Javier Espadas
EMBO postdoc in @RouxLab.bsky.social, exploring the mechanics of membrane remodeling and its evolutionary implications. Skiing, climbing, and running in my free time
- Reposted by Javier Espadasfinishing with a path to multicellularity via ultrastructure complexity #cellbiologyofeukaryogenesis @sbcf.bsky.social a big thank you to all speakers!
- Reposted by Javier Espadasfrom viruses to lipid transfer and multiple symbiosis in early eukaryotes... #cellbiologyofeukaryogenesis @sbcf.bsky.social
- Reposted by Javier Espadasnext step about ins and outs of symbiosis in eukaryogenesis #cellbiologyofeukaryogenesis @sbcf.bsky.social
- Reposted by Javier Espadasfantastic start for our Eukaryogenesis meeting with a vivid overview of membrane remodelling systems in Archae!
- Reposted by Javier EspadasToday at 17:00 CET - the first #MembraneTrafficking seminar of 2026. Giovanni D’Angelo (EPFL) and Sean Munro (MRC-LMB), explore protein trafficking, retention, and sorting at the Golgi. Join us for exciting discussions about the best organelle! Details at felixcampelo.wixsite.com/membranetraf...
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- Reposted by Javier EspadasA reminder to sign up for the 2026 EMBO archaeal meeting im Cambridge: meetings.embo.org/event/26-arc.... Registration is open. We are looking forward to hosting you!
- Reposted by Javier Espadas🚨 Want to know how we demonstrated the importance of sterol-rich membrane microdomains for M. marinum infection? Check out our latest paper published in Science Advances 👇 www.science.org/doi/10.1126/... ✨ Big thanks to everyone, especially Cristina Boehm-Bosmani, @soldatilab.bsky.social ! ✨
- Reposted by Javier Espadas1. As we recently joined BlueSky, we want to repost this story for all newcomers! We sat down with @radler92.bsky.social to get more insight into the unique videos from his recent preprint on Promethearchaeota (formerly Asgard archaea). doi.org/10.1101/2025... (Videos and info below)
- Reposted by Javier EspadasAre you a long-time fan of Archaea, an extremophile-phile, or are you simply curious? Either way, we have good news. We’re delighted to announce the 2026 EMBO Workshop on Archaea, 6–10 July. Sign up: meetings.embo.org/event/26-arc... We look forward to seeing you in Cambridge, UK. Please repost!
- Congrats Omaya!! 👏🏼👏🏼👏🏼👏🏼
- Reposted by Javier EspadasAn Asgard Archaeon (Lokiarchaeum ossiferum) growing and retracting its arms
- Reposted by Javier EspadasAnd ‘Searching for the Asgards’ the movie: www.youtube.com/watch?v=mgmE...
- Reposted by Javier EspadasAn 8-nm precise map in live cells, which revealed #actin aster formation by #myosin V-driven transport of #formin. Happy to see this work now out! 😃 In collaboration with @kaksonen.bsky.social lab #yeast #pombe #cell_fusion @biology-unige.bsky.social
- New work by @valthomas.bsky.social et al. in @sophiemartinlab.bsky.social provides a live, 8-nm precision map of the actin fusion focus for cell-cell fusion in S. #pombe. This reveals #actin aster formation by #myosin Myo52-driven transport of the formin Fus1 nucleator rupress.org/jcb/article/...
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- New preprint from the lab!!🎉 We show that Asgard archaea ESCRT-III proteins can trigger membrane fission and reveal its molecular mechanism, offering clues to how these cells may have built internal compartments. But do these organisms even have these compartments? www.biorxiv.org/content/10.1...
- In a recent work, @buzzbaum.bsky.social and colleagues showed an Asgard archaeon with internal vesicles. www.biorxiv.org/content/10.1... How might Asgard ESCRT-III have contributed to compartmentalization?
- Through membrane fission! We show in vitro that the Asgard Heimdallarchaeota (Heimdall) ESCRT-IIIA subunit is inherently capable of triggering fission upon subunit turnover driven by ATP hydrolysis by Vps4. And the key question: what actually destabilizes the membrane when ESCRT-IIIA turns over?
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View full thread@colomlab.bsky.social @labvanni.bsky.social @kaksonen.bsky.social @buzzbaum.bsky.social @Christopher Toret @rouxlab.bsky.social Thank you all for the amazing work!!
