altmeyerlab
Genome integrity maintenance during cell cycle progression: This is what we care about, this is what we study. #GenomeStability #ReplicationStress #DNADamage #UZH #Science #AcademicSky
altmeyerlab.org
- Reposted by altmeyerlabExcited to share our new Nature study! 🧬 We (sidrituruci.bsky.social et al) discovered that CFAP20 helps clear stalled RNAPII, preventing harmful clashes with DNA replication machinery. This protects cells from R-loops and genome instability. Full paper: www.nature.com/articles/s41...
- Reposted by altmeyerlabOrganelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
- Organelles harbour pH gradients biorxiv.org/content/10.64898/20…
- Reposted by altmeyerlab📢 Telomere community: Registration and abstract submission are now open for the EMBO Workshop “Telomere function and maintenance in health and disease”, May 25–30, 2026, in Lazise, Italy 🇮🇹. Looking forward to an exciting meeting! Please re-post. meetings.embo.org/event/26-tel...
- Reposted by altmeyerlab🚨 Exciting news! Our latest study is out in Nature Communications! We reveal how specific BRCA2 mutations can hijack transcriptional programs—beyond their role in DNA repair. 🔗 rdcu.be/eT1R9 #CancerResearch #BRCA2 #Genomics
- Reposted by altmeyerlabWe are recruiting a tenure track professor in the broader area of molecular biology @zmbh.uni-heidelberg.de at Heidelberg University! www.nature.com/naturecareer... Please share and apply!
- Reposted by altmeyerlab‼️ Excited to share our new paper out now in @science.org ‼️ We describe a new tetrameric RAD51 paralog complex – XRCC3-RAD51C-RAD51D-XRCC2 – which caps the end of RAD51 filaments. Link: www.science.org/doi/epdf/10.... Thread ⬇️ (1/8)
- A comprehensive genetic catalog of human double-strand break repair | Science www.science.org/doi/10.1126/...
- Reposted by altmeyerlabThe world has lost its most powerful advocate for nature and hope. Yet many remain who will continue her legacy and I know she will continue to inspire generations more.
- Reposted by altmeyerlabCome and join us at the Barts Cancer Institute @qmbci.bsky.social ! Our medical school, part of Queen Mary University of London @qmulfmd.bsky.social is hiring 10 professors!! www.veredus.co.uk/job/job-747a/. Contact me for a chat if interested.
- Reposted by altmeyerlabThrilled that our work is now finally out in Nature Comms! rdcu.be/eG3vP We reveal cryo-EM structures of the MRN complex bound to DNA & TRF2 - showing how DNA breaks are sensed and regulated at telomeres. Fantastic work by first authors @yilanfan.bsky.social @filizkuybu.bsky.social & Hengjun!
- Reposted by altmeyerlabCongratulations to Dirk Görlich and Steven L. McKnight, 2025 #LaskerAward winners! - “for discoveries that exposed the structures and functions of low-complexity domains within protein sequences” 🧪 @mpi-nat.bsky.social #Lasker2025 #LaskerLaureate #structuralbiology #phaseseparation
- Reposted by altmeyerlabMy first post on bsky to share our latest research in @nature.com: “DNA2 enables growth by restricting recombination-restarted replication” - defines DNA2’s essential function & elucidates links with primordial dwarfism and cancer. Thanks to the lab, collaborators & @ukri.org @acmedsci.bsky.social
- Reposted by altmeyerlab📢Deadline extended! Our 2nd Spatial Genome Organisation Conference deadline has been extended to 25 Sep, dont miss out on joining our fantastic line up of speakers, alongside Karim, Matthias and Irene in what is set to be a fantastic meeting this October! #SGO25 Final slots ➡️https://bit.ly/3JJzYR4
- Reposted by altmeyerlab@efapostolou29.bsky.social @thecesarelab.bsky.social we're looking forward to your presentations at this fantastic meeting!
- Reposted by altmeyerlabJOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto. www.nature.com/naturecareer... Please repost!
- Reposted by altmeyerlabDeadline approaching for #SGO25 🗓 31 Oct – 03 Nov 2025 📍Riviera Maya, Mexico Poster & Reg deadline: 01 Sept 2025 Details & Reg: bit.ly/45Mmhtv $250 registration grants available! Email amy@fusion-conferences.com with your name, position & current research topic.
