Fromme Lab
We study how cells sort important stuff around their insides and to their outsides - Cornell University in beautiful Ithaca, NY
https://fromme.wicmb.cornell.edu
- Reposted by Fromme Lab[Not loaded yet]
- Reposted by Fromme LabWeill Institute is recruiting postdocs, please share! Fischer Lab: lnkd.in/eMnveqyv Hu Lab: lnkd.in/epsGK7wd
- Calling all GTPase enthusiasts! The 2026 Regulation and Function of Small GTPases FASEB conference will be held June 22-24 in Florida, USA. events.faseb.org/event/Small-...
- So in awe of our neighbors, another important study from the Baskin lab using such powerfully clever and elegant tools. Feeding-Fishing for the win!
- Thrilled to share our latest study, led by @reikatei.bsky.social, in @natchembio.nature.com! We began by asking a simple question—how do cells know if they have too much of a lipid in a particular membrane, and how do they respond to rectify this imbalance? www.nature.com/articles/s41... More info 👇
- Awesome opportunity!
- We are so happy that @tarafisch.bsky.social has joined us at Cornell !!!
- We are absolutely THRILLED to welcome our newest faculty member @tarafisch.bsky.social to the @weillinstitute.bsky.social community. We look forward to the exciting and impactful work ahead! news.cornell.edu/stories/2026...
- Reposted by Fromme LabWe are absolutely THRILLED to welcome our newest faculty member @tarafisch.bsky.social to the @weillinstitute.bsky.social community. We look forward to the exciting and impactful work ahead! news.cornell.edu/stories/2026...
- Excited to start 2026 out with a new manuscript from our lab, please check out this thread from superstar postdoc @rvig.bsky.social about how he discovered the function of a conserved secretory protein, and how this also led him to the identification of a new family of GAP proteins!
- Mind the GAP 🚧🕳️🚧 Excited to share the latest preprint from the Fromme Lab (@fromme-lab.bsky.social), showing that the DENN domain protein Avl9 functions as an Arf-GAP, revising long-standing assumptions about DENN protein function, 🧵: www.biorxiv.org/content/10.6...
- Reposted by Fromme LabCheck out our new biosensor technology to study DDR kinase signaling: ProKAS. We combine: -proteomics -engineered peptide sensors -a new concept of amino acid barcodes ProKAS tracks kinase signaling with spatial resolution and produces highly quantitative data. Just published today: rdcu.be/ePNo0
- Sarah and the Cohen lab are doing amazing work!!!
- Ithaca is gorge-ous! Thank you @fromme-lab.bsky.social, @jeremybaskin.bsky.social and colleagues for a very fun and stimulating visit to the Weill Institute for Cell and Molecular Biology at Cornell!
- Reposted by Fromme Lab
- Reposted by Fromme Lab🎉 Huge congrats to Maya Schuldiner from the Weizmann Institute (Israel) for the 🏅 Otto Warburg Medal 2026! Her work on how proteins find their way to organelles and how these organelles talk to each other has reshaped how we think about cells 🧬✨ #OWM #WeizmannInstitute @elsevierconnect.bsky.social
- Reposted by Fromme Lab[Not loaded yet]
- Reposted by Fromme Lab[Not loaded yet]
- Reposted by Fromme Lab[Not loaded yet]
- Reposted by Fromme LabAttention membrane traffickers! I'm recruiting a post-doc to my lab in Dundee. We're dissecting the functions of intrinsically disordered domains of COPII coat proteins. We think they control timing of coat assembly and morphology of carriers. www.dundee.ac.uk/work-for-us/...
- Reposted by Fromme LabA while back we found that the lipid-binding protein PLEKHA4 boosts Wnt/β-catenin signaling and drives melanoma growth in vivo. Now, we (Nathan Frederick) identify small-molecule inhibitors of PLEKHA4 & related proteins with anticancer activity in vitro! pubs.acs.org/doi/10.1021/....
- Reposted by Fromme LabThe mechanistic basis of cargo selection during Golgi maturation. From Rebecca Taylor, @katciazynska.bsky.social, @jggkaufman.bsky.social & @grigorytagiltsev.bsky.social at @mpibiochem.bsky.social with David Owen and Sean Munro's group @cellbiol-mrclmb.bsky.social | www.science.org/doi/10.1126/...
- Reposted by Fromme LabHow do cells sense & respond to lipid imbalances? What happens when a disease-relevant enzyme is blocked? Shiying Huang investigates phosphoinositide lipids with the Balla lab & discovers an integrated cellular response that boosts alternate lipid synthesis pathways! www.biorxiv.org/content/10.1...
- Reposted by Fromme Lab[Not loaded yet]
- Reposted by Fromme LabLatest endosomal publication with @brettcollins.bsky.social: Rebeka Butkovic's beautiful work identifying a new Commander assembly, the RAB32-LRMDA-Commander, and its role in melanosome biogenesis. Reveals molecular mechanism of human oculocutaneous albinism type 7. www.nature.com/articles/s41...
- We are hiring, come be our colleague! jobs.sciencecareers.org/job/675236/t...
