Irene Chiolo
Geneticist and cell biologist at the University of Southern California | DNA repair | heterochromatin | recombination | nuclear dynamics | nuclear architecture | genome stability.
- Reposted by Irene ChioloAnother paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...
- Reposted by Irene ChioloOnline Now: Off-pore Nup98 condensates mobilize heterochromatic breaks and exclude Rad51 Online now:
- Reposted by Irene ChioloHappy to share the latest story from @arnaudkr.bsky.social's lab @embl.org! With @guidobarzaghi.bsky.social, we used Single Molecule Footprinting to quantify how often chromatin is accessible at enhancers after TF and chromatin environment changes! Check our preprint bit.ly/3XQMFxN + thread ⬇️ 1/11
- Reposted by Irene ChioloEasily one of the most beautiful live-cell imaging papers out there! Amazing contribution to chromosome tracking during mitosis with huge prospects for further discoveries concerning chromosome behavior. Check it out @naturecellbiology.bsky.social
- We’re excited to share our work where we investigated the mechanisms of chromosome motion by tracking all #chromosomes, mapping their interactions, and live cell karyotyping, using #AI based denoising, segmentation and registration, published in Nature Cell Biology. www.nature.com/articles/s41...
- Reposted by Irene ChioloNew preprint from our lab! Why is not everyone working on Transposons? Loss of H3K9me3 maintenance in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons www.biorxiv.org/content/10.1...
- Reposted by Irene ChioloExcellent thread on the paper from Meneu, Chapard et al. The latest from the Koszul and friends lab! www.science.org/doi/10.1126/...
- Reposted by Irene ChioloOne of the co-Editors-in-Chief (Martin Kulldorff) published a "Perspective" entitled "A Blueprint for NIH Reform". publichealth.realclearjournals.org/perspectives... 2/n
- Reposted by Irene ChioloPeter Marks’s resignation letter. Everyone should read this.
- Reposted by Irene Chiolo📢The programme for #DDRCT25 is now available! Visit our website to explore the exciting sessions, speakers, and key topics we have in store. ➡️Check it out here: fusion-conferences.com/conference/177
- Reposted by Irene ChioloCheck out our review on DNA end resection! With Raphael Ceccaldi, www.nature.com/articles/s41...
- Reposted by Irene ChioloOur new findings on how chromosomes get ready for cell division are now published in @cellpress.bsky.social! Congratulations, Kai, @andibrunner.bsky.social and everyone else involved! 🤩 www.sciencedirect.com/science/arti...
- Did you know that DNA must form overlapping loops to give rise to the well-known X-shape of chromosomes? 🧬🧪 New research from EMBL's Ellenberg Group provides new insights into the process of chromosome formation. @ellenberglab.bsky.social @andibrunner.bsky.social www.embl.org/news/science...
- Reposted by Irene Chiolo🚨 Excited to announce the 2nd Spatial Genome Organisation Conference! #SGO25 📅 Oct 31–Nov 3, 2025 | 📍 Riviera Maya, Mexico 🪑 Chairs: @altmeyerlab.bsky.social, @chiololab.bsky.social, @karimmekhail.bsky.social 🔗 Registration: fusion-conferences.com/conference/188 Please 🔄 ❤️
- Reposted by Irene ChioloLanding on Bluesky by sharing the latest preprint from the lab: nucleoplasmic Lamin A/C modulates RECQ1-mediated fork restart upon mild genotoxic stress, by regulating heterochromatin marks and ADP-ribosylation levels at replication factories www.biorxiv.org/content/10.1...
- Reposted by Irene Chiolo📣 Join us for #EESNucleus 🧬 Explore the dynamic world of the nucleus at the new EMBO | EMBL Symposium. From nuclear mechanics to pathomechanisms, join the conversation shaping modern cell biology. 🗓️ 18 – 21 November 2025 📥 Submit your abstract by 26 August 👉 s.embl.org/ees25-07-bl
- Reposted by Irene ChioloAs federal funding for research is uncertain, we need to diversify funding sources for our PhD students. Here is a comprehensive list of >160 PhD fellowships and funding opportunities, mostly from private foundations and scientific societies. Download it here: research.jhu.edu/rdt/funding-...
- Reposted by Irene ChioloExciting seminar series from Genome integrity italian Network (GiiN), chaired by myself and Raffaella Di Micco! Short talks (2x30’), at convenient time for EU/USA attendees. Big shots and raising stars in an expanding field. See flyers + link to receive email alerts. Please repost to your network!👇
- Reposted by Irene ChioloNew discovery from our #CDlab reported in Cell @cp-cell.bsky.social today: SMC motor proteins have a left-right ‘gearbox’ and can switch direction in DNA loop extrusion! www.sciencedirect.com/science/arti... 1/
- Reposted by Irene ChioloI put together a small guide on how to get started with Fiji. Please distribute to anyone who might benefit form this! zenodo.org/records/1477... #imageanalysis #fiji #imagej #training
- Reposted by Irene ChioloA unified model for cohesin function in sisterchromatid cohesion and chromatin loop formation: Molecular Cell www.cell.com/molecular-ce...
- Reposted by Irene Chiolo1/Out today in @naturecomms.bsky.social, “A CPC-shelterin-BTR axis regulates mitotic telomere deprotection”. Here we identify the mechanism that unwinds telomere-loops (t-loops) during mitotic arrest to activate the DNA damage response and signal mitotic stress. www.nature.com/articles/s41....
- Reposted by Irene Chiolo🚀 New Paper Alert! Our latest @natrevmcb.bsky.social explores how nuclear and genome organization drive DNA double-strand break repair! 🧬 📖 Free access: rdcu.be/edViW Please 🔄 ❤️
