Meghna Gupta
Assistant Professor at Oregon Health & Science University (OHSU) | Structural Biology | Membrane proteins | Organelle structure and function | Fatty-acid metabolism | https://www.mguptalab.com | #NewPI
- Reposted by Meghna GuptaI’m so excited to share that I’ve accepted an assistant professor position at the University of Colorado Anschutz, BMG department and Barbara Davis Diabetes center! I’m so grateful to many who have helped me get here, especially mentors at Joslin, @hmsbpa.bsky.social @leadingedgeprogram.bsky.social
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- Exciting holiday present for the Gupta lab! 🎉 🎊 Our paper "Molecular mechanism of substrate transport by human peroxisomal ABCD3" is now published in @pnas.org !! 🎉 🎊 lnkd.in/gPaFdEMn. @ohsunews.bsky.social #OHSU #mguptalab #NIHfunded www.mguptalab.com
- Great start to #CellBio2025 in Philadelphia with "The Peroxisome Renaissance: From Molecular Mechanisms to Cellular Functions" session organized by @fredmast.bsky.social. Really enjoyed speaking alongside Bonnie Bartel, Michael Skowyra, Jie Sun, Francesca Di Cara, PhD, and Peter Kim. 🙌
- Reposted by Meghna GuptaNew preprint out! We show that PROTAC-induced ubiquitination can bypass canonical ERAD to degrade ER membrane proteins. Wonderful collaboration w/ @dannomura.bsky.social and huge credit to grad student superstar Sydney Tomlinson! www.biorxiv.org/content/10.1...
- Reposted by Meghna GuptaCryoET of microbes inside an animal organ? Yes it’s possible! Check out our new preprint showing how we did it! What an amazing collaboration with amazing scientists who made this possible!
- Nanoscale imaging of native symbiotic animal tissue using amultimodal large volume imaging pipeline for cryo-electrontomography biorxiv.org/content/10.1101/202…
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- Reposted by Meghna GuptaExcited to share the peer-reviewed version of our work, now online in @embojournal.org! Big thanks to our reviewers and @hvodermaier.bsky.social for facilitating this process. Looking forward to continuing this fun collaboration with @michaelnadbio.bsky.social! www.embopress.org/doi/full/10....
- Sharing the next installment of our fun collaboration with @michaelnadbio.bsky.social at the interface of #ubiquitin and #ADP-ribosylation! Building upon our identification of cellular MARUbylation, we now identify reader/writer E3 ligases that extend K11 polyUb! 🧵 www.biorxiv.org/content/10.1...
- Reposted by Meghna GuptaThe Leading Edge Fellows gathered this week to celebrate Zara Weinberg, a beloved member of our community. Our 7th cohort of Leading Edge Fellows (2026) will be named in her honor. The Zara Weinberg Leading Edge Cohort application is now open! Due Feb 2. www.leadingedgesymposium.org/apply/
- Reposted by Meghna GuptaZara Weinberg passed away earlier this week. She joined my lab earlier this year when her postdoc lab formally closed. She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.
- Reposted by Meghna GuptaZara Weinberg was a brilliant light both in and out of science. She changed the lives of everyone she interacted and loved for the better. Her legacy will live on through all of us and we will fight for a better world on behalf of her memory.
- Reposted by Meghna GuptaCheck out our new publication, a collaboration with Giovanni Luchetti and Vishva Dixit @ Genentech. We show that the E.coli effector NleL inhibits intestinal epithelial cell extrusion after #inflammasome activation via degrading the kinases ROCK1 and 2!! www.nature.com/articles/s41... Explainer 1/8
- Reposted by Meghna GuptaNow out in Science! Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle. In @vcushing.bsky.social's magnum opus, we use #cryoEM to figure out how the CDK-activating kinase recognises CDKs to fully activate them - a key step in cell cycle control. www.science.org/doi/10.1126/...
- Reposted by Meghna GuptaNominations for the June Almeida award for Mid/Senior-Career Women in Cryo-EM are now open! Submit your nomination via this link www.biophysics.org/awards-fundi... by November 14th to recognize an exceptional woman in our community.
- Events celebrating women in electron microscopy are rare, which made my recent experience at the Ernst Ruska-Centre (ER-C), Forschungszentrum Jülich, Germany, truly special. I had the privilege of not only attending but also serving as a young keynote speaker at this inspiring gathering. 🎉
- Reposted by Meghna GuptaLab’s 1st preprint! Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate. @cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation. He is on the job market!
