Mathieu Dedenon
PostDoc, Kruse lab at UNIGE, working on active living matter and tissue mechanics.
Former PhD at Curie institute on cell & tissue mechanics.
- Reposted by Mathieu DedenonRoffay, C., Molinard, G., ..., & Roux, A. (2021). Passive coupling of membrane tension and cell volume during active response of cells to osmosis. Proceedings of the National Academy of Sciences of the United States of America, 118(47), e2103228118. #EpithelialMechanics buff.ly/r1Hj7F6
- Reposted by Mathieu DedenonHappy to highlight our collaborative work from our @ijmonod.bsky.social team with @destriano.bsky.social, B. Goyeau and M. Chabanon. Cytoplasmic crowding acts as a porous medium that hinders macromolecular diffusivity. Plus: a clever way to measure cell volume. www.pnas.org/doi/10.1073/...
- Reposted by Mathieu DedenonThis weekend we projected cells and filaments on the roof of the @museeorsay.bsky.social in Paris, then we contracted it with a pinch of myosin. And it was fabulous! Grateful to have been part of this art/science project & thx to @manuelthery.bsky.social @lblanchoin.bsky.social & the CytoMorphoLab
- Reposted by Mathieu DedenonAlberto Dinelli, Ludovic Dumoulin, Karsten Kruse: Active topological strings in renewing nematopolar fluids arxiv.org/abs/2601.18307 arxiv.org/pdf/2601.18307 arxiv.org/html/2601.18307
- Reposted by Mathieu DedenonHow do cells orchestrate themselves to achieve a directional movement as a group? Hi, I’m @sayukihirano.bsky.social. In this thread, I’ll highlight key mechanisms of how cells communicate with each other to perform directional collective migration.
- Reposted by Mathieu DedenonNew preprint! We show how mesoscopic nonequilibrium fluctuations in active gels emerge from the breaking of detailed balance at the molecular scale. Warning: Long technical paper ahead! Enjoy! @mpipks.bsky.social @ub.edu @ubics.bsky.social @icreacommunity.bsky.social arxiv.org/abs/2601.20483
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- Reposted by Mathieu DedenonGuillaume Pernollet shows that epithelial cells adjust their shape to locally flatten, forming scutoids for any geometry, changing our view of cell packing. Thanks to all! @clairedessalles.bsky.social @juanmagararc.bsky.social @sciencesunige.bsky.social www.biorxiv.org/content/10.6...
- Reposted by Mathieu DedenonHow can embryos use pulsatile contraction to shape tissue development during morphogenesis? I'm @weiyiqian.bsky.social and with this thread I want to introduce the roles of pulsatile actomyosin in animal development and the mechanisms that drive actomyosin to pulse
- Reposted by Mathieu DedenonHow can structures at the vertex of 3 cells have effects at the tissue level? Join me, @laura-rustarazo.bsky.social, to explore how tricellular junctions (TCJs) act as local tension sensors and regulators of global tissue organization. 🧵⤵️ doi.org/10.1126/scie...
- Reposted by Mathieu DedenonHappy 2026! May this year be good for your cells, Discovering all the cool #EpithelialMechanics as well.
- Reposted by Mathieu DedenonJanssen, V., & Huveneers, S. (2024). Cell–cell junctions in focus–imaging junctional architectures and dynamics at high resolution. Journal of Cell Science, #EpithelialMechanicsReview doi.org/10.1242/jcs....
- Reposted by Mathieu DedenonNew paper out! We show how mechanosensitive adherens junction proteins link actomyosin contractility to actin assembly using in vitro reconstitution. Huge congrats to Aurélie Favarin, Rayan Said, & all authors! In Science Advances: www.science.org/doi/10.1126/... #actin #myosin #mechanobiology
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- Reposted by Mathieu DedenonTristan Guyomar and I wrote a review on physical mechanisms coordinating regeneration - Featured: signalling/mechanical gradients, travelling waves and nematic fields - Dramatis personae: axolotls, hydra, planaria, spiny mice and zebrafish (ofc) with a jellyfish cameo tinyurl.com/3upzrdbs
- Reposted by Mathieu DedenonNon-motile microbes are not prisoners of diffusive transport. Just their metabolic activity can be sufficient to stir up the ambient fluid and cause explosive long-range dispersal -- a "metabolic firework". Our latest work -- arxiv.org/abs/2512.16288
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- Reposted by Mathieu DedenonCytoskeleton shapes tissues during development. What signaling drives these changes? I'm @onenimesa.bsky.social and let's explore FGF signaling's crucial role with examples. Trust me, you need to know this!
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- Reposted by Mathieu DedenonHello, here is a review I wrote about how cells sometimes try to synchronise with surrounding cells so that they can do a good job of building tissues during development. It is called "Keeping up with the neighbours" link.springer.com/article/10.1... #DevBio 🧪
- Reposted by Mathieu DedenonCells can sense the geometry of their environment, from tiny subcellular features to whole-tissue patterns. How can we engineer environments to systematically probe these responses? 🧵 I'm @lhinderling.bsky.social from @olivierpertz.bsky.social lab, let’s do a short tour on microfabrication!
