adamezracohen
- What's the relation between voltage and calcium in dendrites? Xiang Wu studied this in CA2 hippocampal pyramidal cells in behaving mice. www.biorxiv.org/content/10.6...
- Xiang built a fancy microscope which combines spinning disk confocal and dual-wavelength micromirror-patterned structured illumination (we put a hole in the side of our spinning disk!). He co-expressed Voltron2 and jGCaMP8m, and imaged in two colors through a custom prism implant.
- Come to my talks!
- Reposted by adamezracohenGreat news! @mariaingaramo.bsky.social 's company (Nonfiction Labs) made a remote-controlled antibody. Its binding turns on and off with a magnet. This is a HUGE step towards our dream of magnetically controlled drugs. Imagine a cancer drug that ONLY attacks the tumor, not the rest of your body.
- We went into this expecting we might see each branch doing its own electrical dance; but the voltage is really stiff. Electrical length constants are long, so voltage is a poor variable for compartmentalizing sub-cellular information.
- What is the computational role of dendritic excitations? Byung Hun Lee and team mapped voltage dynamics throughout the dendritic trees of CA1 pyramidal neurons in mice navigating in virtual reality. www.biorxiv.org/content/10.6...
- I just learned that @bhlee1117.bsky.social has an account here. Nice work, Byung Hun!
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- When a larval zebrafish twitches its tail, the vascular endothelium lights up with a calcium signal, mediated by Piezo1. We used to think mechanosensing in endothelial cells was about sensing blood flow, but at least in this case it's about sensing body motion.
- Work brought across the finish line by Bill Jia, started in my lab more than a decade ago by Xin Tang. More here: www.sciencedirect.com/science/arti...
- History of modern art: abstracts expressionism and cerealism.
- Reposted by adamezracohenExcited to share the latest from the lab on the molecular mechanisms of silencing and un-silencing a hippocampal engram ensemble. Was fun using a variant of the EPSILON technique developed by Adam Cohen's lab. (1/2) www.sciencedirect.com/science/arti...
- In small enclosed structures (like vesicles), the flickering of individual ion channels can have substantial effects on membrane voltage and internal ion concentrations. Mean-field conductance-based models break down. We studied what happens: www.biorxiv.org/content/10.1...
- Reposted by adamezracohenNemo needs gap junctions, too. New preprint with Marleen Klann, Vincent Laudet, et al. showing anemonefish Snowflake mutant due to E42K substitution in Connexin Gja5b. Found exact same E42K in zebrafish gja5b (= leopard) by ENU, to the nucleotide! Details, inferences: www.biorxiv.org/content/10.1...
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- "The axon does not think. It only ax." George Bishop, 1965 😂
- I like this 😀.
- Astrocytes connect specific brain regions through plastic gap junctional networks biorxiv.org/content/10.1101/202…
- Jurassic parking.
- A rare appearance of my Dad on the internet!
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- I wrote about the government's attacks on Harvard. Hope this reaches a few persuadable minds. prosyn.org/PhWi74r?h=Ky...
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- Now out in JACS. pubs.acs.org/doi/full/10.... Grateful to thoughtful reviewers who found some errors in our model and encouraged us to make a better one! A renaissance in magnetobiology is coming...
- This guy deserves a Nobel Prize, an IgNobel Prize, and a Darwin Award (honorable mention, for effort). www.nprillinois.org/2025-05-02/h...
