Silas Maniatis
Father and scientist. Doing dad stuff in Brooklyn and science at New York Genome Center.
𝘈𝘴𝘴𝘰𝘤𝘪𝘢𝘵𝘦 𝘋𝘪𝘳𝘦𝘤𝘵𝘰𝘳, 𝘚𝘱𝘢𝘵𝘪𝘢𝘭 𝘎𝘦𝘯𝘰𝘮𝘪𝘤𝘴
𝘈𝘳𝘤𝘩𝘪𝘷𝘦 𝘰𝘧 𝘮𝘺 𝘵𝘪𝘮𝘦 𝘢𝘵 𝘵𝘩𝘦 𝘰𝘭𝘥 𝘱𝘭𝘢𝘤𝘦 @𝘮𝘢𝘯𝘪𝘮𝘰𝘵𝘢𝘴𝘰𝘭𝘥𝘴𝘵𝘶𝘧𝘧.𝘣𝘴𝘬𝘺.𝘴𝘰𝘤𝘪𝘢𝘭
@𝘮𝘢𝘯𝘪𝘮𝘰𝘵𝘢 𝘰𝘯 𝘮𝘰𝘴𝘵 𝘱𝘭𝘢𝘵𝘧𝘰𝘳𝘮𝘴
- Reposted by Silas Maniatis"It may take time to prove you're right, but you have to stick to it." - Fred Korematsu Jailed for refusing to abide by FDR's Exec Order 9066, he took his case against internment all the way to the Supreme Court - and lost. Remember him on Korematsu Day, January 30th. 1/
- Reposted by Silas Maniatis[Not loaded yet]
- Just called both of my senators @schumer.senate.gov and @kirstengillibrand.bsky.social to let them know that appropriations for DHS are not compatible with a free society and that personnel shuffles do not matter. Even if my federal funding ends as a result, DHS must go and Holman Bondi et al too
- Reposted by Silas Maniatis[Not loaded yet]
- Reposted by Silas ManiatisThis is the most astonishing graph of what the Trump regime has done to US science. They have destroyed the federal science workforce across the board. The negative impacts on Americans will be felt for generations, and the US might never be the same again. www.nature.com/immersive/d4...
- Seems like voluntarily installing a secret police surveillance node at one’s own expense might be an action that one’s neighbors find upsetting. Would be weird and totally unrelated if all of a sudden lots of these went missing, or had sensors damaged with lasers etc techcrunch.com/2025/10/16/a...
- Reposted by Silas ManiatisI’m one of the ProPublica reporters who has been documenting the aggressive tactics federal agents are using against immigrants & U.S. citizens All eyes are on Minnesota right now, but I want to tell you about Arnoldo Bazan, a 16-YO citizen in Houston who was choked by immigration agents in October
- Reposted by Silas Maniatis3 papers in Cell @cellpress.bsky.social today exploring the mechanistic connection between Epstein-Barr virus and multiple sclerosis #MultipleSclerosis cell.com/cell/fulltex... cell.com/cell/fulltex... www.cell.com/cell/fulltex...
- TDP43 dysfunction in ALS leads to transposon mayhem in the transcriptome. Nice work from @nygenome.org ‘s ALS consortium, lead by Hemali Phatnani, and @nyulangone.bsky.social ‘s @karthiknatarajan.bsky.social & @mollygale.bsky.social. Nice work guys! www.biorxiv.org/content/10.6...
- Reposted by Silas Maniatis“Analysis of Biological Data with Python” started today for biology bachelor students 🧬🐍 Want to learn Python for data analysis? Slides are freely available: github.com/bpucker/teac... #Python #DataAnalysis #Biology #OpenScience #BigData #Bioinformatics #DataScience @puckerlab.bsky.social
- Reposted by Silas ManiatisNew York City turned OUT. @handsoffnyc.bsky.social ✊❤️
- Reposted by Silas ManiatisNever forget. 🇺🇸
- Reposted by Silas ManiatisZohran just went out and fixed the Williamsburg Bridge bike entrance. Just did it. No faffing, no nonsense. Bam. Fixed.
