Jure Majnik
PhD student in (developmental/comp)neuroscience. Cossart lab (INMED, Marseille). track2p.github.io
- Reposted by Jure MajnikThis is who runs this account
- Reposted by Jure MajnikA new community-driven lab handbook for reducing conflict and creating more positive and equitable work environments gets strong support from a survey of 200 researchers. buff.ly/K7CGFLV
- Reposted by Jure MajnikI am very happy (and a bit scared) to present to you what we have been working on over the last 4 years. This manuscript is exactly what I dreamt of when I started the lab and I could not be happier and prouder of the outcome!
- Evolutionary dynamics of temporal transcription factor series in the insect optic lobe biorxiv.org/content/10.64898/20…
- Reposted by Jure MajnikSequences are everywhere! In every brain region. And are written in stone. Invariant Activity Sequences Across the Mouse Brain. Out today, by Célian Bimbard, with @kenneth-harris.bsky.social. Based on data by Célian and by @intlbrainlab.bsky.social. www.biorxiv.org/content/10.6...
- Reposted by Jure Majnik“A process which led from the amoeba to man appeared to the philosophers to be obviously a progress - though whether the amoeba would agree with this opinion is not known" - Bertrand Russell, 1976. Time-lapse video of Vampyrella lateritia eating Spirogyra algae from Science Source/Oliver Skibbe. 🦠
- Reposted by Jure MajnikAnd here is the PDF of the 4th course @college-de-france.fr. You will find the justification and presentation of geometric representation of cell decisions, a parsimonious mathematical model for signalling and cell state transitions tinyurl.com/yc7u296j
- My first paper just got published last week! *Longitudinal tracking of neuronal activity from the same cells in the developing brain using Track2p* elifesciences.org/articles/107...
- Also with a beautifully written 'insight article' by Renata Batista-Brito and Geoffrey Terral: *Neuronal Activity: Keeping track of moving targets* elifesciences.org/articles/109...
- And for a TLDR/summary of the paper you can check the 'blusky'-print from the bioarxiv version of the paper: bsky.app/profile/jure...
- How does a neuron get its activity? 👀 Check out our latest preprint, where we tracked the activity of the same neurons throughout early postnatal development: www.biorxiv.org/content/10.1... see 🧵 (1/?)
- Thanks to all the co-authors, I had great fun working on this for the last couple of years :)
- Reposted by Jure MajnikIntravital observation of neuronal and immune cell dynamics in the developing mammalian brain: @cellpress.bsky.social www.cell.com/cell/fulltex...
- Reposted by Jure MajnikA paper from my PhD lab is on Science! This is a really cool new way to utilize EM connectome datasets. Congrats to the team! www.science.org/doi/10.1126/...
- Reposted by Jure MajnikHow do neural circuits generate the walking rhythm? Using connectome simulations, @sarahpugly.bsky.social found a minimal central pattern generator (CPG) that produces oscillations in leg motor neurons. Same circuit motif for each 🪰 leg. w @bingbrunton.bsky.social www.biorxiv.org/content/10.1...
- Reposted by Jure MajnikOur Method of the Year 2025 is...drumroll please...EM-based connectomics!! Our Editorial introduces our choice and highlights six Comments and other related content in this special issue. Please join us in celebrating EM-based connectomics! 🎉🧠🔬 www.nature.com/articles/s41...
- Reposted by Jure MajnikFlipbook of zebrafish embryogenesis. Taken from December 1996 issue of @dev-journal.bsky.social. Still images from movie by Rolf Karlstrom and Don Kane. Flipping credit to @amjeve.bsky.social. #ZebrafishZunday #ZebrafishFunFacts 🧪
- Reposted by Jure MajnikGreat to see this published: Fitting dynamical landscape models to single-cell data, creating interpretable maps of cell decision making & developmental logic Applied to neural tube patterning, we show how morphogen signals reshape landscapes and drive fate decisions www.pnas.org/doi/10.1073/...
- Reposted by Jure MajnikHappy to share the first paper from my journey at @psich.bsky.social towards X-ray connectomics, now out in @natmethods.nature.com: www.nature.com/articles/s41...
- Reposted by Jure MajnikOur new paper showcasing molecular connectomics with pan-expansion microscopy is out in @natbiotech.nature.com! www.nature.com/articles/s41... This wonderful collaboration with @bewersdorflab.bsky.social was led by Ons M'Saad (now founder/CEO of Panluminate) and @allisonphysics.bsky.social. (1/5)
- Reposted by Jure MajnikHi, I’m David Brückner @davidbrueckner.bsky.social. I’ll take you through how cells in a tissue can use information distributed by biochemical gradients to make decisions, and how we can measure such positional information. buff.ly/RFxVeHh
- Reposted by Jure MajnikOur work on training biophysical models with Jaxley is now out in @natmethods.nature.com. Led by @deismic.bsky.social, with @philipp.hertie.ai, @ppjgoncalves.bsky.social & @jakhmack.bsky.social et al. Paper: www.nature.com/articles/s41...
- Reposted by Jure MajnikFelix Zhou's u-Segment3D is out: www.nature.com/articles/s41... It leverages 2D cell segmentations from orthoviews to generate a ‘consensus’ 3D segmentation. It does a great job on segmenting densely packed samples, and we have used the algorithm in many applications.
