Smolka Lab
Signaling mechanisms in genome biology: DNA repair, DNA replication and the cell cycle. Proteomic tools for exploring kinases and phosphatases.
Cornell University, Ithaca - https://smolka.wicmb.cornell.edu
- Check out our new biosensor technology to study DDR kinase signaling: ProKAS. We combine: -proteomics -engineered peptide sensors -a new concept of amino acid barcodes ProKAS tracks kinase signaling with spatial resolution and produces highly quantitative data. Just published today: rdcu.be/ePNo0
- And a nice Cornell Chronicle article about it: New biosensor technology maps enzyme mystery inside cells news.cornell.edu/stories/2025...
- A significant conceptual advance in the field of DNA recombination… great work by the labs of @brookscrickard1.bsky.social and Michelle Wang
- Just throwing this out there as a significant conceptual advance in the field www.biorxiv.org/content/10.1...
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- Reposted by Smolka LabWe are counting down the days to our Protein Science Symposium on June 10-12! Thrilled to be hosting our colleagues from WCM @weillcornell.bsky.social as well as keynote speakers Dr. Christopher Lima @christopherdlima.bsky.social and Dr. Jin Zhang @jinzhanglab.bsky.social
- New preprint from the lab: ATM controls fork processing and restart, and the PPM1D phosphatase is needed to properly balance this action of ATM. Congratulations to @yitingcao.bsky.social @yingzhengwang.bsky.social and Jumana Badar. www.biorxiv.org/content/10.1...
- Double award to the fantastic graduate student @mateuszwagner.bsky.social …
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- Reposted by Smolka LabApplications are open for the Weill Institute Emerging Scholars Symposium @ Cornell! Senior PhD students and, now, postdocs interested in networking & presenting their work in cell & molecular biology should apply by April 14, 2025. Please repost! wicmb.cornell.edu/emerging-sch...
- Senior graduate students and postdocs, here is a great opportunity to network, showcase your science and get to know Cornell and beautiful Ithaca! Please repost.
- Reposted by Smolka LabMy first-author paper on uncovering a non-canonical Tel1 motif using phosphoproteomics has been published in JBC! Amazing to work with @rainshj.bsky.social using both untargeted and targeted mass spectrometry. Check it out: doi.org/10.1016/j.jb...
- Very interesting work by the @zhalab.bsky.social showing why Ku is essential in human cells
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- In this new paper we find that Tel1 kinase (yeast ATM) targets D/E-S/T motifs… more prevalent than S/T-Q! Mec1 (yeast ATR) can’t target D/E-S/T, so we think D/E-S/T targeting allows Tel1 functional specialization. A mutation in Tel1 makes it only target S/T-Q… and cells become CPT sensitive.
- Great work by graduate students Will Comstock (@wjcomstock.bsky.social) and Shrijan Bhattarai (@rainshj.bsky.social)
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- Excited to share our preprint reporting a completely new approach to study kinase signaling: ProKAS. ProKAS is based on a tandem array of peptide sensors with barcodes for multiplexed, spatial and kinetic applications. We applied it to DDR kinases. Please share. www.biorxiv.org/content/10.1...
