Fabrizio Musacchio
Physicist by training, working in computational neuroscience at the @dzne.science. Interested in how neural dynamics and learning shape brain function and behavior, using modeling and data analysis.
🌍fabriziomusacchio.com
🐘mastodon.social/@FabMusacchio
- Reposted by Fabrizio Musacchio[Not loaded yet]
- Reposted by Fabrizio MusacchioThe brain is more than spiking neurons. Astrocytes, a large fraction of cells, propagate electrical influences without spiking. And cortical neurons spike only intermittently. Electrical signals are continuous and across all cells. #neuroscience www.quantamagazine.org/once-thought...
- Reposted by Fabrizio MusacchioWhy don’t neural networks learn all at once, but instead progress from simple to complex solutions? And what does “simple” even mean across different neural network architectures? Sharing our new paper @iclr_conf led by Yedi Zhang with Peter Latham arxiv.org/abs/2512.20607
- Reposted by Fabrizio MusacchioToday I'd like to honor the memory of my mentor and friend, Roger Tsien, born 1952 February 1. Today would have been Roger's 74th birthday. Most know Roger for his 2008 Chemistry Nobel Prize with Shimomura and Chalfie. Roger made GFP into the versatile imaging method it is now.
- Reposted by Fabrizio Musacchio[Not loaded yet]
- Reposted by Fabrizio Musacchio[Not loaded yet]
- Reposted by Fabrizio MusacchioThis poses an intriguing question: how is cytoplasm robustly and accurately organized in absence of physical barriers, and how is cytoplasmic partitioning achieved within the constrained time window of rapid embryonic divisions? (2/9)
- Reposted by Fabrizio MusacchioReally excited to share our new paper in @nature.com! We uncovered how a physical instability of the cytoplasm coupled with the cell cycle drives cytoplasmic partitioning in early embryos #zebrafish #drosophila. Read more in this🧵 www.nature.com/articles/s41... 🤩 @poldresden.bsky.social @mpi-cbg.de
- Reposted by Fabrizio Musacchio[Not loaded yet]
- Reposted by Fabrizio MusacchioLatest work from the lab by Aude Nommick et al., in which we propose a "size-scaling" model for microtubule force exertion that regulates centrosome centration vs decentration during embryo development! @ijmonod.bsky.social www.biorxiv.org/content/10.6...
- #ArXiv is cracking down on #AI #slop and will only allow initial submissions based on recommendations from established ArXiv authors. 🌍 science.org/content/article/arx… #preprint #AIslop
- Reposted by Fabrizio MusacchioWhat's the relation between voltage and calcium in dendrites? Xiang Wu studied this in CA2 hippocampal pyramidal cells in behaving mice. www.biorxiv.org/content/10.6...
- I studied at the #UniversityOfCologne and Susanne Crewell was one of my professors. Nice to see my #AlmaMater highlighting her work on such a relevant #climate topic! #unicologne #cologne #climatechange #meteorology
- ✈️ 🌡️ How do contrails affect the climate? 🤔 Professor Dr. Susanne Crewell from the Institute of Geophysics and Meteorology at the University of Cologne gives us the answer in the new issue of the #unimagazin ▶️ uni.koeln/KEV9B #uniköln #unicologne #unimagazin
- Reposted by Fabrizio MusacchioExcited to share our new preprint! We explore the link between the locus coeruleus (LC) and arousal for astrocytes, pyramidal cells, interneurons in the hippocampus. A fantastic collaboration with @sianduss.bsky.social @bohaceklab.bsky.social, and many others: www.biorxiv.org/content/10.6... 1/5
- Reposted by Fabrizio Musacchio[Not loaded yet]
- Reposted by Fabrizio MusacchioTalk on "High-dimensional neuronal activity from low-dimensional latent dynamics" at NeurIPS 2025 with @haydari.bsky.social now accessible online 🎥: neurips.cc/virtual/2025... Please reach out if you have any comments or ideas for follow-up work!
- Reposted by Fabrizio Musacchio[Not loaded yet]
- Reposted by Fabrizio Musacchio[Not loaded yet]
- I didn't even realize how long I had been waiting for a tool like this!