- I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉 @karalmckinley.bsky.social We built the first transgenic model of menstruation in mice. We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪 www.biorxiv.org/content/10.1... 🧵
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- Reposted by Meghna GuptaI'm excited to share that I've started my lab @stanford.edu in the Neurobiology Department! neurobiology.stanford.edu/who-we-are/f... #stanford #newPI #neuroscience
- Reposted by Meghna GuptaOut today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism. www.nature.com/articles/s41...
- Reposted by Meghna GuptaHappy to share a new preprint from the Clarke & Vallese (@fravallese.bsky.social) labs reporting #cryoem structures of two RBC stomatin complexes – with AQP1 & UT-B - continuing the SPFH theme from our recent vault preprint! This was a fun one and has been cooking for a while - read on for more! ⬇️
- Thrilled to be heading to Spain next week to speak at the EMBO Workshop on Peroxisomes! 🧫🔬👩🔬 Looking forward to sharing our latest research and learning from incredible scientists working on these fascinating organelles. #peroxisomes #EMBOmeeting #cellbiology meetings.embo.org/event/25-per...
- Reposted by Meghna GuptaFirst pre-print from the Lucas Lab led by Matthew Giammar and @joshdcryoem.bsky.social online today! We develop a new, extensible Python implementation of 2DTM and apply it to build pixel size optimization, constrained search and characterize molecular motions in situ www.biorxiv.org/content/10.1...
- Reposted by Meghna GuptaExcited to announce the opening of the @fitzsimmonslab.bsky.social at @michiganstateu.bsky.social dept. of biochemistry & molecular biology! (1/3)
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- Reposted by Meghna GuptaWe have a preprint for you EHD2 forms rings on caveolae necks, in contrast to most EHDs forming helices. We determined its structure on membranes and show that N-term acts as a spacer By Elena, Vasya @vasiliimikirtumov.bsky.social, Jeff &Oli Daumke www.biorxiv.org/content/10.1...
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- Reposted by Meghna GuptaNew preprint in the lab combining what we like best: insects, love, chemistry and the olfactory system! 1/8 www.biorxiv.org/content/10.1...
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- Reposted by Meghna GuptaWe are thrilled to announce the 2025 Leading Edge Fellows! 40 outstanding postdoctoral fellows doing pioneering research in a wide range of biological and biomedical disciplines. Learn more about these exceptional scientists: www.leadingedgesymposium.org/fellows
- Our latest preprint on peroxisomal fatty-acid transport is live!! @ohsunews.bsky.social #OHSU @uofcalifornia.bsky.social #UCSF
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- Reposted by Meghna GuptaPurkinje cells form inhibitory connections on cerebellar nuclei cells. So, when Purkinje cells fire abnormally, as in disease states, we should see the inverse in nuclei cells, right? Well - it may not be so straightforward: tinyurl.com/PCtoNC @fralinbiomed.bsky.social @vtneuroscience.bsky.social
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- Reposted by Meghna GuptaSharing the next installment of our fun collaboration with @michaelnadbio.bsky.social at the interface of #ubiquitin and #ADP-ribosylation! Building upon our identification of cellular MARUbylation, we now identify reader/writer E3 ligases that extend K11 polyUb! 🧵 www.biorxiv.org/content/10.1...
- Reposted by Meghna GuptaExcited to share our new @science.org paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals. www.science.org/doi/10.1126/...
- Reposted by Meghna GuptaI'm excited to share our lab's newest publication on the structure and pharmacology of human GABA transporter 3 @natcomms.nature.com. Much to our surprise, GAT3 adopts an inward-open conformation in complex with the (moderately) selective antagonist SNAP-5114. 💊 🧪 #CryoEM #OpenAccess rdcu.be/ei2KY
- Reposted by Meghna GuptaExciting news!! I’m joining the tenure-track faculty at University of Colorado Boulder this fall as an Assistant Professor of Psychology & Neuroscience! The Sosa Lab will study how memory is shaped by cognitive and physiological demands, including during pregnancy and the postpartum period. 🧵
- Reposted by Meghna GuptaDear al, check out our latest paper with @uhammes.bsky.social . A great collaborative effort by Lukas and Lam!!
- Finally out… „Transport of phenoxyacetic acid herbicides by PIN-FORMED auxin transporters“ www.nature.com/articles/s41.... A collaboration between my group and @bjornppedersen.bsky.social led by the magic duo @lukas-schulz.bsky.social and @unglam.bsky.social
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- A step forward towards understanding mechanism of action of potential therapeutics for tackling Mycobacterium tuberculosis. Happy to have co-led this work with @nkhandelwal.bsky.social 🎊🎉
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