- Reposted by Mathieu DedenonHi bsky! How do cells coordinate fate with migration during development? 🐣 Turns out EMT doesn't just drive cell behaviour changes... it actively primes BMP signalling competence, creating a reciprocal coupling that drives collective invasion! (@bensteventon.bsky.social lab) tinyurl.com/2ncc8zap
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- Reposted by Mathieu Dedenon📢Internships on cellular nematics! 🔬Come for the pretty images, stay for the cool physics: each project combines in vitro experiments with advanced microscopy and image analysis. 📧Feel free to DM or email me with any questions.
- Reposted by Mathieu DedenonNew preprint! Do you like ocean waves? We found similar waves on bacterial colonies! We found that this collective behavior, known as rippling, is nothing but surface waves on an active nematic. @princeton.edu @mpipks.bsky.social @ub.edu @icreacommunity.bsky.social www.biorxiv.org/content/10.1...
- Reposted by Mathieu DedenonTissue stress measurements — our latest preprint is out: arxiv.org/abs/2512.00550 (publication coming soon!) Fantastic work by the three musketeers — @luanger.bsky.social, @andreasschoenit.bsky.social and @fanny-wodrascka.bsky.social — in collaboration with P. Marcq!
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- Reposted by Mathieu DedenonNew preprint from the lab!!🎉 We show that Asgard archaea ESCRT-III proteins can trigger membrane fission and reveal its molecular mechanism, offering clues to how these cells may have built internal compartments. But do these organisms even have these compartments? www.biorxiv.org/content/10.1...
- Reposted by Mathieu DedenonOur paper is out in Nature Communications! We combine two-photon microscopy and active foam modeling to show how cell-scale mechanics control the viscoelasticity and fusion of tissue spheroids, linking single-cell behavior to tissue-level properties. 🔗 www.nature.com/articles/s41... #ActiveMatter
- Reposted by Mathieu DedenonNew paper from the @rouxlab.bsky.social on Nature Communications! We study how membrane tension is spatially organized in cells. Using the mechanosensitive probe Flipper-TR to visualize tension across the plasma membrane of adherent cells and to dissect the conditions needed for a gradient to happen
- Reposted by Mathieu Dedenon🚨@TLM_Cambridge Online Seminar - 03.12.25 | 16:00 UK Ben Fabry (@ben-fabry.bsky.social): "Universal scaling laws in cell and tissue rheology" Please RT & to attend online please register to our 📧: lists.cam.ac.uk/sympa/subscr...
- Reposted by Mathieu DedenonThrilled to see this new preprint from Rupprecht lab out — happy I could contribute with my rotating rings. May the science keep spinning. 🔄✨
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- Reposted by Mathieu DedenonVery happy to share video of 1st lecture @college-de-france.fr on Biological computation 😊. I defend the necessity to access Algorithmic & Computational levels of analysis in cell & developmental biol. proposed by David Marr in neuroscience. Logic & Function matter 🤩. Video: tinyurl.com/55yejk5f
- Reposted by Mathieu DedenonThe law of the jungle. Interactions of cells in a collective lead to global rotation. In 80% of the case HUVEC cells turn clockwise. How many cells does it take for this to happen?
- Reposted by Mathieu DedenonIt’s time to talk about epithelial geometry and cancer. How can the architecture of an epithelium affect how tumors will grow and spread? In this thread, @jorgealmagro.bsky.social
- Reposted by Mathieu DedenonWhy would Mycobacterium shed its surface right after entering a host cell? Host phagocytes rapidly strip its outer layer, releasing components that alert neighbors and trigger defense responses Our preprint is out, curious to hear your take! 👀 www.biorxiv.org/content/10.1...
- Reposted by Mathieu DedenonThe lab’s first pre-print! We investigated how growth-inducing Erk activity waves are regulated in regenerating zebrafish scales. We discovered that Erk waves are followed by waves of expression of their own inhibitors, as predicted by excitable waves theory. tinyurl.com/26r2cmpj
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- Reposted by Mathieu DedenonMaria Tettamanti shows that inhibition of TORC2 by the small amphipath PalmC induces the TORC2-dependent internalization of sterols. Congrats to Maria and all coworkers involved, and to EMBOj for the efficient review process: use review commons! @biology-unige.bsky.social @sciencesunige.bsky.social
- Yeast cells utilize a TORC2 feedback loop for plasma membrane adaptation to mechanical stress, with increased sterol transport from plasma membrane to endoplasmic reticulum activating TORC2 signaling Robbie Loewith, Aurélien Roux @rouxlab.bsky.social and coworkers www.embopress.org/doi/full/10....
- Reposted by Mathieu DedenonHi, I’m David Brückner @davidbrueckner.bsky.social. I’ll take you through how cells in a tissue can use information distributed by biochemical gradients to make decisions, and how we can measure such positional information. buff.ly/RFxVeHh
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- Reposted by Mathieu DedenonMicrofluidic pumping with active nematics! Self-organized and self-sustained. No external pumps. @pnas.org @ub.edu www.pnas.org/doi/10.1073/... #ActiveMatter #Microfluidics #SoftMatter