- Want to get the data out of a PDF figure? As in, the actual data – not a rough trace-along-the-lines version? I made an app you might like: adamkucharski.github.io/pdf2plot/ It all started a few years ago... 🧵
- Reposted by Fabrizio MusacchioSeveral #CompNeuro PhD positions open at the University of Göttingen! 👇
- 📢Applications are open for the second cohort of our RTG! Learn more about the opportunities: www.uni-goettingen.de/de/open+posi... 🔔Join our info meeting on Dec 10, 1 p.m. CET. Register via: survey.academiccloud.de/index.php/34...
- Striking how clearly sudden qualitative change is already formalized here. Anticipating much of what later became #TippingPoint theory. #CatastropheTheory #DynamicalSystems #Topology #ComplexSystems
- Is there a mathematics of discontinuous behavior? Christopher Zeeman was a leading proponent of Catastrophe Theory, a topological approach to sudden change that underpins much of today’s work on tipping points. This is his beautiful 1976 paper in @sciam.bsky.social www.jstor.org/stable/pdf/2...
- Reposted by Fabrizio MusacchioIf you'd like to study Computational Neuroscience in Berlin, don't miss this info event on Wednesday! 👉 bit.ly/4aX4Yc8 #CompNeuro #BernsteinNetwork
- Reposted by Fabrizio MusacchioIn the next #BrAInWorldsJournalClub, Jerome Beetz will present the work of @shakedpa.bsky.social et al., in Science390,eadw6202(2025). DOI: 10.1126/science.adw6202 🦇Join @ilka-diester.bsky.social for an inspiring discussion! 💡
- Reposted by Fabrizio Musacchio📢The first UniReps x @ellis.eu speaker series in 2026 is coming! Come join us on 15th January at 1 pm CET with @noagarciad.bsky.social and @thwiedemer.bsky.social !
- Interesting read on how chunking can emerge directly from #synaptic dynamics: by temporarily suppressing groups of items via synaptic augmentation, #WorkingMemory can retrieve up to 8 items despite a base capacity of only 4.
- Reposted by Fabrizio Musacchio[Not loaded yet]
- Reposted by Fabrizio Musacchio🚨This was not supposed to be a Friday news dump. Come join us at the pre-COSYNE hackathon! And if can’t make it to the hackathon, don’t overthink it. Start working on the full CON2PHYS project: mchini.github.io/con2phys/ Remember that submissions will be eligible for co-authorship!
- I can’t help but think that the morphodynamic patterns in this video strongly remind me of an #MHD #plasma simulation: continuous flows, deformations along implicit fields, and structures that arise from dynamics rather than static forms. … However, I am biased. #SpacePhysics #Magnetohydrodynamics
- Open-source atlas of fruit fly development DynamicAtlas is a high-res framework for morphological studies 📹 M. F. Lefebvre, V. Jain-Sharma, N. Claussen & N. P. Mitchell et al @streichan.bsky.social lab University of California Santa Barbara in @natmethods.nature.com ➡️ bpod.org.uk/archive/2026...
- Reposted by Fabrizio MusacchioPlease spread the word🔊My lab is looking to hire two international postdocs. If you want to do comp neuro, combine machine learning and awesome math to understand neural circuit activity, then come work with us! Bonn is such a cool place for neuroscience now, you don't want to miss out.
- Reposted by Fabrizio MusacchioExcited to be giving the van Vreeswijk Theoretical Neuroscience Seminar this Wednesday, Jan 14, where I'll talk about "Computation Through Neuronal-Synaptic Dynamics"! www.wwtns.online
- Reposted by Fabrizio Musacchio[Not loaded yet]
- Reposted by Fabrizio MusacchioWhy does life explore so few of the forms it could possibly take? Using fractal descriptors, this #scienceadvances paper shows that Earth’s biosphere clusters around simple shapes, reflecting deep evolutionary constraints. @artemyte.bsky.social @manlius.bsky.social www.science.org/doi/pdf/10.1...
- Reposted by Fabrizio Musacchio[Not loaded yet]
- Reposted by Fabrizio Musacchio[Not loaded yet]
- Reposted by Fabrizio MusacchioWanna compare dynamics across neural data, RNNs, or dynamical systems? We got a fast and furious method🏎️ The 1st preprint of my PhD 🥳 fast dynamical similarity analysis (fastDSA): 📜: arxiv.org/abs/2511.22828 💻: github.com/CMC-lab/fast... I’ll be @cosynemeeting.bsky.social - happy to chat 😉
- Reposted by Fabrizio Musacchio🎓 Are you just beginning your journey into #CompNeuro? Explore our guide to degree programs in Germany for a comprehensive start 👇 bernstein-network.de/en/teaching-...
