Dr. Natalie Tatum
🧬 senior postdoc with Endicott & Noble Lab [ t.ly/iinwc & t.ly/AAaA7 ]
💊 structure-based & computational drug discovery
💎 crystals, protein science
🏳️🌈 geek & mammy shark
📍Cancer Research Horizons Newcastle
📍Newcastle University
📣 Views mine
- Reposted by Dr. Natalie TatumNext up is Robbie Burton from Newcastle University
- Reposted by Dr. Natalie TatumJust published: Our paper on high-throughput analysis of cyclin docking interactions, led by the group of Norman Davey @icr.ac.uk and with some small-complex-plus-peptide #cryoEM by @natalia-mg.bsky.social from my lab. Congratulations, everyone! www.nature.com/articles/s41...
- 🧬 Engineered nanobodies binding and stabilizing cancer-mutant p16INK4a—without blocking its CDK6 interaction or cell-cycle arrest function, in press at Structure from Endicott @nucancer.bsky.social and @lauraitzhaki.bsky.social groups! 📖 www.cell.com/structure/fu...
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- Crystallography for the "dark proteome"? From @nudrugdiscovery.bsky.social and @chemistryncl.bsky.social : #FragLites map protein–protein interaction sites including regions with no previously known function. 🧵1/3 #DrugDiscovery #ChemBio 📖 www.sciencedirect.com/science/arti...
- While FragLites reliably bound to established interaction regions like the Palm site, ATP cleft, and RXL motif, we see a previously uncharacterized site at the CDK2–cyclin A interface. This site, rich in fragment engagement, may extend the SKP2 binding surface described by Kelso et al. (2021). 🧵 2/3
- Today was one of those Good Days in Academia where (a) an experiment gave me a result I was hoping for, which is Super Cool, and (b) an undergrad emailed asking for advice and I could give them resources and context to point them on the next step of their journey. Little important wins 🩷
- Reposted by Dr. Natalie TatumChatbots — LLMs — do not know facts and are not designed to be able to accurately answer factual questions. They are designed to find and mimic patterns of words, probabilistically. When they’re “right” it’s because correct things are often written down, so those patterns are frequent. That’s all.
- I'm at #DurhamHPCDays today to present in the Computational Biosciences workshop. Always lovely to come back to Durham, and this time to see a shiny new Maths+CompSci building!
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- @xtaldave.xtaldave.net.ap.brid.gy Your post to the ccp4bb is a thing of beauty.
- Latest preprint out in the wild! This is some older work which lingered on our to-do lists; we published the crystal structure of the human IRF4 DNA-binding domain (6TD4) in 2020!
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- Reposted by Dr. Natalie TatumA long post about what’s happening to the science funding agencies in the US and why. As mentioned, this one just kept getting longer even as I kept stripping curse words from it. www.science.org/content/blog...
- Reposted by Dr. Natalie TatumRead about our potential breakthrough in oncology - restoring wild type p53 function with ASTX295. This molecule was co-developed with Astex Pharmaceuticals, and is currently showing great phase I trial readout! #cancer #medchem #clinicaltrials www.linkedin.com/posts/cancer...
- Reposted by Dr. Natalie TatumOur research is critically dependent on funding we receive from @cancerresearchuk.org and we are also willing to do our bit towards fundraising. In 2024: Funds Raised: £6,440 (+£1,031 gift aid) Online Donations: 283 Events: Great North Run, Race for Life, Shine Walk, Leeds Marathon, bake sale, quiz
- Setting up some crystallisation plates today for a new year treat/Christmas miracle. First time setting up an in situ plate for some work with @diamondlightsource.bsky.social VMXi 💎
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- Been flying the @newcastleuni.bsky.social and @nudrugdiscovery.bsky.social flags recently, talking to @mosmedcdt.bsky.social Cohort 6 about applying computational methods appropriately + short talk at the Durham BSI bit.ly/4d7nlbB on our cyclin D3 work! bit.ly/3D6SwHF🧬🧶 #academicsky
- Reposted by Dr. Natalie TatumThrilled to share the new collaboration between @diamondlightsource.bsky.social + @crhorizons.bsky.social + @newcastleuni.bsky.social to accelerate structure-based drug development via fragment screening! More here: bit.ly/4g7Et3f 🧬🧶 #chemsky #chembio We're already hard at work on exciting targets 💪
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- Pleasure to be on the judging panel for the @mosmedcdt.bsky.social Project Ideation session! An excellent showcase of ideas from all of the teams. Congratulations to our winners, who really emphasised patient need and presented a clear way forward to address it. 👏
- Spent today with @newcastleuni.bsky.social development team on their new leadership induction course! Lots to take away and reflect upon 💪
- Reposted by Dr. Natalie TatumI am looking for 2 postdoctoral researchers to join my lab to work on the role of HIV-1 accessory proteins in the pathogenesis of HIV/AIDS and viral latency. Please contact me informally or ‘re-sky’ to anyone you think may be interested. Closing Dec 10th www.jobs.ac.uk/job/DKV639/p...