- Reposted by altmeyerlabAdvertisements for 2 tenure-track assistant professor positions at Vanderbilt School of Medicine Basic Sciences: www.nature.com/naturecareer... www.nature.com/naturecareer...
- Reposted by altmeyerlabAnother exciting research article from a member of the #RepliFate network! The Altmeyer lab identified the CNOT1-CCR4-NOT complex as a multi-level suppressor of the 53BP1-p53-p21 signaling axis. Check out their findings here: doi.org/10.1016/j.ce...
- New work from the lab: Identification of CNOT1-CCR4-NOT as a suppressor of 53BP1-p53-p21 signaling @cp-cellreports.bsky.social. Congratulations to first author Antonio Galarreta and to all co-authors. www.cell.com/cell-reports.... #Microscopy #RNAiScreen #Condensates
- Reposted by altmeyerlabOur new non-denaturing nanoscale 3D DNA tracing technology provides single-cell (and sister-chromatid specific!) readout of chromatin structure with 10kb genomic resolution - Check it out! www.nature.com/articles/s41... Congratulations to Kai and Oyvind!!
- Reposted by altmeyerlab📣 We are recruiting new group leaders in Innovative Biology! RNA biology Epigenetic regulation Cell cycle regulation Cancer, immunology Virology Application and information ⬇️ application.igmm.cnrs.fr @cnrsbiologie.bsky.social @cnrsoccitanieest.bsky.social @umontpellier.bsky.social
- Reposted by altmeyerlabNew @nature.com An ingenious way to track DNA replication patterns at the single-cell level that leads to cell heterogeneity and daughter cells that can potentially give rise to cancer www.nature.com/articles/s41...
- Reposted by altmeyerlab🔬Under the microscope: DNA damage tracked through cell generations🔬 It was a pleasure to write this #NewsAndViews with our PhD student Emma Reilly, online today @nature.com rdcu.be/em0qi @cruk-ci.bsky.social @spjacksongroup.bsky.social @yalepathology.bsky.social @yalecancer.bsky.social
- Sharing our latest work tracking DNA damage inheritance by Live+QIBC www.nature.com/articles/s41.... Huge congrats to @apanagopoulos.bsky.social, M. Stout and all co-authors for this tour de force! Beautifully summarized by @s-j-aitken.bsky.social & E. Reilly www.nature.com/articles/d41...
- Looking very much forward to the 2nd edition of the Fusion Conference on Spatial Genome Organisation #SGO25 @fusionconf.bsky.social @karimmekhail.bsky.social @chiololab.bsky.social. Early bird registration closes soon: June 2nd, 2025. Slots available for selected talks from abstracts: bit.ly/4492G6i
- Reposted by altmeyerlabIMBA is recruiting a Junior Group Leader! Are you interested in starting your own lab, pursuing curiosity-driven basic research in the life sciences? Apply by May 18: imba.science/beagroupleader #hiring #biology #research #groupleader #europe
- Reposted by altmeyerlabWe are excited to announce the details for this year’s #DGZ International Meeting, a very special one as we are celebrating 50 years of DGZ! Join us in October in Heidelberg, where the DGZ was founded in 1975. Check the speakers line-up etc. at the poster. Registration: shorturl.at/EHUzb #DGZ50
- Reposted by altmeyerlabWe’re excited to share our work where we investigated the mechanisms of chromosome motion by tracking all #chromosomes, mapping their interactions, and live cell karyotyping, using #AI based denoising, segmentation and registration, published in Nature Cell Biology. www.nature.com/articles/s41...
- Interested in these or related topics and looking for (or know somebody looking for) a PhD position? We have openings and an approaching application deadline @lifesciencezurich.bsky.social: www.lifescience-graduateschool.uzh.ch/en.html. Please repost. #PhDLife #LifeScience #Switzerland
- How are chromosome breaks repaired and how is their repair influenced and facilitated by nuclear and genome dynamics? Fantastic initiative and collaboration with @karimmekhail.bsky.social, @chiololab.bsky.social, and @lablegube.bsky.social. @natrevmcb.bsky.social Link to article: rdcu.be/edViW
- Reposted by altmeyerlab1/10 Excited to share our latest - the first whole-body map of both DNA methylation and 3D genome at single-cell resolution.
