Suliana Manley
Professor of physics and bioengineering @EPFL. Microscopy and mitochondria devotee. This view is all mine.
- I’m honored to be part of the next GRS Single Molecule Approaches to Biology, thanks Chairs @qmsmith.bsky.social and Alba Gomez Segalas for organizing this great event! The GRS is a wonderful opportunity for young scientists to share their exciting science and build communities. See you there!
- 🗣️ Keynote Speaker: @sulianamanley.bsky.social 👥 Mentoring Session: Careers Across Biophysics featuring @valdavinson.bsky.social @timcraggs.bsky.social @sulianamanley.bsky.social @esisamakis.bsky.social 📈 Selected talk and poster presenters: You! ☀️ Please repost, share and we'll see you in June!
- @lycasworks.bsky.social developed quantitative expansion (qExM) to estimate endogenous protein quantities in situ. His ExM protocols offer epitope preservation and accessibility so that standard Western Blot antibodies can be used. Also, check out the cristae, supercomplexes, specialized mitos 🤩
- 🔬🚨New preprint alert! 🚨🔬 We developed quantitative expansion microscopy (qExM) - a method to accurately count proteins in situ by combining expansion microscopy's improved labeling with statistical estimators borrowed from ecology www.biorxiv.org/content/10.6... #SuperResolution #CellBiology
- Ultra excited to launch an ERC Synergy project with amazing partners Kai Johnsson @mpi-mr.bsky.social & Wanda Kukulski @unibe.ch! MitoContact will reveal how contacts between identical organelle partners can yield a diversity of important functions, via dynamics, structure and physiology.
- I’m excited about this unique meeting, which will bring together some of my favorite scientists working on organelle biophysics and mechanics! I hope to see some of you in beautiful Barcelona in February. Deadlines have been extended: Dec. 8 abstracts Dec. 20 registration
- Sign up now for EMBO Workshop "Intracellular mechanics and organelle #mechanobiology" in Barcelona, Spain, 16–20 Feb 2026! Registration Deadline (in person/virtual): 15 Dec 2025/1 Feb 2026 Abstract Submission Deadline: 14 Nov 2025 meetings.embo.org/event/26-org... #EMBOmechanobio #EMBOevents 🧪
- Reposted by Suliana ManleyEp. #3 of The Lemma Journal Club! www.patreon.com/posts/mitoch... Paper: "The biophysical mechanism of mitochondrial pearling" by G. Sturm, @kayleyhake.bsky.social, ... @amsikking.bsky.social ... @sulianamanley.bsky.social @jclandoni.bsky.social @wallaceucsf.bsky.social
- This was a delightful meeting, thank you @nynkedekkerlab.bsky.social, @achilleskap.bsky.social , & @lumicks.bsky.social . I had a great time meeting UK’s young single molecule enthusiasts, so many exciting posters!
- Better late then never: we hadn't yet send out a thank-you to the UK Bluesky single-molecule community, so here goes: THANKS to all who contributed to the UK SMBio 2025 -- we had a blast! 🙌🏼 Especially to @nynkedekkerlab.bsky.social & @achilleskap.bsky.social for co-organizing 🙏🏼!
- Interesting! Scientists outside of Europe looking to move to the EU or Switzerland can benefit from this funding opportunity, it includes up to an additional €2 million beyond the grant cap for setup costs.
- The ERC welcomes the offer of substantial additional budget from @ec.europa.eu for the development of a new ERC funding instrument offering larger, longer-term grants, as announced by President Ursula Von der Leyen at the Sorbonne this morning. 👉 europa.eu/!NTYTTV
- Our latest preprint www.biorxiv.org/content/10.1..., describes Willi Stepp’s project to make smart microscopy even gentler by doing event detection in phase contrast. We developed neural networks to detect mito-LD and mito-lysosome contacts, as well as mitochondrial pre-fission constrictions.
- A key insight was building temporal information and memory into the ANN architecture. A huge thanks to all, especially our ‘smart’ (in so many ways) partner @maweigert.bsky. We could now detect local depolarization following constriction, using commonly used (bleachy TMRE) fluorescent biosensors.
- Reposted by Suliana ManleyFollowing the great success of the 2024 event, @ox.ac.uk and LUMICKS proudly present the second UK-Ireland symposium focusing on single-molecule research! The abstract deadline, 7 March, is approaching fast. Secure a talk or poster by registering now > bit.ly/4gYPPpQ
- Rockin’ out at EMBO in situ with @lycasworks.bsky.social @jonasries.bsky.social Christian Zimmerli, Mark Bates 🤘🔬
- MBL Physiology is totally invigorating, it’s a joyful mixture of: frontier scientific discoveries, kick-a$$ microscopes, and lovely, brilliant, generous ppl. I can’t wait for the summer!
- The deadline to apply for the MBL Physiology course is fast approaching, January 27th! Consider applying to this amazing, life-changing research discovery experience in Woods Hole! www.mbl.edu/education/ad...
- This was an amazing collaboration, we had the luxury of years of great conversations with @wallaceucsf.bsky.social and his team, as well as our other @HFSP partners @anjbadri.bsky.social and Johan Paulsson. Thanks for telling the story here, Wallace!
- Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint, @gavsturm.bsky.social investigates how mitochondria transiently adopt a beads-on-a-string morphology www.biorxiv.org/content/10.1...
- Reposted by Suliana ManleyStoked to share TWO preprints on mitochondrial pearling! 🎉 We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024...), and @gavsturm.bsky.social et al. dissect the biophysics behind it (doi.org/10.1101/2024...). Details below! 🔬🧵🧪
- I’m ultra excited about our preprints on mitochondrial pearling. In two concurrent collaborative studies with @wallaceucsf.bsky.social, we investigated its consequences on mtDNA nucleoids (led by @jclandoni.bsky.social) & its biophysical causes (led by @gavsturm.bsky.social). Funders HFSP, ERC, SNSF
- Nucleoids are known to be regularly spaced along mitochondria, important for their inheritance and maintenance of the local proteome. We identified pearling, a Plateau-Rayleigh type instability described since the 1980s, to be responsible: t.ly/KKmGK. Collab with JLS lab @hhmijanelia.bsky.social
- But what triggers pearling, and how can we make sense of the distinct morphological changes that take place? We pinpoint several perturbations that differentially impact membrane tension, elasticity, or osmotic pressure, and present a unifying framework: t.ly/yTsPr Collab with Calico Labs.
- I’m excited to join this session organized by Assaf Zaritsky and Megan Driscoll for the "Beyond Pretty Pictures" subgroup. I’ll share our latest on Smart Microscopy and mitochondria. #cellbio2024 @ascbiology.bsky.social Sat. Dec. 14, 11:15am, Rm 30C plan.core-apps.com/ascbembo2024/e…
- Reposted by Suliana ManleyWe are so excited that @janfunkey.bsky.social has agreed to give the keynote seminar for @qiatcshl.bsky.social 2025 @cshlnews.bsky.social! 🔬🖥️ 🛤️ Applications due 1/31/2025. t.co/x87ngy34UC
