Jonathan Pruneda
Associate Professor at Oregon Health & Science University studying microbial interference in host ubiquitin signaling. Current ASM Northwest Branch President. Formerly @UWBiochemistry and @MRC_LMB.
- Reposted by Jonathan PrunedaIt is with deep sadness that we share that Michael J. Matunis, a professor in the Department of Biochemistry and Molecular Biology, has passed away. (1/4)
- Reposted by Jonathan PrunedaI've been working on Surface Morphometrics for a new version (coming soon), and made some significant (AI-assisted) performance improvements, especially in pycurv (20-50x!). If you've had technical issues or just felt like it was too slow, give it another try! #teamtomo github.com/GrotjahnLab/...
- The abstract deadline has been extended to February 15th! Don’t miss out!
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- Reposted by Jonathan PrunedaMy department at Washington State University is recruiting an Assistant or Associate Professor in vector-borne disease 🕷️🦟🦠 Full job description is linked below. Come join us on the Palouse!
- Reposted by Jonathan Pruneda💡 Ciliary homeostasis turns out to depend on an unexpected tug-of-war between UFMylation and ubiquitination. In a recent editorial in Cell Death & Differentiation, @jnpruneda.bsky.social and I highlight new work from Wang et al. 🧵👇
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- Reposted by Jonathan PrunedaApplications are open for PREP Bio at the University of Oregon! A great opportunity for postbacs looking for additional research experience while preparing for graduate school. More here: cas.uoregon.edu/UO-PREP-Bio
- Reposted by Jonathan PrunedaFriends, please help spread the word about our microbiology REU program at Montana State University. www.montana.edu/mbi/reu/ Each student receives a stipend ($7000 for 10 wks). Travel compensation, room, and board are also provided. Details in the attached pic--Feb 14 deadline 🧫🧪🦠#microsky
- Join us in Leiden for this exciting meeting on Pathogen Immunity and Signalling. The February 1st abstract submission deadline is fast approaching! Please help spread the news!
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- Reposted by Jonathan PrunedaWe are looking for a new RA to join our team working on host-pathogen interactions during Salmonella infection. The appointment is for two years and you will join a diverse team, using cell and protein biochemistry to further our understanding of pathogenesis. my.corehr.com/pls/uoxrecru...
- Reposted by Jonathan PrunedaExcited to announce the upcoming 2026 Microbial Toxins and Pathogenicity GRC and GRS meeting taking place July 12 - 17, 2026 at Waterville Valley in New Hampshire. This meeting will be chaired by yours truly and co-chaired by @sunnyshinlab.bsky.social www.grc.org/microbial-to...
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- Reposted by Jonathan PrunedaHello world! I am excited to announce my lab is open at the University of Utah in the Department of Biochemistry. We are looking for scientists at all levels interested in studying host-virus interactions in both bacteria and animals. Come join us in beautiful Utah! (photo is 10 steps from lab)
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- Reposted by Jonathan PrunedaI’m stoked to share my postdoc work with @sunnyshinlab.bsky.social, a collaborative effort with @metabailism.bsky.social & Brian Goldspiel, aided by many valued collaborators: Environmental Amino Acid Sensing Regulates the Rate of ASC Translation and NLRP3 Inflammasome Assembly. Some big takeaways:
- Environmental Amino Acid Sensing Regulates the Rate of ASC Translation and NLRP3 Inflammasome Assembly biorxiv.org/content/10.64898/20…
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- Reposted by Jonathan PrunedaI’m thrilled to share our work on phage triggers of the bacterial immune system in its final form @natmicrobiol.nature.com www.nature.com/articles/s41...
- Reposted by Jonathan PrunedaJust two more days to submit abstracts for the "PARP Family and ADP-ribosylation CSHL meeting. We have an amazing lineup of speakers. The majority of speakers are selected from abstracts. Don't miss out! meetings.cshl.edu/meetings.asp...
- Reposted by Jonathan Pruneda📝 Online now - the Review "Chemical biology approaches for protein tagging in mammalian cells" from Kaitlyn Toy, Jenna Beyer, and @gburslem.bsky.social. #SelfLabelingProteinTags #GeneticCodeExpansion #ncAAs #SplitInteins #SpatiotemporalControl Read it here 👉 authors.elsevier.com/a/1mRdq3S6Gf...