- Reposted by Silas Maniatis[Not loaded yet]
- Reposted by Silas Maniatis[Not loaded yet]
- Reposted by Silas Maniatis20-plex volumetric super-resolution imaging of cellular ultrastructure. Preprint, led by @seweryn-galecki.bsky.social, dropping soon.
- Reposted by Silas ManiatisI was wondering what Mamdani's first executive order would be, and I'm not disappointed by this. He has wiped off the books EVERY Eric Adams executive order issued on or after September 26, 2024, the day Adams was indicted on federal bribery charges.
- It’s been amazing to watch the growth of the biomedical industry in NYC over the past decade. It’s also terrible watching it be destroyed by federal actions. To remain competitive with respect to national and global centers of biomedical research and industry, NY state must step in and invest!
- 📢 SIGN & SHARE THE PETITION! 📢 New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW
- Reposted by Silas ManiatisStill my favorite 3D reconstruction of a pancreatic tissue. Using the CODA workflow, we mapped a billion individual cells in 3D. Red: pre-cancer lesions Navy blue: ducts Light blue: islets of Langerhans Purple: acini Green: blood vessels Yellow: fat More here: www.nature.com/articles/s41...
- Reposted by Silas Maniatis[Not loaded yet]
- Reposted by Silas ManiatisNEW: The first two years of Massachusetts' millionaire tax has raised $3 billion more than expected. And rather than driving the rich away, IPS researchers found that the number of millionaires has *increased.* Tax the rich. Greg Ryan in @bloomberg.com:
- If they send the money out $2k at a time to 100s of millions of people, it will be that much harder for the Supreme Court to rule the tariffs unconstitutional because it would be impossible to claw the money back. So heads trump is emperor, tails there’s no consequences when he does illegal stuff.
- Saturday 11/9/25
- Reposted by Silas Maniatis[Not loaded yet]
- Reposted by Silas Maniatis[Not loaded yet]
- One of my favorite things about the Mamdani sign style meme is how few people posting them have any interaction with the fact they are clearly a callback to NYCHA signage.
- Reposted by Silas Maniatis[Not loaded yet]
- Reposted by Silas Maniatis[Not loaded yet]
- Reposted by Silas Maniatis[Not loaded yet]
- Reposted by Silas Maniatis[Not loaded yet]
- Just hit 4K miles on the family cargo bike while taking the kids to school this am. This thing has been one of the biggest parental level-ups we’ve discovered. It’s made the commute something the kids look forward to, and has cut my commute (which was not bad to start) in half.
- Reposted by Silas Maniatis"HOW WILL ZOHRAN PAY FOR FREE BUSES" screamed the Staten Islanders who have a free ferry
- Reposted by Silas ManiatisNOAA’s National Weather Service holds the federal responsibility for tsunami warnings, and has historically been a primary supporter of seismic data collection in Alaska
- I’m @manimota .. Dodgers second only to the Sox for me. Ohtani is maybe the greatest player in my lifetime… Rooting for Canada right now
- Reposted by Silas Maniatis[Not loaded yet]
- Just FYI, @thelotradio.com has a community fridge and great music. If you’re in North Brooklyn, please consider donating there, or to any other food bank (North Brooklyn Angels is another good one). 1/8 of us are about to lose vital nutritional support. If you have the means, help your neighbors
- Reposted by Silas ManiatisGovernor Kathy Hochul is speaking on stage, but the crowd keeps interrupting to chant #TaxTheRich @zohrankmamdani.bsky.social
- I mean, dude has a pied-a-terre here I guess, but snuggles with his leaded gas era Camaro upstate most nights.. anyway…. If there’s an honest debate over progressive local taxation though.. Check out what happened in Boston when they put in a wealth tax. (Hint. The billionaires didn’t move)
- Reposted by Silas Maniatis💡Just presented our new paper at the @iccv.bsky.social BioImage Computing workshop: cubic: CUDA-accelerated 3D Bioimage Computing. We introduce a simple way to add GPU acceleration to scikit-image–based bioimage processing pipelines by swapping import statements. 🧵 1/6 #iccv2025
- Reposted by Silas ManiatisThe New England Journal of Medicine and the Center for Infectious Disease Research and Policy will be publishing regular public health alerts to replace the CDC’s Morbidity and Mortality Weekly Report, which has been paused due to the federal government shutdown.
