Roux Lab, Geneva
A mix of physics and biology, understanding shapes in biology, from molecules to tissues.
http://www.orelrouxlab.org
- You should also read Juanma’s paper, which visualizes membrane tension gradients in migrating and non-migrating cells! rdcu.be/e2u20 It also shows that flipper truly reports tension, but that response varies with lipid composition.
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- Guillaume Pernollet shows that epithelial cells adjust their shape to locally flatten, forming scutoids for any geometry, changing our view of cell packing. Thanks to all! @clairedessalles.bsky.social @juanmagararc.bsky.social @sciencesunige.bsky.social www.biorxiv.org/content/10.6...
- @marineluciano.bsky.social recreates intestinal Villi geometry by growing epithelial cells on wavy rolling substrates. Unexpected intrication of curvature effects is observed. Thanks to all! @caterinatomba.bsky.social @sgabriele.bsky.social @sciencesunige.bsky.social www.biorxiv.org/content/10.6...
- Reposted by Roux Lab, GenevaPaper alert: Our study led by @evapillai.bsky.social and @sudimukherjee.bsky.social showing that mechanical properties of the #brain actively shape the molecular landscape during development and #axonpathfinding is finally out! www.nature.com/articles/s41... @pdncambridge.bsky.social @fau.de @MPZPM
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- A fantastic opportunity to work in Geneva if you are in the field of origins of life!
- 📢 Open faculty position – Origins of Life We have an opening in our section at the University of Geneva! 🧬🚀 SPREAD THE WORD Apply here: jobs.unige.ch/www/wd_porta...
- Reposted by Roux Lab, GenevaToday, our animation synthesizing decades of research on actin-mediated endocytosis in budding yeast was published: journals.biologists.com/jcs/article/... The result of a fantastic Iwasa-Drubin lab collaboration. @margotriggi.bsky.social @jiwasa.bsky.social movie.biologists.com/video/10.124...
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- Reposted by Roux Lab, GenevaAll credits to the dreamteam that made this possible! what a pleasure and honor working with these people! 🥰 @diorgeps.bsky.social @mhakala.bsky.social @juanmagararc.bsky.social @joshuatran.bsky.social @mudgal17.bsky.social @Carlos Marcuello @Andrea Merino
- Reposted by Roux Lab, GenevaThe crucial test: We fused Heimdall Hofund to a fission-defective yeast ESCRT-III protein (Did2). This chimera restored Mup1 trafficking to vacuoles back to wt! A short amphipathic helix, present in Asgard and retained as fragments in eukaryotes, acts as a minimal membrane fission trigger!
- Reposted by Roux Lab, GenevaEukaryotic ESCRT-IIIA paralogs, known to form heteropolymers, retain Hofund elements at their N-termini. In yeast, mutating these elements blocks ESCRT-III-dependent Mup1 transport to vacuoles. So these elements matter in eukaryotes too.
- Reposted by Roux Lab, GenevaIs this Asgard-specific, or conserved with their eukaryotic paralogs? Hard to tell, since the exact molecular mechanism of fission by eukaryotic ESCRT-III remains blurry, probably due to its complexity. Let’s figure it out!
- Reposted by Roux Lab, GenevaMeet Hofund, the N-terminal amphipathic helix of 15 aa in Heimdall ESCRT-IIIA (named after Heimdall’s sword). How do we know Hofund is the molecular trigger for fission? Remove Hofund → ESCRT-IIIA loses fission activity. Add Hofund alone → uncontrolled fission.
- Reposted by Roux Lab, GenevaThrough membrane fission! We show in vitro that the Asgard Heimdallarchaeota (Heimdall) ESCRT-IIIA subunit is inherently capable of triggering fission upon subunit turnover driven by ATP hydrolysis by Vps4. And the key question: what actually destabilizes the membrane when ESCRT-IIIA turns over?
- Reposted by Roux Lab, GenevaIn a recent work, @buzzbaum.bsky.social and colleagues showed an Asgard archaeon with internal vesicles. www.biorxiv.org/content/10.1... How might Asgard ESCRT-III have contributed to compartmentalization?
- Fantastic work from Javier @javierespadas.bsky.social in collaboration with @buzzbaum.bsky.social and @kaksonen.bsky.social labs, thank you Chris Toret, thank you Diorge @diorgeps.bsky.social!