- Reposted by Jonathan PrunedaNew year, new preprint! 🎊 We are excited to share our recent work on #E3 ligase regulation in #metabolism! www.biorxiv.org/content/10.6... #ubiquitin #targetedproteindegradation #chemicalbiology 1/6
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- Reposted by Jonathan PrunedaJoin us for the #Ubiquitin & Friends Symposium 2026, April 29-30, in Vienna! Fantastic guest speakers👇 & many slots for talks from abstracts, flash-talks & posters. Lots of opportunities to network. Register now to save your spot! ➡️ www.protein-degradation.org/symposium/ #ubfriends2026
- Reposted by Jonathan PrunedaIncredibly excited to be taking part in the EMBO Workshop Pathogen Immunity & Signalling. Thanks to Annemarthe van der Veen, @kajastelab.bsky.social, @iannaconelab.bsky.social, @maurogaya.bsky.social, @manellab.bsky.social, @jnpruneda.bsky.social, Jan Rehwinkel & Mads Gyrd-Hansen for organising.
- Reposted by Jonathan PrunedaLearn more about the interplay between ADP-ribosylation and ubiquitination: PARG regulates proteasomal degradation of the ADP-ribosyl hydrolase TARG1 by preventing PAR-dependent ubiquitination mediated by the E3 ligases HUWE1 and TRIP12 www.sciencedirect.com/science/arti...
- Reposted by Jonathan PrunedaWhen RNA Degradation 🤝 meets 🤝 Protein Degradation! tinyurl.com/E3TDMD In a collaboration of @bartellab.bsky.social and Schulman lab, we show that, in target-directed microRNA degradation (TDMD), 2-RNA-factors recruit an E3 ligase and induce the degradation of not only a protein but also RNA (1/5).
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- Reposted by Jonathan PrunedaWhile everyone is hustling for the holidays, hopefully folks will have time to submit abstracts or register for #ASMMicrobe2026 in DC! Please repost!
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- Reposted by Jonathan PrunedaVery important 🧵 🧪 Amplifying for greater reach
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- Reposted by Jonathan PrunedaNIGMS R35 Maximizing Investigator's Research Award (MIRA) for Outstanding Investigators new NOFO is available!! Submission dates starting in January 2026 through May 2028. See link below: simpler.grants.gov/opportunity/...
- Reposted by Jonathan PrunedaI have a PhD position available with start date September 2026 at the University of Manchester. Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes Due to funding requirements, this position is for UK home students only. www.findaphd.com/phds/project...
- Reposted by Jonathan Pruneda🚨New faculty job opportunity 🚨 Please share this ad for a faculty position in our department at UC Irvine, in the fields of microbiology and infectious disease. MD/PhDs and PhDs are desired and should apply! recruit.ap.uci.edu/JPF09954
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- Reposted by Jonathan PrunedaExcited to share our work into ubiquitin E1-E2 specificity mechanisms. CryoEM visualising #ubiquitin transfer,biochemistry,evolution @labhofmann.bsky.social & tissue expression analyses @psarkies.bsky.social Big thanks to the team,reviewers & handling editor @dimitristypas.bsky.social rdcu.be/eTRdR
- Reposted by Jonathan PrunedaSAVE THE DATE! The EMBO workshop "Ubiquitin and Ubiquitin-like proteins in Health and Disease" will be on September 2026. Exciting line up of talks and an amazing location! Organised by @kulathu.bsky.social, @merbllab.bsky.social, @simonapolo.bsky.social, Claudio Joazeiro. Registration open soon.
- Reposted by Jonathan PrunedaFor all #ubiquitin aficionados out there: Our new study, where we used an #alphafold based screen and found a new class of plant-specific DUBs, which cleave K63 chains and interfere with endocytosis at the plasma membrane. www.biorxiv.org/content/10.6...
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- Reposted by Jonathan PrunedaA key step towards human genome synthesis. With thanks to @wellcometrust.bsky.social @mrclmb.bsky.social #SynHG doi.org/10.1126/scie...
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- Reposted by Jonathan PrunedaIn our latest study we show that ligand-activated transcription factor AHR (environmental sensor) is ADP-ribosylated by PARP7. This ADP-ribose mark is recognised by the E3 ubiquitin ligase DTX2 targeting AHR for proteasomal degradation, enabling cells to rapidly shut down AHR-mediated transcription.