- www.instagram.com/amnewyork/re... down the street from NYGC today
- Reposted by Silas Maniatis[Not loaded yet]
- Dep_H_Sec had a big raid on canal near the genome center today. Came home and took kids to the park and immediately saw Coast_G (part of same org) deploying drones on the east river.
- Remember when the U.S. was like ‘there’s this new technology that will give us a fundamentally new understanding of something important.. it will cost us a ton of money to figure this out, but let’s do it to prove we’re the best, and because it will make some US company a ton of money!’ Yeah….
- Reposted by Silas Maniatis🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution. www.biorxiv.org/cgi/content/...
- That surprise being the proposal to eliminate all nuclear weapons… To which Reagan said, nah, we’re good. SDI (AKA Star Wars, space based defense against nuclear missiles) is more important.. What a tragedy for the world to have a demented old racist at the helm at a critical moment
- So what’s the plan if there’s a biological weapon used against the United States? We have no CDC as of last night, so we probably wouldn’t even know until hospitals are so overwhelmed that there’s no way to deny it. Even then, we’ll have no way to know if it’s a weapon or to mount a defense.
- Reposted by Silas Maniatis[Not loaded yet]
- All of a sudden getting lots of inflammatory memeish divisive content pushed to my discover and popular with friends feeds here. Very reminiscent of 2016. Please be cognizant of what is being put in front of you
- Environs of NYGC when I moved to NYC. fun fact: those jnko and UFO ‘parachute pants’ started as a style in the NYC junglist scene after my buddy Alex ‘Lex Luger’ Dawson picked up a pair of surplus FRG paratrooper pants from the surplus store w the mortar in 1996 www.instagram.com/90snycity/re...
- Watson said she saw agents dragging residents, including kids, out of the building without any clothes on and into U-Haul vans. Kids were separated from their mothers, she said. “It was heartbreaking to watch,” said Watson, “it was horrible.” chicago.suntimes.com/immigration/...
- Thank you Dr Goodall for teaching us that non-humans can be sentient, that non-humans make tools, and that deep empathy with a being so different from one’s self is the path to wisdom. But most importantly, thank you for inspiring my daughter and for inspiring me. youtu.be/X-i9kV2Htuc?...
- Reposted by Silas ManiatisNEWS: The federal govt is sending NYC’s top disease control official to Arizona for a months-long stint at an Indian Health Service facility. That could complicate local infectious disease response efforts. “If we have an outbreak, then we’re fucked,” a city health department staffer told me.
- Reposted by Silas ManiatisThe South Korean Ministry of Defense has awarded medals of merit to 11 officers for disobeying direct orders of superiors during the martial law fiasco, orders that they deemed to be contrary to the constitution and endangerment to democracy. www.chosun.com/english/nati...
- Just a reminder that the plan always was to fire federal workers until every agency’s staffing is at the same level as during a shutdown. They put it in the original DOGE EO. So, please remind your representatives of this when they get worried about firings instead of furloughs.
- Reposted by Silas Maniatis[Not loaded yet]
- Thinking about and sending good will to all H1B holders abroad at meetings or visiting home etc, scrambling to make it back to the U.S. in the next 2hrs45min. This is unbelievably cruel and self destructive. H1B visa holders are the backbone of US dominance in science, engineering, & tech.
- Reposted by Silas Maniatis[Not loaded yet]
- What the hell? @npr.org is right now platforming Curtis Yarvin on its show ‘open to debate’. The topic of debate: would the U.S. be better off as a dictatorship? This is insanely dangerous and stupid. We fought several wars, including our foundational war, that already answered this ‘question’
- I’m returning from being on a panel at a conference in San Diego, and TSA is at the gate questioning everyone boarding the plane and checking IDs. I’ve never seen this before. They just questioned 4 active duty military personnel as they boarded
- As I fall asleep 24 years later, I know I will never again smell a structure fire without being instantly transported back to that day and the month of smoke that followed. Fuck all of these narcissistic performative little men. And I mean all of them. In every place & for any ‘cause’ they claim.
