobs/app.bsky.graph.starterpack/3lahqziu6gr2l
- Reposted by Lori PassmoreThere’s also a very nice adjacent structural biology pack. go.bsky.app/DDetSBpat://did:plc:ymfz6bh2paxlrkqugoveuug3/app.bsky.graph.starterpack/3l6xva7khb62x
- Reposted by Lori PassmoreWe have a fully-funded 4 year PhD position in the lab, for October 2025 entry. Both UK and international students are eligible to apply. Please share and get in touch if you're interested 🧬🧪🦠 www.findaphd.com/phds/project...
- Reposted by Lori Passmore🔬🧫 🧬 Are you looking for an opportunity to set up your own laboratory focused on RNA or cell biology in an inspiring environment surrounded by like-minded researchers? The IIMCB in Warsaw is offering an excellent opportunity www.rnasociety.org/junior-group... www.iimcb.gov.pl/en/ #CellBiology #RNA
- It is so great to see the community growing over here on Bluesky! Looking forward to engaging in more science discussion 🥳
- We have an open postdoc position to study the molecular mechanisms of DNA repair ! 🧬🔬 The project will build on recent findings from the lab nature.com/articles/s4158… and established collaborations, using cryoEM and single molecule imaging. With access to fantastic facilities at MRC LMB.
- Come join the amazing members of my team 🤩🤩!
- Apply here. Deadline 11 Nov. www.nature.com/naturecareer...
- Really helpful starter packs!
- Reposted by Lori PassmoreJoin us Oct 23 for the next Fragile Nucleosome Seminar, with Alan Jiao (Yang Shi's lab, Ludwig) and Matthew Swaffer (Wellcome Centre) speaking on H3K27M oncohistones and mRNA scaling with cell size!! Register here: us06web.zoom.us/webinar/regi... #AcademicSky🧪🧬#epigenetics #chromatin #EpiSci
- New work from the lab! James Stowell led this project showing the importance of multivalency and phospho-regulation in mRNA decay. This has many parallels with other mechanisms in gene expression. biorxiv.org/cgi/content/...
- Poly(A) tails control translation and stability of eukaryotic mRNAs. The Ccr4-Not deadenylation complex shortens these tails to control gene expression in a regulated and context-dependent manner. But how are specific mRNAs targeted for decay at the correct time?
- Many different ‘RNA adaptor’ proteins (RNA-binding proteins) tether specific transcripts directly to Ccr4-Not. Intrinsically-disordered regions (IDRs) in RNA adaptors interact with Ccr4-Not. This promotes deadenylation of bound transcripts.
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View full threadWe conclude that phosphorylation can result in a rheostat-like response on the multivalent interaction allowing ‘tuning’ of deadenylation activity. This is a common principle across multiple RNA adaptors (e.g. Pumilio proteins, TTP/ZFP36) with yeast and human deadenylation complexes.
- Bluesky now has over 10 million users, and I was #1,007,137!
- Reposted by Lori PassmoreDear Elle MacPherson You and I had the same kind of breast cancer, HER+ (tends to be aggressive). I embraced conventional treatment (chemo, mastectomy, biologics); you eschewed these. We’re both alive years later. Here’s evidence that others should NOT copy you. 🧪 academic.oup.com/jnci/article...
- Reposted by Lori Passmore👏🎊 Congratulations to Perutz group leader Irma Querques on being named a 2024 Vallee Scholar! The Vallee Foundation recognizes outstanding young researchers in the biomedical field and will support Irma's study on transposons 🤩💡 Read more ➡️ tinyurl.com/467e2kfz
- Reposted by Lori PassmoreHere's an exciting job for the right person. Chance to join the senior staff at EMBO. Based in Heidelberg at the EMBO headquarters, it's a great organisation and a great place to work. www.embl.org/jobs/positio...
- Cheaper microscope could bring protein mapping technique to the masses www.science.org/content/arti...