- New preprint from the lab!!🎉 We show that Asgard archaea ESCRT-III proteins can trigger membrane fission and reveal its molecular mechanism, offering clues to how these cells may have built internal compartments. But do these organisms even have these compartments? www.biorxiv.org/content/10.1...
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- Reposted by Roux Lab, GenevaMicrofluidic pumping with active nematics! Self-organized and self-sustained. No external pumps. @pnas.org @ub.edu www.pnas.org/doi/10.1073/... #ActiveMatter #Microfluidics #SoftMatter
- Maria Tettamanti shows that inhibition of TORC2 by the small amphipath PalmC induces the TORC2-dependent internalization of sterols. Congrats to Maria and all coworkers involved, and to EMBOj for the efficient review process: use review commons! @biology-unige.bsky.social @sciencesunige.bsky.social
- Yeast cells utilize a TORC2 feedback loop for plasma membrane adaptation to mechanical stress, with increased sterol transport from plasma membrane to endoplasmic reticulum activating TORC2 signaling Robbie Loewith, Aurélien Roux @rouxlab.bsky.social and coworkers www.embopress.org/doi/full/10....
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- Reposted by Roux Lab, Geneva Congratulations @centriolelab.bsky.social @dudinlab.bsky.social and @gautamdey.bsky.social for your publication in @cp-cell.bsky.social: Charting the landscape of #cytoskeletal diversity in #microbial eukaryotes #Expansion #Microscopy @sciencesunige.bsky.social www.unige.ch/medias/en/20...
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- Reposted by Roux Lab, Geneva🚨 New preprint out! “Fluorescence lifetime estimation: a practical approach using Flipper-TR FLIM” with Tithi Mandal and @rouxlab.bsky.social We benchmark and describe step-by-step Flipper-TR FLIM measurements across different set-ups and and strategies. www.biorxiv.org/content/10.1...
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- Reposted by Roux Lab, GenevaUndergraduate/internship/master's thesis position: jobs.helsinki.fi/job-invite/4...
- Reposted by Roux Lab, GenevaPhD student position: jobs.helsinki.fi/job-invite/4...
- Reposted by Roux Lab, GenevaI have a PhD student and an undergrad student positions open at the Institute of Biotechnology @helsinki.fi We are using reconstitution, cell and structural biology to study protein-membrane interactions and membrane microdomain formation. Links to calls below! Feel free to drop a message and share!
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- Nice discussions after the talk given online yesterday at cytophys.org, presenting the work of @pauguillamat.bsky.social @clairedessalles.bsky.social @yamini-ravichan.bsky.social @oriolmb.bsky.social and Tithi Mandal. Available on the lab youtube channel at: youtu.be/g-7HomnPdtk
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- Reposted by Roux Lab, GenevaThe @embo.org ESCRT meeting was packed with membrane remodeling from every branch of the tree of life🌳. Some awesome science 🧪 highlights in the next posts 🧵. But a first impression… the venue!! Wow, Caux castle up a cogwheel train, overlooking Lac Léman! Perfect! 🌄 Thank you @rouxlab.bsky.social 🤗
- What a fantastic ESCRT meeting, the field is going strong and full of exciting science. Many thanks to @rouxlab.bsky.social @cellarchlab.com @jujumathieu.bsky.social @magromayor.bsky.social @majarad.bsky.social for organising such a a great event
- Reposted by Roux Lab, GenevaWhat a fantastic ESCRT meeting, the field is going strong and full of exciting science. Many thanks to @rouxlab.bsky.social @cellarchlab.com @jujumathieu.bsky.social @magromayor.bsky.social @majarad.bsky.social for organising such a a great event
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- Reposted by Roux Lab, GenevaThis was a truly exciting talk from Aurelien Roux @rouxlab.bsky.social from Univ. Geneva 👏👏. From his landmark work on membranes to tissues now, the continuing theme is the role of geometry, topology and curvature in morphogenesis. Thanks for visiting us 🤩
- Reposted by Roux Lab, GenevaThe amazing tour de force of the great @lcferme.bsky.social is now out in its final form in @ScienceAdvances (not on Bluesky???). It was hard work and all the conceptual advance was her doing. Check it out: www.science.org/doi/epdf/10....
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- Abstract submissions for short talks are still opened until April 20th for the EMBO Escrt meeting 2025. There are plenty of options for short talks, please apply online at meetings.embo.org/event/25-escrt
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- A short reminder that registrations for the EMBO ESCRT meeting 2025 in Montreux June 23rd-June27th are still opened! Please register online at meetings.embo.org/event/25-escrt
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