- Brooklyn golden hour remains undefeated
- Reposted by Silas Maniatis[Not loaded yet]
- Reposted by Silas Maniatis[Not loaded yet]
- Reposted by Silas ManiatisAs national medical, scientific, public health and patient organizations, we call for the resignation of HHS Secretary Robert F. Kennedy Jr. to ensure the health of the American people. Read our statement: asm.org/press-releas...
- Reposted by Silas ManiatisThis was a wonderful project to work on! It also, in part, sparked a lot! Beyond just our handles: @trackingskills.bsky.social aka trackingplumes (Bluesky and X), when I wanted to track mouse hands & Alex noses, we teamed up in 2017 to make @deeplabcut.bsky.social 💜 Delighted to see this out! 🙏🏼
- Thrilled to share this work, long time in the making! Carried through creatively by @siddjakes.bsky.social after initial design & piloting by @trackingskills.bsky.social, with help from @trackingactions.bsky.social. Modeling in collaboration with Massimo Vergassola & Nicola Rigolli.
- Always great to see nice work by good friends published! Congrats Olena, Hemali, and Neil! www.sciencedirect.com/science/arti...
- Reposted by Silas ManiatisThe endoplasmic reticulum donates lipids through a tunnel-like protein to help lysosomes expand. Learn more in a new #SciencePerspective: scim.ag/45GWQrS
- Reposted by Silas Maniatis[Not loaded yet]
- Reposted by Silas ManiatisWrote a eulogy for the yellow letters in my office window. www.thecrimson.com/article/2025...
- Reposted by Silas ManiatisOut today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism. www.nature.com/articles/s41...
- Reposted by Silas Maniatisbig one! a decade in the making. nadler & team develop tools to track lipid transport in living cells at single-species resolution. turns out non-vesicular, asymmetry-driven transport is the main architect of organelle identity. feels like the dawn of a golden era for lipid biology. rdcu.be/eBGJv
- Reposted by Silas ManiatisShiny new probabilistic model, gruyere 🧀, for powering up rare variant associations w/ DL effect prediction! We find novel associations for Alzheimer's disease, e.g. nuclear pore protein NUP93 in microglia. Big thanks to NIH/NIA/ADSP and Anjali for the hard work! authors.elsevier.com/a/1ldzwgeXDzHj
- Congrats @kieranrcampbell.bsky.social and co!
- "The perfect segmentation doesn't ex—" —@kieranrcampbell.bsky.social. www.nature.com/articles/s41...
- Reposted by Silas ManiatisUnbelievable footage from NOAA’s Hurricane Hunters inside the eye of Hurricane Erin. Simply incredible.
- Reposted by Silas ManiatisFlyBase, a Drosophila database, will lose a third of its team in early October because the Harvard grant that covered the employees’ salaries was canceled. Scientists warn that losing FlyBase could devastate fly research. By @claudia-lopez.bsky.social www.thetransmitter.org/community/ha...
- What a disaster for the United States and the world. Not only does this purported policy inject political nonsense into rational decision making and claim to give the authority to revoke funding at any time, it fundamentally undermines the credibility of American science and scientists…. /n
- Good chance I would not be a scientist if CPB had not funded @pbs.org programs like Nova and Nature. 3 2 1 Contact, Electric Company, and McNeal Lehrer News Hour were pivotal in my intellectual development too. What a crime against this country this nihilistic nonsense is. cpb.org/pressroom/Co...
- Congrats Megan, Harm, @davidaknowles.bsky.social @nevillesanjana.bsky.social and co! Really nice paper and a great toolset for the community to interrogate the biological relevance of isoform usage!
- Excited for this to be out officially! It was a great team effort and has a lot of useful tidbits for studying isoform function. www.nature.com/articles/s41...
- Former @1199seiu.org member here… Great to see that unlike DNC leadership, my former local gets what’s up. Even if you made the mistake of thinking corporate Dems were the way to go in the primary, you get behind the guy energizing the base.