- Reposted by altmeyerlabOur new findings on how chromosomes get ready for cell division are now published in @cellpress.bsky.social! Congratulations, Kai, @andibrunner.bsky.social and everyone else involved! 🤩 www.sciencedirect.com/science/arti...
- Did you know that DNA must form overlapping loops to give rise to the well-known X-shape of chromosomes? 🧬🧪 New research from EMBL's Ellenberg Group provides new insights into the process of chromosome formation. @ellenberglab.bsky.social @andibrunner.bsky.social www.embl.org/news/science...
- Reposted by altmeyerlabCome start your lab in beautiful Strasbourg 🇫🇷 www.nature.com/naturecareer...
- Reposted by altmeyerlabThrilled to share our lab's first preprint, led by an exceptional PhD student Gita Chhetri and with the support of wonderful collaborators, we find that replisome function is rate-limited by strand-specific PCNA dynamics. Hope you will enjoy reading. www.biorxiv.org/content/10.1... Brief teaser:
- How are chromosome breaks repaired and how is their repair influenced and facilitated by nuclear and genome dynamics? Fantastic initiative and collaboration with @karimmekhail.bsky.social, @chiololab.bsky.social, and @lablegube.bsky.social. @natrevmcb.bsky.social Link to article: rdcu.be/edViW
- Reposted by altmeyerlabI put together a small guide on how to get started with Fiji. Please distribute to anyone who might benefit form this! zenodo.org/records/1477... #imageanalysis #fiji #imagej #training
- Reposted by altmeyerlabWe have an exciting opportunity for a new independent group leader with an interest in structural/molecular biology and machine learning to join our Division of Structural Studies at the @mrclmb.bsky.social! 🥳 Re-posts appreciated. www.nature.com/naturecareer...
- Reposted by altmeyerlabNew discovery from our #CDlab reported in Cell @cp-cell.bsky.social today: SMC motor proteins have a left-right ‘gearbox’ and can switch direction in DNA loop extrusion! www.sciencedirect.com/science/arti... 1/
- Reposted by altmeyerlab1/Delighted to announce the newest paper from our lab, “Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage”, is out today in @naturecellbiology.bsky.social, www.nature.com/articles/s41....
- Reposted by altmeyerlabMark your calendar: the next Egmond DNA repair meeting will take place in 2026 from April 19 - 24! You can pre-register to receive announcement here: forms.lumc.nl/lumc2/Egmond Registration will open by June 2025/
- Reposted by altmeyerlabwww.academics.com/jobs/univers... Please help us find a new colleague at Mainz University. Thanks! #evolbiol
- Reposted by altmeyerlab🧪1/ 🚨New paper on ecDNAs from our lab! We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇 www.nature.com/articles/s41...
- Reposted by altmeyerlab@mrc-lms.bsky.social is hiring! Are you looking to start your own research group? Come & join us! Fantastic research, wonderful facilities & super supportive colleagues. Deadline 13th Jan. Get on it! lms.mrc.ac.uk/work/vacanci...
- Reposted by altmeyerlab📣 Please share: We’re hiring a tenure-track Group Leader in Multicellular Systems to explore the molecular and cellular mechanisms driving the formation, maintenance, or destabilization of tissues, organs and organisms. Apply at: www.fmi.ch/education-ca...
- Reposted by altmeyerlabI guess I told you about the fact that SMC proteins like cohesin and condensin are a novel class of molecular motors that make loops into DNA (something we visualized first in 2018). These DNA loops are the fundamental motif that organize our chromosomes. 0/
- Reposted by altmeyerlab
- Reposted by altmeyerlabAnd since we're here... 🥼 Join us as a Group Leader in #ComputationalBiology or #RNA Biology 🧬 More details via www.imb.de/jobs Application deadline is 5 January 2025 #sciencejobs #resilience #biostatistics
- Reposted by altmeyerlabi might be biased, but this place is amazing: great colleagues, vibrant campus, brilliant students/postdocs - and Vienna! perfect for starting an ambitious project. apply now for a GL position at the IMP … www.imp.ac.at/career/open-...
- Reposted by altmeyerlabMy first post on Blue Sky - moving over ! For all post-docs out there - fantastic opportunity @EMBL. Independent group leader position: Core funding, state-of-the-art core facilities, access to fantastic Ph.D. students, and of course amazing colleagues. Please apply www.embl.org/jobs/positio...
