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Mychael Lourenco

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Neuroscientist studying molecular mechanisms of Alzheimer’s disease and related disorders. Assistant Professor at UFRJ, Brazil. www.lourencolab.org

Joined November 2024

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Argel Aguilar Valles argelaguilarvalles.bsky.social · Mar 17, 2025
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Mychael Lourenco handle.invalid · Mar 17, 2025
www.nature.com/articles/s41...
Social disadvantage accelerates aging - Nature Medicine

Individuals with social disadvantage, during both early and later life, have an increased risk of 66 age-related diseases mediated by 14 age-related proteins.

nature.com

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Andrew Octavian Sasmita aosasmita.bsky.social · Mar 15, 2025
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Mychael Lourenco handle.invalid · Mar 14, 2025
Happy to be in Taipei for the @embo.org Workshop - Neural development and neurodegeneration!

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Waggoner Lab labwaggoner.bsky.social · Mar 5, 2025
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caramellipaulo caramellipaulo.bsky.social · Feb 5, 2025
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caramellipaulo caramellipaulo.bsky.social · Feb 7, 2025
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Mychael Lourenco handle.invalid · Jan 27, 2025
Our comment on a very interesting @elife.bsky.social paper showing how S1PR signaling may underlie pain-associated memory impairment is now out! Check it out! elifesciences.org/articles/105...
Pain-Related Memory Impairment: How does chronic pain lead to memory loss?

A dysfunctional signaling pathway in the hippocampus has been linked to chronic pain-related memory impairment in mice.

elifesciences.org

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Mychael Lourenco handle.invalid · Jan 27, 2025
You can also read the original paper here: elifesciences.org/articles/99862
Dysfunctional S1P/S1PR1 signaling in the dentate gyrus drives vulnerability of chronic pain-related memory impairment

RNA-Seq analysis and molecular biological approaches reveal a novel mechanism and provide a promising preventive and therapeutic molecular target for vulnerability to chronic pain-related memory impai...

elifesciences.org

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Mychael Lourenco handle.invalid · Jan 9, 2025
Happy to share this study led by Betty Bigio, Carla Nasca (NYU) and our team @ufrjoficial.bsky.social just published in Molecular Psychiatry. Here, using two cohorts, we show that plasma carnitine levels are reduced in women with cognitive impairment and dementia. www.nature.com/articles/s41...
Sex differences in mitochondrial free-carnitine levels in subjects at-risk and with Alzheimer’s disease in two independent study cohorts - Molecular Psychiatry

Molecular Psychiatry - Sex differences in mitochondrial free-carnitine levels in subjects at-risk and with Alzheimer’s disease in two independent study cohorts

nature.com

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Dena Dubal handle.invalid · Jan 8, 2025
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Shannon Macauley macauleylab.bsky.social · Jan 7, 2025
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Giulio Maria Pasinetti, MD, PhD giuliompasinetti.bsky.social · Jan 6, 2025
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Eduardo Zimmer erzimmer.bsky.social · Jan 7, 2025
Our spotlight on @cp-trendsneuro.bsky.social, commenting on this great article by the Herfert Group 👇
- Trends in Neurosciences handle.invalid · Jan 6, 2025
  ‘Assessing brain-wide outcomes of dopamine system activation in the living rodent brain’ TINS ‘Spotlight’ by @limberger-chris.bsky.social & @erzimmer.bsky.social www.cell.com/trends/neuro... discussing Haas, Bravo, et al., 2024, Kristina Herfert group www.science.org/doi/10.1126/...
  Assessing brain-wide outcomes of dopamine system activation in the living rodent brain
  
  In a recent study, Haas, Bravo, and colleagues integrated optogenetic stimulation with simultaneous functional in vivo positron emission tomography (PET)/magnetic resonance imaging (MRI) measurements in rats. By activating the nigrostriatal pathway in the substantia nigra pars compacta (SNc), they observed concurrent metabolic and hemodynamic fluctuations associated with the dopaminergic pathway in living animals at the whole-brain level.
  
  cell.com
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Mychael Lourenco handle.invalid · Jan 1, 2025
Happy 2025 to all my colleagues and friends here!

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Mychael Lourenco handle.invalid · Dec 24, 2024
Happy Christmas to all those who celebrate! I hope you all have a great season.