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- Reposted by Javier EspadasNew paper from the @rouxlab.bsky.social on Nature Communications! We study how membrane tension is spatially organized in cells. Using the mechanosensitive probe Flipper-TR to visualize tension across the plasma membrane of adherent cells and to dissect the conditions needed for a gradient to happen
- Reposted by Javier Espadas🚨 Preprint alert 🚨 Don’t miss our latest story on how mycobacterial surface shedding shapes the host response !
- What an amazing work!! Excited to see it out after seeing how much hard work has been done here, and the result of it is equally impressive!! Congrats to all authors!!!
- Reposted by Javier EspadasLaunching celldynamicslab.com, the homepage of our new group at EPFL working on cell fragmentation, membrane and cortex mechanics, FLIM imaging, and microfluidics tools. MSc/PhD or postdocs interested in quantitative cell biology are welcome to reach out. We're also hiring a lab manager in 2026!
- Reposted by Javier EspadasMaria Tettamanti shows that inhibition of TORC2 by the small amphipath PalmC induces the TORC2-dependent internalization of sterols. Congrats to Maria and all coworkers involved, and to EMBOj for the efficient review process: use review commons! @biology-unige.bsky.social @sciencesunige.bsky.social
- Yeast cells utilize a TORC2 feedback loop for plasma membrane adaptation to mechanical stress, with increased sterol transport from plasma membrane to endoplasmic reticulum activating TORC2 signaling Robbie Loewith, Aurélien Roux @rouxlab.bsky.social and coworkers www.embopress.org/doi/full/10....
- An Asgard archaeon containing internal membrane compartments!! 😯 This will reshape our understanding of how the eukaryotic endomembrane system originated. Congrats to @buzzbaum.bsky.social, @tbharat-lab.bsky.social and all ppl involved! www.biorxiv.org/content/10.1...
- Reposted by Javier EspadasAn Asgard archaeon with internal membrane compartments Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors! www.biorxiv.org/content/10.1...
- Reposted by Javier EspadasThis is a glimpse of the cytoskeletal structures we found doing U-ExM in more than 200 species, now in Cell🤩: shorturl.at/6oHvi Amazing collaboration between @centriolelab.bsky.social , @dudinlab.bsky.social and @gautamdey.bsky.social labs. I believe last one is a 🕷️ #FluorescenceFriday #Microscopy
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- Reposted by Javier Espadas🚨Our collaboration with @centriolelab.bsky.social & @gautamdey.bsky.social is out today in @cp-cell.bsky.social We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny. #ProtistsOnSky #SciComm #SciSky www.cell.com/cell/fulltex...
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- Reposted by Javier EspadasPlease RT. Post-doc opportunity alert! 💥 closing 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems. For more details and to apply please see www.imperial.ac.uk/jobs/search-...
- Reposted by Javier EspadasLab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️ Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
- Reposted by Javier Espadas📢 New preprint ! Please check if you are interested in the comparison between 2d and 3d nematic theories 🤔 I show that the 2d description can lead to artefacts on curved surfaces, and I propose a thin film description of nematic shells with full 3d orientation ! This was a funny summer project 😊
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- 😯😯😯 beautiful work!
- It is out! 🦚 I recorded hundreds of #ExM 🔬images of cytokinetic bridges and averaged them into 6 stages. How? With help from our fantastic collaborators @zacsimile.bsky.social and @jonasries.bsky.social in Vienna 😇. Check out the full atlas here: doi.org/10.5281/zenodo.17232370
- Reposted by Javier EspadasAttention membrane traffickers! I'm recruiting a post-doc to my lab in Dundee. We're dissecting the functions of intrinsically disordered domains of COPII coat proteins. We think they control timing of coat assembly and morphology of carriers. www.dundee.ac.uk/work-for-us/...
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- Reposted by Javier Espadas🚨 New preprint out! “Fluorescence lifetime estimation: a practical approach using Flipper-TR FLIM” with Tithi Mandal and @rouxlab.bsky.social We benchmark and describe step-by-step Flipper-TR FLIM measurements across different set-ups and and strategies. www.biorxiv.org/content/10.1...
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- Reposted by Javier EspadasOne of the most exciting discoveries from our lab so far is now online as a preprint! Read a story on how the ParMR and Min systems started to collaborate to create the CorMR cytoskeleton, which now controls cell shape in multicellular cyanobacteria: www.biorxiv.org/content/10.1...
- Nice one!! 👏🏼
- How does evolution shape ancient cellular processes? Our new paper uncovers the mosaic evolution of conserved and diverging endocytic traits in fungi! www.cell.com/current-biol...
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- This is great Felix!!! Really happy for you!👏🏼🎉
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