The West Lab @ The Crick
The West Lab @TheCrick studies mechanisms of DNA Recombination and Repair. Tweets by lab members, unless signed SCW. Views are own.
crick.ac.uk/research/labs/steph…
- Reposted by The West Lab @ The CrickI am happy to share that my postdoctoral work in the @gerlichlab.bsky.social at @imbavienna.bsky.social is finally out 🎉! Our study reveals how cohesin guides focused and accurate homology search. Read more 👉 www.science.org/doi/10.1126/... Follow along for key insights and updates! 🧵
- Reposted by The West Lab @ The CrickThrilled to share that my postdoc research is published today in @science.org! We found that DNA repair uses cohesin complexes to build new chromatin loops that guide the homology search and boost accurate repair! 1/n www.science.org/doi/10.1126/...
- Reposted by The West Lab @ The CrickI’m very happy to share Zhong Han’s beautiful work on the biochemical function of Senataxin, encoded by a gene that is mutated in rare and early-disabling neurodegenerative diseases. Turns out it rescues backtracked RNA polymerase II during early transcription! www.sciencedirect.com/science/arti...
- ‼️ Excited to share our new paper out now in @science.org ‼️ We describe a new tetrameric RAD51 paralog complex – XRCC3-RAD51C-RAD51D-XRCC2 – which caps the end of RAD51 filaments. Link: www.science.org/doi/epdf/10.... Thread ⬇️ (1/8)
- Homologous recombination repairs DNA double-strand breaks via the RAD51 filament, which searches for homology and drives strand exchange. BRCA2 and the RAD51 paralogs (RAD51B, RAD51C, RAD51D, XRCC2, XRCC3) promote filament assembly; however, their mutation causes cancer and Fanconi anaemia. (2/8)
- New review out on molecular glues: turning serendipitous hits into smartly designed drugs that tag cancer-linked proteins for destruction 🧬💥💊 www.tandfonline.com/doi/full/10....
- Reposted by The West Lab @ The CrickPostdoc positions open in my lab (Francis Crick Institute) to study 1. initiation of DNA replication. 2. chromatin replication/epigenetic inheritance. Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists. Deadline 3 August 2025. crick.wd3.myworkdayjobs.com/External/job...
- A photo from the recombination mechanisms conference in Crete last week. Thanks to the @fusionconf.bsky.social team, speakers, poster presenters and attendees for a great meeting!
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