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Mychael Lourenco handle.invalid · Dec 23, 2024
www.biorxiv.org/content/10.1...
RNA encodes physical information

Most amino acids are encoded by multiple codons, making the genetic code degenerate. Synonymous mutations affect protein translation and folding, but their impact on RNA itself is often neglected. We ...

biorxiv.org

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Lance Johnson johnsonlab.bsky.social · Dec 21, 2024
new preprint! www.biorxiv.org/content/10.1... a characterization of APOE effects on the lipid droplet-ome (turns out you see a lot of "AD-related" proteins!) first authors Cassi Friday & Isaiah Stephens + great collaborators Scott Gordon, @cohenlaboratory.bsky.social @morganti.bsky.social

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Mychael Lourenco handle.invalid · Dec 21, 2024
www.sciencedirect.com/science/arti...
Periodic ER-plasma membrane junctions support long-range Ca2+ signal integration in dendrites

Neuronal dendrites must relay synaptic inputs over long distances, but the mechanisms by which activity-evoked intracellular signals propagate over ma…

sciencedirect.com

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Mychael Lourenco handle.invalid · Dec 18, 2024
www.jneurosci.org/content/37/1...
Heroes of the Engram

In 1904, Richard Semon introduced the term “engram” to describe the neural substrate responsible for (or at least important in) storing and recalling memories (i.e., a memory trace). The recent introd...

jneurosci.org

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Mychael Lourenco handle.invalid · Dec 10, 2024
www.cell.com/cell-reports...
Microglia degrade Alzheimer’s amyloid-beta deposits extracellularly via digestive exophagy

Jacquet et al. shows that microglia use digestive exophagy to engage large Aβ deposits that cannot be phagocytosed, forming acidic extracellular compartments on the aggregates into which lysosomal enzymes are exocytosed. The PI3K-AKT pathway modulates this process. Microglia also exocytose intralysosomal undigested fibrillar Aβ toward extracellular aggregates, potentially contributing to plaque growth.

cell.com

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gaborpetzold gaborpetzold.bsky.social · Dec 9, 2024
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bioRxiv Neuroscience handle.invalid · Dec 9, 2024
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Mychael Lourenco handle.invalid · Dec 6, 2024
www.nature.com/articles/s41...
Understanding the molecular diversity of synapses - Nature Reviews Neuroscience

The set of proteins present at synapses determines their heterogeneous functions and properties. In this Review, van Oostrum and Schuman describe the molecular mechanisms that contribute to the d...

nature.com

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Mychael Lourenco handle.invalid · Dec 2, 2024
Important findings from the investigational AL-002 trial. These results, though disappointing in terms of clinical outcomes, may substantially inform future approaches and help us better understand Alzheimer's pathophysiology. investors.alector.com/news-release...
Alector Announces Results from AL002 INVOKE-2 Phase 2 Trial in Individuals with Early Alzheimer’s Disease and Provides Business Update | Alector

SOUTH SAN FRANCISCO, Calif. , Nov. 25, 2024 (GLOBE NEWSWIRE) -- Alector, Inc. (Nasdaq: ALEC), a clinical-stage biotechnology company pioneering novel, genetically validated therapies for the treatment...

investors.alector.com

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Thiago Carvalho cyrilpedia.bsky.social · Dec 2, 2024
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Jason Shepherd handle.invalid · Dec 2, 2024
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Michael Ward handle.invalid · Nov 21, 2024
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Mychael Lourenco handle.invalid · Nov 19, 2024
Interesting story!
Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy

RNA splicing enables the functional adaptation of cells to changing contexts. Impaired splicing has been associated with diseases, including retinitis pigmentosa, but the underlying molecular mechanis...

science.org

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Mychael Lourenco handle.invalid · Nov 19, 2024
Candid comments by @eisch.bsky.social on our recent findings. Worth reading this candid assessment, if you're interested in the topic. Very nice to see this kind of balanced short review. Something we should do more often.
- Amelia Eisch 🧪🧠👩‍🔬 🐁 eisch.bsky.social · Nov 18, 2024
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Shannon Macauley macauleylab.bsky.social · Nov 19, 2024
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Mychael Lourenco handle.invalid · Nov 17, 2024
I'd like to share this recent paper from our group implicating impairments in translational control mechanism in depressive-like behavior. Check it out if you're interested in the topic! www.nature.com/articles/s41...
Defective regulation of the eIF2-eIF2B translational axis underlies depressive-like behavior in mice and correlates with major depressive disorder in humans - Translational Psychiatry

Translational Psychiatry - Defective regulation of the eIF2-eIF2B translational axis underlies depressive-like behavior in mice and correlates with major depressive disorder in humans

nature.com

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Eduardo Zimmer erzimmer.bsky.social · Nov 16, 2024
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