Alexandra Colin
CNRS researcher in the Cytomorpholab (Grenoble, France)
- Reposted by Alexandra ColinReally excited to share our new paper in @nature.com! We uncovered how a physical instability of the cytoplasm coupled with the cell cycle drives cytoplasmic partitioning in early embryos #zebrafish #drosophila. Read more in this🧵 www.nature.com/articles/s41... 🤩 @poldresden.bsky.social @mpi-cbg.de
- Reposted by Alexandra ColinHappy to highlight our collaborative work from our @ijmonod.bsky.social team with @destriano.bsky.social, B. Goyeau and M. Chabanon. Cytoplasmic crowding acts as a porous medium that hinders macromolecular diffusivity. Plus: a clever way to measure cell volume. www.pnas.org/doi/10.1073/...
- Reposted by Alexandra ColinA few seconds of eternity: From microscope to museum❣️ It was truly delightful to be part of this project, celebrating life as a continuous dance of creation, collapse, and renewal. 🔄 Kudos to @manuelthery.bsky.social @lblanchoin.bsky.social #cytomorpholab members, and @museeorsay.bsky.social
- Reposted by Alexandra ColinWe spend way too much time manually analyzing #microtubules 🔬 Together with Mario, Justus, Dominik, Felix & Erik we used synthetic data and foundation models to build a fully automated segmentation pipeline. #microscopy, #imageanalysis & #AI Check out our preprint: www.biorxiv.org/content/10.6...
- Reposted by Alexandra ColinMy lab is hiring a postdoc (ERC funded)! If you're interested, get in touch!
- Reposted by Alexandra Colin📣 #Job alert! Looking to establish your own independent research in cell biology, development or evo-devo? The @cnrs.fr is recruiting 7 scientists in that area of research. Here are updated unofficial guidelines. Reach out to members of the committee if you have questions c3n-cn.fr/section-24-w...
- Reposted by Alexandra ColinLe CNRS a proposé au Sénat des mesures fortes pour renforcer la place des femmes en science. Cette sous-représentation n’est pas une fatalité : elle résulte de biais, de stéréotypes, d’inégalités et de violences tout au long des parcours scolaires et professionnels.
- Reposted by Alexandra Colin#Communiqué 🗞️ En 2026, pour célébrer ses 40 ans, le @museeorsay.bsky.social devient un véritable théâtre du vivant. Deux soirées dans la Nef plongeront le public dans un spectacle immersif au coeur des dynamiques cellulaires donnant vie à l’architecture de la gare. 👉 www.cnrs.fr/fr/presse/un...
- Reposted by Alexandra Colin👉Excited to share our latest work @natmicrobiol.nature.com, revealing a decrease in cytoplasmic crowding during filamentous growth in the human fungal pathogen Candida albicans. Furthermore we found that inhibition of ribosome biogenesis can trigger filamentous growth in this pathogen rdcu.be/eT1Su
- Reposted by Alexandra Colin🚨 Je cherche des chercheur-ses de toutes disciplines pour un doc radio pour parler de leur sujet de recherche mais aussi de leur quotidien (une journée type au labo). Contrainte supplémentaire, le labo doit être hors de Paris. Plus d'infos : forms.gle/hw9wH2p5UH4A...
- Reposted by Alexandra ColinCells can hunt prey, solve mazes, and learn from past experience. Does this mean they can think, at some level? Find out more at our upcoming session on "Cell Behavior and Cognition" at the ASCB/EMBO #cellbio2025 meeting, Saturday 1-3 pm rm 115.
- Reposted by Alexandra Colin#RésultatScientifique 🔎 | Comment les filaments d'actine s'organisent à l'intérieur des cellules et des tissus vivants 🔬 @institutfresnel.bsky.social 🤝 @univ-amu.fr @centralemed.bsky.social @cnrs.fr 📍 @cnrs-dr12.bsky.social
- Reposted by Alexandra Colinis there a direct crosstalk between actin and vimentin intermediate filaments? Our work shows that vimentin promotes actin assembly by stabilizing ATP-subunits at the barbed end. Fantastic work done by @lilianpaty.bsky.social with @romet-jegou-lab.bsky.social www.biorxiv.org/content/10.1...
- Reposted by Alexandra Colin⚡Ready to grow and be inspired as a scientist? We’re looking for a *PhD student* to join our lab at @crg.eu in Barcelona and explore how cells self-organize, uncovering life’s inner design💡 We offer strong mentoring, cutting-edge science, and a vibrant international team🌍 Check the link below!
