Ben S. Huang
Explorer of the Black Box
- Reposted by Ben S. HuangNews from central Jersey: I'm running to represent New Jersey's 12th Congressional District. By entering the fray, I hope to bring ideas of repairing our frayed republic. Not only to defend it in 2026, but to build something stronger, for generations to come! samwang.substack.com/p/entering-t...
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- Reposted by Ben S. Huang𝗕𝗿𝗮𝗶𝗻-𝘄𝗶𝗱𝗲 𝗰𝗼𝗺𝗽𝘂𝘁𝗮𝘁𝗶𝗼𝗻𝘀 Spatially distributed and regionally unbound cellular resolution brain-wide processing loops in mice 𝗕𝗿𝗮𝗶𝗻 𝗿𝗲𝗴𝗶𝗼𝗻𝘀 𝗼𝗿 𝗱𝘆𝗻𝗮𝗺𝗶𝗰 𝘁𝗵𝗿𝗲𝗮𝗱𝘀? Dynamical processing winding through most brain regions. Looks like a must read. www.biorxiv.org/content/10.1... #neuroskyence
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- Reposted by Ben S. HuangI wrote a Comment on neurotheory, and now you can read it! Some thoughts on where neurotheory has and has not taken root within the neuroscience community, how it has shaped those subfields, and where we theorists might look next for fresh adventures. www.nature.com/articles/s41...
- Reposted by Ben S. HuangThrilled to share our new study showing microglia prune astrocyte processes in adult brain, to regulate synaptic transmission, hypothalamic neuron activity, and salt-induced hypertension in🐀. Huge team effort - congratulations to all🥂🍾🎉
- Reposted by Ben S. HuangThis is an airyscan confocal movie of mitochondria (white) moving around in a mouse astrocyte. Actin filaments are in orange and microtubules are in blue.
- Reposted by Ben S. HuangFlyBase needs your help! We ask that European labs continue to contribute to Cambridge, UK FlyBase, whereas US and other non-European labs can contribute to US FlyBase. For more information and how to donate: wiki.flybase.org/wiki/FlyBase...
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- Reposted by Ben S. HuangNew electron microscopy study in @nature.com Neuroscience finds that layer 5 ET neurons mostly connect to inhibitory cells locally, esp. those suppressing other excitatory cells, suggesting a "winner-take-all" system. 🧠📈 www.nature.com/articles/s41...
- Reposted by Ben S. HuangA big day for preventing mitochondrial diseases from transmitting to the next generation www.nature.com/articles/d41... www.nejm.org/doi/full/10.... www.nejm.org/doi/full/10.... www.nejm.org/doi/full/10....
- Reposted by Ben S. HuangYour sleep pressure is powered by your mitochondria! Sleep, energy, and ageing are all connected through mitochondrial bioenergetics in neurons. Brilliant work from Gero Miesenböck’s lab, just out in Nature @nature.com www.nature.com/articles/s41...
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- Reposted by Ben S. HuangA few weeks ago, I talked to @neildegrassetyson.com on his StarTalk Radio about our efforts to understand human brain disorders with stem cell models including #assembloids. We touched on the promise of these technologies, the challenges & the mission behind the work www.youtube.com/watch?v=HEBj...
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- Reposted by Ben S. HuangThe dynamics and geometry of choice in the premotor cortex 🧠 Nature 2025 #neuroskyence www.nature.com/articles/s41...
- CryoRhodopsins: A comprehensive characterization of a group of microbial rhodopsins from cold environments www.science.org/doi/10.1126/...
- Reposted by Ben S. HuangYour brain learns for you even when you're not actively learning. Maybe. (in mice).
- 🚶Aimlessly wandering around a city or exploring the new mall may seem unproductive, but new research led by @zh0ng0.bsky.social @marius10p.bsky.social @computingnature.bsky.social suggests it could play an important role in how our brains learn. 🧠 🔗 www.janelia.org/news/zoning-...
- Reposted by Ben S. HuangOur new paper out now in Science explores how neural activity in the lateral entorhinal cortex (LEC) *drifts* over time - and *jumps* at key boundaries - to help organize events in memory. 🔗 www.science.org/doi/10.1126/... Here's a quick summary of what we found 🧵👇
- Your brain doesn’t just passively track time ⏳ - it structures it. In @Science.org we show that activity in 🧠 memory circuits (LEC) drifts constantly, but makes sharp jumps at key moments, segmenting life into meaningful events. (1/2) 👉 www.science.org/doi/10.1126/...