- Cool to see a concrete alternative to #ReLU #backprop models that remains both interpretable and biologically grounded: Qin et al. introduce #ReSU, Rectified Spectral Units, as a replacement for ReLU. 📄 arxiv.org/abs/2512.23146 #CompNeuro #NeuroAI #neuroscience 🧪
- Reposted by Fabrizio MusacchioKind of flew under the radar, BUT we released napari-omero 0.6 recently 🥳 @openmicroscopy.org You can now down-/upload ROIs from and to OMERO inside @napari.org 🤩Bringing the power of napari for annotation to the management of OMERO :) Thanks @psobolewskiphd.bsky.social and other maintainers!
- Reposted by Fabrizio Musacchio[Not loaded yet]
- Reposted by Fabrizio Musacchio[Not loaded yet]
- Reposted by Fabrizio MusacchioAnnouncing eurosky.social accounts - launching January 2026. ✅ Managed by Eurosky, a European non-profit initiative ✅ Hosted on European cloud ✅ Governed by European law www.eurosky.social/register
- Reposted by Fabrizio Musacchio[Not loaded yet]
- Reposted by Fabrizio Musacchio[Not loaded yet]
- Reposted by Fabrizio MusacchioCheck out our new work on motor learning across multiple brain regions!
- 🧠 New year, new preprint! Why does motor learning involve multiple brain regions? We propose that the cortico-cerebellar system learns a "map" of actions where similar movements are nearby, while basal ganglia do RL in this simplified space. www.biorxiv.org/content/10.6...
- Reposted by Fabrizio Musacchio🚨 New preprint! Why do some insights from spikes translate to field potentials while others don't? In this paper we compare visual memory representations in spikes and LFPs to propose a general framework that answers this question. www.biorxiv.org/content/10.6... 🧵 (1/10) 🧠🟦 🧠💻
- Reposted by Fabrizio Musacchio[Not loaded yet]
- Reposted by Fabrizio Musacchio
How can cells use information from neighboring cells to improve the spatial precision of morphogen patterns? 🤔 We show that cells can gain positional information by "talking" to their neighbors - how much depends critically on spatial correlations of the patterns. buff.ly/w56OUJT - Reposted by Fabrizio MusacchioHere's another, showing raw voltage throughout the dendritic tree, the virtual reality location of the animal, the mouse-eye view, and the voltage at the neuron's soma.
- Reposted by Fabrizio MusacchioWhat is the computational role of dendritic excitations? Byung Hun Lee and team mapped voltage dynamics throughout the dendritic trees of CA1 pyramidal neurons in mice navigating in virtual reality. www.biorxiv.org/content/10.6...
- Reposted by Fabrizio MusacchioHappy new year! My all sky camera imaged the sky every 15 seconds and this picture shows what happened in the sky in 2025. It shows the length of the night and day with the hourglass shape, the monthly lunar cycle with the diagonal bands, the elevation of the Sun at local noon, and lots of clouds.
- Reposted by Fabrizio MusacchioNYE fireworks < neurons expressing iGluSnFR3! Developed at our Janelia Research Campus, iGluSnFR3 is a fluorescent sensor designed to rapidly detect & image glutamate — our brains' main chemical messenger — allowing researchers to observe (dazzling) neural communication as it happens. 🎆
- Reposted by Fabrizio Musacchio[Not loaded yet]
- Reposted by Fabrizio Musacchio[Not loaded yet]
- Reposted by Fabrizio MusacchioA must-read review. It argues that brain areas are only one of several organizing principles and are not especially central, given their weak correspondence to function. Cytoarchitecture and connectivity are a starting point, not the endpoint. www.nature.com/articles/s41... #neuroscience
- Reposted by Fabrizio MusacchioWhat if the human brain computes quantum-like, without being quantum? New work by @melisupf.bsky.social Gus Deco shows that whole-brain models with quantum-like (QL) probability rules best match human brain data. @manlius.bsky.social @icreacommunity.bsky.social www.biorxiv.org/content/10.1...
- Reposted by Fabrizio Musacchio[Not loaded yet]
- Reposted by Fabrizio MusacchioI don't always get pretty, isolated, AND transfected primary neurons in culture, but when I do I take advantage.... Rat hippocampal neuron overexpressing ThymosinB4-mScarlet and imaged for 16hr on a @zeiss-microscopy.bsky.social LSM880 with Airyscan. #FluorescenceFriday #Microscopy