- Reposted by Alexandra ColinVery excited that my final postdoctoral work is now online in Cell @cellpress.bsky.social. www.sciencedirect.com/science/arti... Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.
- Reposted by Alexandra ColinLive on Oct 7, the MBoC 2025 Early Career Award Webinar (Part 1) runs 12–1 pm ET. > Keynote: Margaret Gardel (UChicago) > lightning talks from UCSF, UVM, ETH Zurich, Cambridge & Harvard > moderation by John Aitchison Free to attend → www.ascb.org/ascb-meeting... #ASCB #CellBiology
- Reposted by Alexandra Colin”Please inhibit responsibly: Natural and synthetic actin toxins as useful tools in cell biology” I had a lot of fun going down different actin inhibitor rabbit holes with @onishilab.bsky.social on this perspective! www.molbiolcell.org/doi/10.1091/... www.molbiolcell.org/cms/10.1091/...
- Reposted by Alexandra ColinWe’re organizing a conference at @ijmonod.bsky.social in Paris, January 2026, in memory of M.P. Sheetz — pioneer in cell mechanics and mechanobiology, co-discoverer of kinesin, and founder of @mbisg.bsky.social. Join us to explore his legacy. mikeinmemoriam.sciencesconf.org
- Reposted by Alexandra ColinAllocation of resources among multiple daughter cells. New study from Alison Wirshing, Daniel Lew and colleagues @mit.edu: rupress.org/jcb/article/... #Cytoskeleton #Development
- Reposted by Alexandra ColinNew short paper from our lab @currentbiology.bsky.social, in which we discover of a new mode of cell motility for choanoflagellates: flagellar gliding. www.cell.com/current-biol... - A 🧵
- Reposted by Alexandra ColinWhich city is the best for Cytoskeleton research? Dresden? Barcelona? Cambridge ? Noooo ... you all know its Paris, right? 😎 Registering to the annual meeting on Friday 14th of November is now open: pcd2025.sciencesconf.org Keynote speeches by @carter-lab.bsky.social and Verena Ruprecht !
- Reposted by Alexandra ColinA new #UExM probe for #Actin! Fun times thinking/developing/testing with @centriolelab.bsky.social & @lreymond.bsky.social ! Congrats to all ! If interested in #UExM, or #HAK-Actin, feel free to reach out ! Soon available at @spirochrome.com #Expansion #Microscopy #ProtistsOnSky
- Trouble imaging actin in ExM? Meet HAK-Actin, a probe for U-ExM, cryo-ExM & iU-ExM. Enables post-expansion labeling for max signal. www.biorxiv.org/content/10.1... Soon at @spirochrome.com Led by O.Mercey and @lreymond.bsky.social, in collab with @dudinlab.bsky.social and @marinelap.bsky.social
- Reposted by Alexandra Colin🌱✂️ How do plant cells decide where to divide? Our work shows that actin can override the geometric rules—guiding cells to divide in alternative orientations. #PlantScience #CellBiology #Arabidopsis @camilagoldy.bsky.social @rdplab.bsky.social www.biorxiv.org/content/10.1...
- Reposted by Alexandra ColinMicrotubules: the architect of muscles. Watch how microtubules transport mitochondria in proximity to energy consuming sarcomeres in muscles of flies and mice. @jeromeavellaneda.bsky.social @nunoluis.bsky.social @ibdm.bsky.social with @gomeslabo.bsky.social www.sciencedirect.com/science/arti...
- Reposted by Alexandra Colin#science 🧬 | Non, ce ne sont ni les slips de Superman, ni ceux de Walter White dans Breaking Bad. C’est une cellule ... et la même photographiée 36 fois. Sensation, adaptation, mémoire… la cellule est plus futée qu’on ne le croit 🤯. Pour en savoir plus 👉 youtu.be/dX4rDXLJAdI
- We have used many microwells to confine biochemical reactions in our recent studies. We wanted to share the protocol for preparing and characterizing microwells; this protocol is now published here : www.frontiersin.org/journals/cel... @manuelthery.bsky.social @lblanchoin.bsky.social
- We detail the equipment and protocol for microwell manufacture, as well as characterization and quality control.
- We also give examples of imaging and functionalization to study actin-related processes.
