Matt Hall
🇦🇺 SD at NCATS, all about treatments for rare diseases, drug discovery and technologies. Views my own. Etc.
- Today we are hosting Dr Barbara Slusher from John’s Hopkins speaking about her drug discovery research programs - amazing scientist and a full house for her seminar !
- This made me happy. And happy new year!
- It’s buzzing like the first day of school!!!
- How did we get to a place where lower-case ‘l’ is an acceptable symbol for liter/litre?
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- Reposted by Matt HallMOFs are pretty darn cool. Here's our story, in @cenmag.bsky.social cen.acs.org/people/nobel...
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- Reposted by Matt HallThis October I’m drawing one molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social Day 2/31 Prompt WEAVE N-terminal domain of a Fibrion - a building block of silk fiber produced by silkworms. Pdb: 3UA0 Next prompt is CROWN and I would love your suggestions!
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- As a little boy, my grandparents gave me this book. This story of Pasteur is the one that made me want to be a scientist. And it doesn’t even mention optical activity!!
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- “dad can you can get me one of those retro digital cameras?”
- I missed this paper at the time but love this kind of study: "The total mass, number, and distribution of immune cells in the human body" "an average individual’s immune system consists of approximately 1.8 trillion cells, weighing around 1.2 kg" www.pnas.org/doi/10.1073/...
- I rarely post about work, but in writing this email today asking how to be reimbursed for the cost of hosting a scientific visitor I wrote this explainer. This is not a complaint - but shows how we have to use our own salaries to enrich our environment and the commitment that takes
- It’s that time of year again - NIH Research Festival !
- I must be doing something right - daughter raided my vinyl.
- Biomedikum @ki.se
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- I struggled with homesickness like this, and remember crying instantly once because there was a kangaroo on TV. It was always just beneath the surface. It took years for me to get through it. www.youtube.com/watch?v=gPXG...
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- I show this dedication in Volume 1 to 'Inorganic Syntheses' to the organic chemists whenever I can. Solid.
- I love getting into bed and thinking about all the things I didn’t do today
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- Proud of this new article from us in Nature, with long-term collaborators at Chicago and NCI "NNMT inhibition in cancer-associated fibroblasts restores antitumour immunity" www.nature.com/articles/s41...
- It’s take your kids to the gig night. My girls (15 and 13) seeing their first real gig tonight @dinosaurjr.com - AJ’s @snailmail.bsky.social who are giving wonderful Juliana Hatfield vibes !
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- It's amazing to me that one letter f is the difference between UNFAIR and FUNFAIR
- One thing that affects me reviewing: I’m no longer spending time working out how to log in to websites. Why are there separate logins for reviewers and authors? If I can’t log in easily to provide a review (ie my unpaid work) I’m work not to spend time solving that problem.
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- Am I the only scientist who likes to cool off in the coldroom on a hot day?
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- New paper from our group with Michael Gottesman and Rob Robey at NCI ; showing that most antibody-drug conjugate payloads are substrates of ATP-binding cassette drug efflux transporters www.biorxiv.org/content/10.1...
- The new NIH Director presents at his first Town Hall - and it’s a FULL HOUSE in the Clinical Center
- Farewell to Nate Hoxie, who leaves our group after an amazing period of time developing mass spec approaches for drug discovery and assay development. As is tradition for our group, Nate receives the complete Sherlock Holmes canon. Full of life lessons.
- ICYMI ; here at NIH we're back to recruiting the next generation of scientists to train in our labs - postbaccalaureate and postdoctoral fellows are sought right across NIH. Learn more here ! www.training.nih.gov/welcome-to-t...
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- Final sentences of an email by me tonight summarizing a paper. #reproducibility "Just because the compound was active in their discovery assay doesn’t mean it’s the reason the compound killed the cancer cells. Terrible. And the reviewers should be ashamed too."
- We've added another success - NUMBER 60 !!! - to our intramural list of FDA drug approvals and clinical trial clearances here at NCATS. Latest is cross-NIH partnership w/ Amy Newman at NIINDS with IND approved for VK4-116 for opioid use disorder. See all our success: ncats.nih.gov/research/our...
- New article from me w/ Min Shen & alum Dan Urban (now at Sanofi) out in Scientific Reports ; collab with Anjali Cremer at @goetheuni.bsky.social , and Kim Stegmaier @danafarber.bsky.social www.nature.com/articles/s41... Inflammatory signaling pathways play a role in SYK inhibitor resistant AML
- Nice article on repurposing opportunities - with Don Lo at EATRIS, former NCATS lead On the Doorstep of Pharmaceutical Cures That Will Boggle the Mind www.realclearmarkets.com/articles/202...
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- Started watching Farscape - I’m not normally a Sci Fi watcher, but liking how it starts:
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- So much science happening ; in our NCATS labs we've got a SciEx mass spec screening platform - and we've started HTS on a couple of new methyltransferase targets as part of a collaboration with NCI. The plates are stacking up and loading on to the mass spec as I type .
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- Picked this up from X: Rare diseases have a home at NCATS, was proud to light up Building 1 at the center of the NIH campus in recognition of #RareDiseaseDay. NCATS Director Joni Rutter, DRDRI Director Dominique Pichard are shown. #NIH
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- It's 👏 not 👏 a 👏 dose-response 👏 curve 👏 it's 👏 a 👏 concentration-response 👏 curve
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- movies you've watched more than six times, gifs only
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- I keep forgetting other people have weekends
