dandergassen
Independent Junior Group Leader at TUM - Postdoc in the Rinn & Meissner Lab (Harvard) - PhD in Denise Barlow's lab (CeMM)
- Reposted by dandergassenVery happy to share our paper rdcu.be/eUImj out today in @natcellbio.nature.com 🎉🎉🎉 We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.
- Reposted by dandergassen📣 Yesterday our study uncovering the ancestry bias in gene annotations was finally published in @natcomms.nature.com! www.nature.com/articles/s41... If you work in human genetics or transcriptomics, do not miss our tweetorial!👇 @guigolab.bsky.social @bsc-cns.bsky.social @crg.eu
- Giving a seminar today @ethz.ch on our new X-reactivation findings during aging—back at the institute where I started my PhD 10 years ago. Can’t wait to see some familiar faces!
- Reposted by dandergassen📣 SAVE THE DATE Next X-inactivation meeting in Sapporo, Japan, 19-23 October 2026. Visit x-inactivation-meeting.org to join our mailing list. 🧬 speakers @dandergassen.bsky.social @marnieblewitt.bsky.social @heard65.bsky.social @crougeulle.bsky.social @sexchrlab.bsky.social @zhouqi1982.bsky.social
- New paper from the lab: we’re using long-read sequencing to disentangle isoform complexity at allele-specific loci 🧬💡 Here, we combine the PacBio Iso-Seq workflow with the established WhatsHap phasing approach to assign long reads to the correct allele in polymorphic F1 mouse hybrids.
- We explored imprinted loci, known for allele-specific coding and non-coding isoforms, and successfully benchmarked historical findings. Our approach also uncovered isoforms expressed from both the active and inactive X chromosomes of escape genes in females.
- This workflow provides a powerful and accessible framework for studying allele-specific transcript diversity, highlighting the mechanistic insights made possible by long-read transcriptomic data.
- This work, led by Lison Lemoine and co-authors @sarahhoelzl.bsky.social, @hasenbeint.bsky.social and Elisabeth Graf @tum.de, has been published today in Scientific Reports: www.nature.com/articles/s41...
- Cracking the code of the non-coding genome via allele-specific genomics? Can we link non-coding elements—like lncRNAs and enhancers—to their protein-coding target genes, and in doing so, connect overlapping non-coding disease variants to their protein-coding counterparts?
- Yes! The Allelome.LINK framework integrates allele-specific transcriptomics and/or epigenomics to connect cis-acting lncRNAs and enhancers with their nearby protein-coding targets, thereby linking overlapping non-coding disease variants to the genes they affect.
- This work, led by @hasenbeint.bsky.social and co-authors @sarahhoelzl.bsky.social, Stefan Engelhardt at the @tum.de #TRR267, has been published in @narjournal.bsky.social link: doi.org/10.1093/nar/...
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View full threadAll mouse (6 major organs) and human (54 GTEx tissues) lncRNA-to-target predictions are easily accessible for visual inspection, allowing researchers to select candidates based on target and mechanism predictions GitHub IGV resource link: github.com/AndergassenL...
- Reposted by dandergassen📢 Paper Alert: tinyurl.com/yzy2d864. We characterized tRNA-overlapping lncRNA loci = tROLs! tROL perturbations silence codon-biased genes in inter-chromosomal proximity. tROLs bridge the non-coding and coding genomes. @sickkidsto.bsky.social @uoftpress.bsky.social
- Reposted by dandergassenOur study on a male-essential microRNA and the evolution of other dosage compensation mechanisms in birds is now out in Nature! www.nature.com/articles/s41...
- Reposted by dandergassen🗞️Our June issue is live!📷 This month, we're featuring work on editing epigenetic age, somatic mutation, senescence, Alzheimer’s biomarkers and much more. Read it all here: nature.com/nataging/vol...
- We are so happy to be on the cover @sarahhoelzl.bsky.social 🎉 The cover depicts the Three Fates, who manipulate the threads of life and death. The Fates are shown as three older women, unraveling the threads of the inactive X chromosome during aging. www.nature.com/nataging/vol...
- Reposted by dandergassenWhy do women experience aging-related diseases differently than men? A new study shows that with age, genes on the inactive X chromosome can reactivate – potentially influencing conditions like #dementia and #autoimmunity: go.tum.de/987255 #genetics #aging 📷 @dandergassen.bsky.social
- Reposted by dandergassenWe're excited to publish our latest study led by Bryony Leeke @bryonyleeke.bsky.social and Wazeer Varsally, now out in @nature.com 🍾This study focusses on the epigenome of marsupial embryos 🦘 mapping DNA methylation in embryo development to specific embryo events www.nature.com/articles/s41... 🧵
- Reposted by dandergassenOur new contribution to the quest to find causal GWAS genes! Sam Ghatan from my lab at @nygenome.org led a systematic comparison of eQTLs and CRISPRi+scRNA-seq screens. TL;DR: they provide highly complementary insights, with ortogonal pros and cons. 🧵👇 www.biorxiv.org/content/10.1...
- Reposted by dandergassenDo you work in 💫human genetics💫? Have you ever worried about what’s inside your gene annotation GTF⁉️ WELL, YOU SHOULD! 😱 Especially when studying a genetically diverse 🌍 cohort! 🔴We discover that gene annotations are European-biased 👉 impacting downstream analyses! Don't miss this thread🧵⬇️ 1/13
- I’m incredibly proud to share the results of our lab’s first project, leading to the exciting discovery – Aging promotes reactivation of the Barr body at distal chromosome regions – now published in @nataging.nature.com! 🔗 tinyurl.com/3jkzzy7d
- This discovery was driven by the outstanding work of @sarahhoelzl.bsky.social, together with co-authors @hasenbeint.bsky.social, Stefan Engelhardt, @tum.de - @dzhk.de, @erc.europa.eu 🙌 .
- Decades ago, evidence for age-specific X-reactivation came from the observation that a single gene escapes silencing during aging. While stable Barr body inactivation is crucial for balancing gene dosage between sexes, its maintenance during aging remains unclear. Until now! ⌛️
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View full threadFinally, we would like to thank all the reviewers for their valuable comments, the @nataging.nature.com editors, as well as Anton Wutz for highlighting our research in the News & Views section of Nature Aging: rdcu.be/eknAp
- Reposted by dandergassenOnline now!✨RESEARCH: @sarahhoelzl.bsky.social et al demonstrate that aging promotes reactivation of the inactive X chromosome in mice, and catalog escape genes using multi-omics @dandergassen.bsky.social www.nature.com/articles/s43... rdcu.be/ekm0I
- Reposted by dandergassenExcited to share our lab’s first review, focusing on RNA localization! #RNA #RNAlocalization genomebiology.biomedcentral.com/articles/10....
