New preprint from the lab:
ATM controls fork processing and restart, and the PPM1D phosphatase is needed to properly balance this action of ATM.
Congratulations to
@yitingcao.bsky.social @yingzhengwang.bsky.social and Jumana Badar.
www.biorxiv.org/content/10.1...
An ATM-PPM1D Circuit Controls the Processing and Restart of DNA Replication Forks
In response to DNA replication stress, DNA damage signaling kinases inhibit origin firing and promote the remodeling and stabilization of replication forks, leading to a systemic reduction in DNA synt...