- Reposted by Ben S. HuangNature research paper: Nerve-to-cancer transfer of mitochondria during cancer metastasis go.nature.com/46c474I
- Reposted by Ben S. HuangYour brain doesn’t just passively track time ⏳ - it structures it. In @Science.org we show that activity in 🧠 memory circuits (LEC) drifts constantly, but makes sharp jumps at key moments, segmenting life into meaningful events. (1/2) 👉 www.science.org/doi/10.1126/...
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- Reposted by Ben S. HuangOur groundbreaking Dark Sectioning technique is now published in Nature Methods! 🎉 It supercharges existing imaging systems: 🔬 Widefield → Confocal 🔬 Single-photon → Multiphoton 🔬 2D-SIM → 3D-SIM Now integrated in Airy PolarSIM and #FlexSIM! doi.org/10.1038/s415... #Microscopy #Fluorescence
- Reposted by Ben S. HuangGrid cells have a geometry in time. Thanks to @azvollan.bsky.social l & @rjgardner.bsky.social for this heroic discovery. @ercresearch.bsky.social #KiloNeurons @m-bmoser.bsky.social @kavlintnu.bsky.social @nature.com @kavlifoundation.bsky.social www.nature.com/articles/s41...
- Reposted by Ben S. Huang1/6 Why does the brain maintain such precise excitatory-inhibitory balance? Our new preprint explores a provocative idea: Small, targeted deviations from this balance may serve a purpose: to encode local error signals for learning. www.biorxiv.org/content/10.1... led by @jrbch.bsky.social
- Reposted by Ben S. HuangMy med school textbook says stimulants like Ritalin treat hyperactivity by “stimulating” the brain’s attention and cognitive control systems. We studied children taking stimulants in the ABCD Study, and the largest differences were actually in arousal and reward networks! Check out our preprint!
- Reposted by Ben S. HuangHappy 99th birthday to the man who gave voice to the wild. 🎉 Sir David Attenborough, thank you for a lifetime dedicated to the natural world, and for sharing its story with wisdom, wonder, and grace. You've inspired generations to fall in love with nature.
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- Reposted by Ben S. HuangACTION ITEM-----ACTION ITEM Implementation of Schedule F This is what a lot of us have been worried about. This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs. BUT THERE IS A COMMENT PERIOD... 1/n
- Reposted by Ben S. HuangAnother image from this incredible foggy morning at the iconic Mont Saint Michel last week… #photography #art #landscape #history #myregion
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- Reposted by Ben S. HuangThe brain as it's never been seen before. Scientists have created the largest wiring diagram and functional map of a mammal brain to date. 🧠📈 @princetonneuro.bsky.social @jhuapl.bsky.social @uwgradschool.bsky.social @bcmfromthelabs.bsky.social @unigoettingen.bsky.social
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- Reposted by Ben S. HuangA tour de force study from Taipale&Yin labs. It expands the vocabulary of the Regulatory Code by adding 1131 TF:TF composite motifs that are different from the individual TF motifs. The new composite motifs are enriched in cell-type specific elements and active in vivo www.nature.com/articles/s41...
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- Reposted by Ben S. HuangHow do we associate the flavors we experience during a meal 🍽️😋 with postingestive effects like food poisoning 🤢🤮 that arise much later? Our answer in @nature.com this week: Illness signals from the gut reactivate and strengthen flavor representations in the amygdala. 📄: nature.com/articles/s41...
- Reposted by Ben S. HuangInflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety: @cellpress.bsky.social www.cell.com/cell/fulltex...
- Reposted by Ben S. Huang🥼 Janelia researchers led by @boazmohar.bsky.social @nspruston.bsky.social @rhodamine110.bsky.social & @svoboda314.bsky.social @alleninstitute.bsky.social have developed a new imaging tool that maps brain-wide changes in neuronal connections. 🧠 🔗 www.janelia.org/news/new-ima...
- Reposted by Ben S. Huang✨ Announcing a new glutamate indicator - iGluSnFR4! ✨ Launched as a pair, iGLuSnFR4s and iGluSnFR4f have high-sensitivity and fast activation/deactivation for recording synapses. More on the indicators and what they are already revealing: www.biorxiv.org/content/10.1... 🧠📈
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- Reposted by Ben S. HuangMany of us use 2p scopes to image 3D volumes of brain. But then we analyze the data plane by plane, resulting in duplicated neurons, missed neurons, and low s/n. Let's go 3D! Suite3D: Volumetric cell detection for two-photon microscopy by @haydari.bsky.social & team. www.biorxiv.org/content/10.1...
- Reposted by Ben S. HuangHere at Princeton, we’re amplifying our university president’s leadership. It’s time for everyone - faculty, students, staff - to speak out. tl;dr: rights can’t be blackmailed. From me and science colleagues: www.dailyprincetonian.com/article/2025...
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