- Reposted by Alexandra Colin🔬 From JCB’s July issue (rupress.org/jcb/issue/22...): a PtK2 cell plated on a micropattern and injected with low doses of soluble actin (orange) and tubulin (blue) in order to generate speckles along the corresponding filaments. From @manuelthery.bsky.social group (rupress.org/jcb/article/...).
- Reposted by Alexandra Colinthis focused issue includes a great method by @alexandra-colin.bsky.social to make closed microwell in order to encapsulate your favorite reconstitution mix in compartments of controled size and shape. 🔴🟥🔻❤️
- Interested in reconstitution methods? Love cell biology? Check out the accepted manuscripts in our Research Topic on Reconstitution Methods in Cell Biology! We are still open for submissions so if you're writing something exciting this summer, send it here: www.frontiersin.org/research-top...
- Reposted by Alexandra ColinInterested in reconstitution methods? Love cell biology? Check out the accepted manuscripts in our Research Topic on Reconstitution Methods in Cell Biology! We are still open for submissions so if you're writing something exciting this summer, send it here: www.frontiersin.org/research-top...
- Reposted by Alexandra ColinWant to brush up your French? Check the summary of our work with @stefvass.bsky.social, “Plongée au cœur de l'endocytose axonale”, just out in the June issue of Médecine/Science! Open access here: www.medecinesciences.org/fr/articles/... And we got the cover 😎
- Reposted by Alexandra ColinCome and Join our Dpt in Beautiful #Geneva ! We are looking for a #Microscopy & #Image #Analysis expert to help all of us at the Dpt.
- Hello microscopy and imaging experts and enthusiasts! We are looking for a staff scientist to join us here in Geneva to work on microscopy and image analysis projects! See the link for the job announcement (in French and in English). Please apply and/or repost! jobs.unige.ch/www/wd_porta...
- Reposted by Alexandra ColinRegistration and abstract submission for the 2025 SFP Physics & Life days are now open! The meeting will be held on October 2-3 at the Institute Jacques Monod, Paris. Deadline: September 5. phys-life-2025.sciencesconf.org?lang=en @sfp-physique.bsky.social @ijmonod.bsky.social
- Reposted by Alexandra ColinOne of the most exciting discoveries from our lab so far is now online as a preprint! Read a story on how the ParMR and Min systems started to collaborate to create the CorMR cytoskeleton, which now controls cell shape in multicellular cyanobacteria: www.biorxiv.org/content/10.1...
- Reposted by Alexandra ColinJust out: we used SReD to measure the periodicity of spectrin rings along axons, finely capturing the effect of actin depolymerization. This and many more applications ➡️ www.nature.com/articles/s41... Another great collab with @henriqueslab.bsky.social, congrats @afonsomendes92.bsky.social et al 🙏
- 🔬👨💻📰 #SReD is out! Automated structural detection for #ImageJ & #FIJI, from nano to macro ✨🐘. No training data, no bias - texture analysis with GPU acceleration!⚡️ Brainchild of @afonsomendes92.bsky.social and adventure w @christlet.bsky.social lab + friends. Check: www.nature.com/articles/s41...
- Reposted by Alexandra ColinAML patient blasts exhibit polarization defects upon interaction with bone marrow stromal cells. www.embopress.org/doi/full/10.... Work by Manuel Thery @manuelthery.bsky.social @institut-leucemie.bsky.social and co-workers.
- Normal blood progenitors in the bone marrow polarise towards the stromal niche, but acute myeloid leukaemia (a form of BM cancer) cells do not 📷 @el-khansa.bsky.social et al @manuelthery.bsky.social Lab, @ @upcite.bsky.social in @emboreports.org ➡️ bpod.org.uk/archive/2025...
- Reposted by Alexandra ColinExciting news: our Board of Trustees has appointed @monicabettencourt.bsky.social as the CRG's new Director. Prof Bettencourt-Dias is expected to take up the post in 2026, replacing Dr. Luis Serrano, who will continue to maintain a research group at the institute. www.crg.eu/en/news/moni...