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How can we organize current theoretical approaches for developmental biology - from information to dynamical systems & GRNs - into a common framework? We propose to think along Marr's 3 levels: computational problem, algorithm, implementation Check out our review: arxiv.org/abs/2510.24536 - Reposted by Jure Majnik[Not loaded yet]
- Reposted by Jure MajnikWe have written two reviews providing a practical guide and fundamentals of cell migration: (1) How to select an optimal cell migration assay, (2) How to analyze cell migration data. We also added a perspective on AI methods of analysis. Coming out soon in Nature Methods.
- Reposted by Jure MajnikNew issue of Nature - with NINE studies on #brain #development from the BRAIN Initiative Cell Atlas Network (BICAN) 🧠🧪🔬 An amazing set of resources for all scientists working on the brain! 🧠 Immersive feature: www.nature.com/immersive/d4... 🧠 Perspective: www.nature.com/articles/s41...
- Reposted by Jure MajnikDo flies feel pain? Spooky new preprint from our lab on the cells and circuits that mediate nociceptive behaviors in adult Drosophila, led by graduate student (and newly minted PhD!) @jonesjes.bsky.social. 🪰⚡👻🎃 www.biorxiv.org/content/10.1...
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- Reposted by Jure Majnik🧠🌟🐭 Excited to share some of my postdoc work on the evolution of dexterity! We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have: (1) more corticospinal neurons (CSNs) (2) better hand dexterity (3) more dexterous climbing, which is linked to CSN number🧵
- Evolutionary expansion of the corticospinal system is linked to dexterity in Peromyscus mice biorxiv.org/content/10.1101/202…
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- Very grateful for the opportunity to present at Bernstein 2025 + an amazing conference overall 😊 @bernsteinneuro.bsky.social For anyone interested in the data here is the link to Zenodo: zenodo.org/records/1709... And the (almost final version of) the paper: elifesciences.org/reviewed-pre...
- 🧠 #BernsteinConference 2025 — Day 4 Recap The final day featured 4 Invited Talks and 3 Contributed Talks, wrapping up an inspiring week of #CompNeuro discussions. Thanks to all speakers and participants — we can’t wait to see you again next year! #BernsteinNetwork
- Reposted by Jure MajnikLook at her go! #invertebrates 🌿
- Reposted by Jure MajnikExciting news for #drosophila #connectomics and #neuroscience enthusiasts: the Drosophila male central nervous system connectome is now live for exploration. Find out more at the landing page hosted by our Janelia FlyEM collaborators www.janelia.org/project-team....
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- Reposted by Jure Majnik🧵1/14 Preprint thread! Can we predict a cell’s fate based on its dynamics? 🔮 Our new study unveils a framework for watching development unfold in real-time, revealing how a cell's shape and movement encode info about its future fate. 🔬📄 Preprint: tinyurl.com/4shf8v4x
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- Reposted by Jure MajnikPreprint - Excited to present WHOLISTIC, which extends the concept of whole-brain functional imaging to the entire body. Pioneering work by incredibly talented Virginia Ruetten @vmsruetten.bsky.social, this platform reveals whole-organism cellular dynamics in vivo. www.biorxiv.org/content/10.1...
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- Reposted by Jure MajnikPublic access to the first fly connectome that spans the whole CNS - BANC!: codex.flywire.ai?dataset=banc Different from prior connectomes - it is brain + cord (think spinal cord) We use it to ‘embody’ the system and find it resembles ‘subsumption architecture’ doi.org/10.1101/2025...
- Reposted by Jure MajnikIntroducing five concepts from dynamical systems to decode developmental regulatory mechanisms, have a read! @perez-carrasco.bsky.social @roederlab.bsky.social @mpipz.bsky.social This effort started in a morphogenesis meeting @kitp-ucsb.bsky.social in 2023. journals.biologists.com/dev/article/...
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- Reposted by Jure MajnikCheck out our new review/perspective (w/ @juangallego.bsky.social & Devika Narain) on neural manifolds in the brain! It was a lot of fun to think through these ideas over the past couple of years, and I'm excited it's finally out in the world! 🔗: www.nature.com/articles/s41... 📄: rdcu.be/ex8hW
- Reposted by Jure MajnikWhen neurons change, but behavior doesn’t: Excitability changes driving representational drift New preprint of work with Christian Machens: www.biorxiv.org/content/10.1...
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- Reposted by Jure Majnik1 To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised! 🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...
- Reposted by Jure Majnik1/ Mapping synaptic connectivity between individual neurons is extremely laborious. We developed BRISC, a new method that makes it possible to map inputs onto 100s of neurons in the same animal in a matter of weeks! Led by Alex Becalick and @antblot.bsky.social. 🧵 www.biorxiv.org/content/10.1...
- Reposted by Jure MajnikNo new genes needed to fly - just rewire what you have! 🦇🧬 Great new paper from the labs of @fany-real.bsky.social @stemundi.bsky.social @dariloops.bsky.social doi.org/10.1038/s415... #EvoDevo #SingleCell #BatWings
- How did the bat get its wings? New research from a collaboration between the labs of Stefan Mundlos (MPIMG), Dario G. Lupiáñez, and Francisca M. Real (@cabd-upo-csic.bsky.social) show how genetic programs were reused during the evolution of mammalian flight. --> www.molgen.mpg.de/news-2025-fl...
- Reposted by Jure MajnikThis isn't a coincidence, IMO. The fly community is generally super rigorous - because there are so many tools and techniques available, people expect you to really nail things in order to get published (and keep getting funded)
- Model organism communities are fantastic. Good work, "Drosophilists"! www.nature.com/articles/d41...
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