- Reposted by Fromme Lab[Not loaded yet]
- Reposted by Fromme Lab@weillinstitute.bsky.social first Trainee Works in Progress Seminar of the fall semester with Mingqin Chang of @fromme-lab.bsky.social
- Reposted by Fromme Lab[Not loaded yet]
- Reposted by Fromme LabWonderful to see our paper on the #organelle signatures of #neurons and #astrocytes out in final form - congratulations, Shannon Rhoads and team!🎉 t.co/BPxKlbU6Ou
- Reposted by Fromme LabDylan's study is now out in @jacs.acspublications.org! Key new experiments by Yuan-Ting Cho support a model for why a rare three-tailed lipid, NAPE, might accumulate during stroke & heart attack: as a protective response to promote lactate export as cells shift to glycolysis doi.org/10.1021/jacs...
- Reposted by Fromme LabThrilled to share our newest publication in Science Advances! We uncovered how two RabGEF complexes — Mon1-Ccz1 and Fuzzy-Inturned — adapt to regulate distinct Rab GTPases despite their structurally conserved catalytic core. www.science.org/doi/full/10....
- Reposted by Fromme LabNew research from @roederlab.bsky.social: Plant cell wall mechanics inform how to grow usable forms news.cornell.edu/stories/2025...
- Reposted by Fromme Lab[Not loaded yet]
- Reposted by Fromme LabVery excited to announce that my first, first author paper, is now on BioRxiv! In this paper we unambiguously show #COPII coated vesicles in unperturbed human cells for the very first time!! Make my day and check it out! www.biorxiv.org/content/10.1... #Cryo-ET #TeamTomo #Cryo-CLEM ❄️🔬❄️🔬❄️🔬❄️🔬
- Wow! GOLPH3 binding to COPI is competitive with binding of canonical -KKXX cargos, providing an elegant mechanism for differential sorting of COPI cargos during Golgi maturation. Congratulations to all the authors on an impressive and important study: www.biorxiv.org/content/10.1...
- Our neighbors are the best!!!
- Reposted by Fromme Lab[Not loaded yet]
- Reposted by Fromme LabHappy #GolgiDay to all who celebrate!! Made a Golgi “stack” to celebrate 😉🥞 (featuring my beloved and elusive Golgi tubules..!)
- Bryce Brownfield's review on the structural biology of Golgi trafficking has been published! authors.elsevier.com/a/1kqrY3PA3s... Bryce is now a postdoc in the @buzbarstow.bsky.social lab, we miss him dearly!
- Crazy how sharing a new paper at this moment feels insignificant in relation to all that is happening, but also feels important to keep doing our jobs and be proud of the work we all do
- Reposted by Fromme LabIt’s an honor to receive the ACS Chem Biol Young Investigator Award! I’m most grateful for the contributions from all past & present lab members — it is an award for all of you as much as for me. (& also grateful to still be considered young 😅) axial.acs.org/chemical-bio... @acsbiol.bsky.social 1/2
- Reposted by Fromme Lab12. Like art, music, philosophy, and literature, science is literally part of humanity's heritage. My colleagues and I have had the amazing opportunity to be part of something vastly larger than ourselves, with meaning that transcends any state, regime, or generation. They can't take that away.
- Reposted by Fromme Lab[Not loaded yet]
- Reposted by Fromme LabApplications are open for the Weill Institute Emerging Scholars Symposium @ Cornell! Senior PhD students and, now, postdocs interested in networking & presenting their work in cell & molecular biology should apply by April 14, 2025. Please repost! wicmb.cornell.edu/emerging-sch...
- Reposted by Fromme Lab[Not loaded yet]
- Reposted by Fromme Lab[Not loaded yet]
- Reposted by Fromme Lab[Not loaded yet]
- Reposted by Fromme LabIn this new paper we find that Tel1 kinase (yeast ATM) targets D/E-S/T motifs… more prevalent than S/T-Q! Mec1 (yeast ATR) can’t target D/E-S/T, so we think D/E-S/T targeting allows Tel1 functional specialization. A mutation in Tel1 makes it only target S/T-Q… and cells become CPT sensitive.
- Reposted by Fromme LabExcited to share our preprint reporting a completely new approach to study kinase signaling: ProKAS. ProKAS is based on a tandem array of peptide sensors with barcodes for multiplexed, spatial and kinetic applications. We applied it to DDR kinases. Please share. www.biorxiv.org/content/10.1...
- Reposted by Fromme LabOur paper about the development of programmable antigen-gated G-protein-coupled engineered receptors (PAGERs) is published today! www.nature.com/articles/s41... PAGERs couple detection of a wide range of custom-defined antigen to a variety of output including transgene expression and cell signaling.
- Excited to share the published version of our work by @ryanfeathers.bsky.social and @rvig.bsky.social on the structural basis for activation of Rab6 by the Ric1-Rgp1 complex! rdcu.be/d2mu3 Here is an updated thread about the paper we first shared on that older platform when we posted the preprint
- Rab6 is a central regulator of the Golgi, important for trafficking and autophagy. Rab6 is activated by its GEF, the Ric1-Rgp1 complex, but it was unknown how this complex performs nucleotide exchange to activate Rab6. (2/10)
- @ryanfeathers.bsky.social used #cryoEM to determine the structural basis of the Rab6 activation process. Ryan’s structure reveals the architecture of the complex and provides a mechanistic explanation for Ric1-Rgp1 function. (3/10)
-
View full thread@rvig.bsky.social contributed important experiments, including analysis of the Rab6 HVD, after @ryanfeathers.bsky.social moved to Princeton for his postdoc in the Zhong and Hughson labs. We are grateful for help from @cryomariena.bsky.social and @katiespoth.bsky.social with data collection. (10/10)