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- The Newcastle Drug Discovery group are on BlueSky! Follow for updates and insights and probably photos of funrunners and cakes 🧬🧶 #chemsky 🧪 #academicsky #chembio #biophysics
- Our multidisciplinary team, with strong industry links, specialises in structural fragment-based approaches for class-leading cancer drug discovery complemented by our strengths in synthetic chemistry, innovative target validation technologies & hit matter finding. research.ncl.ac.uk/drugdiscovery/
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- Done in the lab for today (multitasking a protein purification and setting up an SPR assay) so now I get to sit down, have a coffee, and start writing a fresh new talk for a symposium I'm speaking at in December! #ecrchat #academicsky 🧪 🧶🧬
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- Reposted by Dr. Natalie TatumBeware, this "BBC Breaking News" account is fake. It's not an official BBC News account. If BBC News ever joins this platform, it'll be publicised via official BBC platforms.
- Reposted by Dr. Natalie TatumThere’s a new Practical Cheminformatics post, “Some Thoughts on Dataset Splitting,” (with code and a robot cartoon) at practicalcheminformatics.blogspot.com/2024/11/some... .
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- Revisiting this post because while I did finish Northanger Abbey, I recently failed to beat my all time Pride and Prejudice record (25% 😅). I'm just not a Victorian prose girly.
- Reposted by Dr. Natalie Tatum⚠️THREAD OF ALL SCIENCE-RELATED STARTER PACKS! ⚠️ 🔄Share to help people finding its topic/field - STRUCTURAL BIOLOGY Structural Biology 1: bsky.app/starter-pack... Structural Biology 2: bsky.app/starter-pack... Crystallography: bsky.app/starter-pack... Synchrotron&CryoEM: bsky.app/starter-pack...
- Latest paper on CDK structural biology from the Endicott & Noble labs is in press at Structure! Good old fashioned mutational studies and fun newfangled AlphaFold modelling to characterise the interaction of CRABP2 with CDK4/6-Cyclin D3. 🧶🧬 #biophysics www.cell.com/structure/fu...
- I've been riding the high of a positive experimental result on Friday morning all through the weekend. One of those ones you weren't getting your hopes up about, but then you see something binds something else and the mutants don't and you do an involuntary little dance and maybe swear a bit. 🧶🧬
- Reposted by Dr. Natalie TatumDiscussing Bluesky migration in terms of liberal flight misses the simple fact that most people use social media for fun not influence and this platform, unlike X and cruddified Facebook, doesn’t feel like you’re wading through shit to reach your friends. It’s not that deep.
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- Preprint out now! We used FragLites to map a complex for which there are structurally characterised partner proteins and show how the FragLites are really good at (a) preferentially binding to PPI sites, and (b) mimicking hotspot interactions. This can help guide separation-of-function mutations!
- This this this!
- Kicking off the #mosmed24 conference @newcastleuni.bsky.social!
- It's conference week in our house: I'm home @newcastleuni.bsky.social for the MoSMed CDT conference #mosmed24, and I'm flying solo with the toddler while Husband is off to CHEMUK2024 in Birmingham! It's going to be a loooong couple of days 😅
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- My reading goal for April is to finish a Jane Austen novel, something I've never been able to do. I'm more than halfway through Northanger Abbey now, so it's just a matter of will-power. 💙📚 (Nothing against Austen btw, just find the style of 19thC prose so challenging for some reason.)
- Reposted by Dr. Natalie TatumThe boys and I figured we’d ask ChatGPT to help us solve a clue from the Times crossword.
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- Reposted by Dr. Natalie TatumLove Songs xkcd.com/2870
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- Also FAO 🧬🧶 - many excellent reviews on fragment-based drug discovery by pretty much every method there is.
- Delighted to have been included in Dan Erlanson's review of reviews for 2023 - and many of the others mentioned are going straight onto my new year reading list! practicalfragments.blogspot.com/2023/12/revi...
- Delighted to have been included in Dan Erlanson's review of reviews for 2023 - and many of the others mentioned are going straight onto my new year reading list! practicalfragments.blogspot.com/2023/12/revi...
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- There's something so lovely and hilarious about our 2yo repeating back our positive reinforcement when she sees us accomplish a task. Everyone needs a toddler to celebrate their mundane achievements with a "well done, mammy" or a "good job Daddy" 😅
- Many thanks to @laurencepearl.bsky.social for sharing a code to bring me aboard the good ship bluesky - definitely starting to fill the void I've felt in the months since leaving the Old App!
- Ooh, hey, that's me!
