Jure Majnik
PhD student in (developmental/comp)neuroscience. Cossart lab (INMED, Marseille). track2p.github.io
- What's the theory/modeling version of "Naturalistic Neuroscience"?
- IMO: NeuroAI approaches + models with rich stimuli/behavior, interactive environments, and ethnologically relevant tasks. But I'm curious to hear thoughts folks have about this... I'm sure there's a variety of interesting ones
- I helped with this project during an MSc internship: arxiv.org/abs/2402.05266, I guess that might be an idea along those lines? Of course it depends a bit what one considers as being 'rich' in terms of stim/behaviour :)
- My first paper just got published last week! *Longitudinal tracking of neuronal activity from the same cells in the developing brain using Track2p* elifesciences.org/articles/107...
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View full threadAnd for a TLDR/summary of the paper you can check the 'blusky'-print from the bioarxiv version of the paper: bsky.app/profile/jure...
- How does a neuron get its activity? 👀 Check out our latest preprint, where we tracked the activity of the same neurons throughout early postnatal development: www.biorxiv.org/content/10.1... see 🧵 (1/?)
- Thanks to all the co-authors, I had great fun working on this for the last couple of years :)
- Also with a beautifully written 'insight article' by Renata Batista-Brito and Geoffrey Terral: *Neuronal Activity: Keeping track of moving targets* elifesciences.org/articles/109...
- Very grateful for the opportunity to present at Bernstein 2025 + an amazing conference overall 😊 @bernsteinneuro.bsky.social For anyone interested in the data here is the link to Zenodo: zenodo.org/records/1709... And the (almost final version of) the paper: elifesciences.org/reviewed-pre...
- 🧠 #BernsteinConference 2025 — Day 4 Recap The final day featured 4 Invited Talks and 3 Contributed Talks, wrapping up an inspiring week of #CompNeuro discussions. Thanks to all speakers and participants — we can’t wait to see you again next year! #BernsteinNetwork
- Our preprint on tracking cells in 2p calcium imaging during development is now online at @elife.bsky.social ! Its cool that the reviews are open - now its revision time 🫡🫡🫡 doi.org/10.7554/eLif...
- How does a neuron get its activity? 👀 Check out our latest preprint, where we tracked the activity of the same neurons throughout early postnatal development: www.biorxiv.org/content/10.1... see 🧵 (1/?)
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- This looks very cool, thanks for sharing! I might give it a try for the next series of experiments, it could help with starting imaging at an earlier age (as you show) or to be less invasive if we keep imaging for longer!
- Besides what we have shown, we think that tracking activity across days in development should allow all new sorts of experiments - for example tracking and perturbing developmental trajectories of individual cells 🔀 or testing theories about plasticity/activity dependent development ⚡
- Thanks to everyone involved! And for more info check the preprint: www.biorxiv.org/content/10.1...
- After making sure tracking was accurate, we quantified some basic activity statistics of the tracked neurons, showing an increase in rate, decrease in pairwise correlations, loss of spatial structure and a decrease in dimensionality of spontaneous activity.
- Finally, by looking at the stability of neural activity across days, we describe a major developmental transition that coincides with the emergence of arousal state modulation.
- We developed and evaluated a new cell tracking algorithm called Track2p, that allowed us to overcome these issues and track hundreds of neurons per mouse during the second postnatal week of neocortical development. During this time the weight and (estimated) brain volume increased by almost 50% 😱
- If you are planning to track cells in calcium imaging recordings (not only in development) check it out here: github.com/juremaj/trac... - It’s all open source with a user-friendly GUI.
- Tracking activity from the same cells across days has been possible in the adult brain for a while now, but during development this becomes difficult due to brain growth and other developmental changes.