- Reposted by Alexandra ColinLes membres du Conseil scientifique de l'ENS-PSL partagent la vive inquiétude des personnels d'@universcience.bsky.social sur le devenir du @palaisdecouverte.bsky.social et s'associent à la pétition en cours. En savoir plus 👉 bit.pulse.ly/b1pitkbaaa
- Reposted by Alexandra Colin🚨 JOB ALERT 🚨 We're hiring a Research Assistant – no PhD needed! Join us to explore the molecular mechanisms of receptor sorting in endosomes. Experience in protein expression/purification, cloning & cell culture desired 🧫🔬 Apply now 👉 www.nature.com/naturecareer... #STEMCareers #ResearchJobs
- Reposted by Alexandra Colin🔬 Vous souhaitez en savoir plus sur les médaillés 2025 de CNRS Biologie ? 📅 Rendez-vous chaque jour pour découvrir deux portraits de nos lauréats : leur parcours, leurs travaux, leur passion pour la recherche ! ⤵️
- Reposted by Alexandra Colin[ #TalentsCNRS ]🥉 Simplifier pour mieux comprendre le vivant🔬 Au LPCV, @alexandra-colin.bsky.social étudie l’organisation du cytosquelette d’actine sur des systèmes biomimétiques. Ses recherches sur ces mécanismes clés de la cellule lui valent la médaille de bronze 2025 du @cnrs.fr 👏
- [#TalentsCNRS] 🎖 10 médailles pour la délégation Alpes du @cnrs.fr en 2025 ! 4 médailles de bronze 🥉 3 médailles de cristal 💎 3 médailles de cristal collectif 💎🤝 👏 Félicitations à ces talents qui font avancer la recherche ! Portraits à découvrir ici chaque jour dès demain👇🧵
- Reposted by Alexandra ColinThe 2025 @cnrs.fr medal are out! Bronze medals for early career researchers: congrats to Aurélie Tchoghandjian at our institute @inp-marseille.bsky.social, and to @alexandra-colin.bsky.social who was nominated by the Cell biology section 🎉
- Reposted by Alexandra Colin✨Thanks to amazing students @tobiaskletter.bsky.social, postdocs @biswashere.bsky.social & collaborators @vasilyzaburdaev.bsky.social & ALMF @embl.org ✨ 👉Cytoplasmic material properties control spindle architecture and scaling 👉 out today @natcellbio.nature.com rdcu.be/eqPr8
- Reposted by Alexandra Colin
How do dormant cells keep their proteostasis in check? @gzaffagnini.bsky.social & our PhD student Stephanie Rosswag take a deep dive in our featured review @cp-trendsbiochem.bsky.social Don’t miss it! - EB www.sciencedirect.com/science/arti... - Reposted by Alexandra ColinSave the date for the 3rd edition of the Physics & Life days, division of the French Physical Society, October 2-3 at the Institute Jacques Monod, Paris. More info coming soon! Co-organised with Silvia Grigolon & Morgan Chabanon. @sfp-physique.bsky.social @ijmonod.bsky.social
- Reposted by Alexandra ColinWe have two open Master’s internship projects for the 2025/2026 academic year in our lab! 🔬🧬 You can apply directly through the BIST website: mmres.bist.eu/research-pro... We’re looking forward to hearing from you! 👋 @crg.eu @prbb.org @upf.edu
- We wrote a review for the Biochemical Journal on the importance of using macroscopic reconstructions at the network level to better understand key issues related to the actin cytoskeleton: portlandpress.com/biochemj/art...
- Reposted by Alexandra ColinWhat if we could trap Lipid Droplets and control their dynamics in cells? Our latest work does just that, using Engineered Condensates to manipulate LD behavior. Exciting results by Chems Amari and the team! Great collab with @abdourachidthiam.bsky.social #Organelles #Condensates rdcu.be/emYpU
- Reposted by Alexandra Colin📸 Concours Photo SBCF 2025 – 3 prix de 250€ à gagner ! 🔬 Mettez en valeur vos plus belles images de biologie cellulaire. 📅 Deadline : 22 juin à 23h59 👉 shorturl.at/GmqQY #BiologieCellulaire #SBCF #ConcoursPhoto
- Reposted by Alexandra ColinUnlike eggs & mitotic cells, in adherent interphasic cells the centrosome is NOT positioned by a balance of forces along #microtubules, but by cell shape organization around the #centrosome: rupress.org/jcb/article/... @lblanchoin.bsky.social @manuelthery.bsky.social @gelinmatthieu.bsky.social
- Reposted by Alexandra ColinOur PhD student Louis Romette is optimizing long-term live-cell imaging. He just casually dropped this 65-hour movie of a growing neuron (div 3 to 6) with knocked-in actin 🔥🕶️ #realtimemicroscopy
