Rebecca Gladstone
Bioinformatician, microbial genomics, 🤓 💙 Pneumo, E. coli, capsules, AMR, vaccine evaluation and general adventure seeker living in Norway.
- "Machine learning-based lineage prediction from antimicrobial susceptibility testing phenotypes for Escherichia coli sequence type 131 clade C surveillance across infection types" Spoiler: the MDR ST131-C is pervasive in UTIs, underlying BSI trends. doi.org/10.1099/mgen... @microbiologysociety.org
- This was a really fun study in collaboration with Theodor A. Ross and colleagues @uitnorgesarktiske.bsky.social @sfi-vi.bsky.social, training a model to predict the ST131-C genotype from antimicrobial susceptibility testing data, providing insight into its UTI prevalence and context for BSI trends.
- Reposted by Rebecca GladstoneNew preprint: we looked into production of the bacterial toxin colibactin and found that MDR E. coli from the global north have co-evolved with endemic colibactin producers, acquiring colibactin resistance genes before undergoing clonal expansions. www.biorxiv.org/content/10.1...
- Reposted by Rebecca GladstoneImagine we could travel back in time ⏪⌛️to explore the world of bacterial pathogens before humans discovered and industrialised antibiotics We just did that to study the history of #AMR spread @science.org doi.org/10.1126/scie... If you like time travel & biology, this 🧵is for you👇
- Reposted by Rebecca GladstoneNew preprint reveals bacteria can't just collect all resistance genes like Pokemon cards. We found mutually exclusive evolutionary pathways to multidrug resistance in E. coli & P. aeruginosa - some resistance mechanisms actively prevent others from coexisting www.biorxiv.org/content/10.1...
- Being able to data plasmid acquisition, and to see the diversity of plasmids being gained and lost from lineages, was really eye opening! It was a pleasure to contribute my tiny bit to this huge paper and the data has so much more to give! @arredondo.bsky.social @gerrythill.bsky.social et al.
- Reposted by Rebecca GladstoneI'm putting together a Microbial Bioinformatics starter pack to help get everyone connected in our community. Let me know if there are any bluesky users to be added and share so that twitter refugees can tune back in to the fantastic world microbes go.bsky.app/3ezLo7eat://did:plc:q5tlivvxn74iprf3fvm67xdm/app.bsky.graph.starterpack/3lfeqdhboxy2s
- Reposted by Rebecca GladstoneWe are hiring remote bioinformaticians at @theiagen . If you have a passion for microbial bioinformatics or public health, send your CV to careers@theiagen.com . You can be based nearly anywhere but need to be available to work US business hours.
- Reposted by Rebecca Gladstone[Not loaded yet]
- Reposted by Rebecca GladstoneInteresting and useful post from Altmetric. TDLR: 🎉 BlueSky is an awesome place to share research. ❌ Don’t use link shorteners (unless it’s the DOI one) ✅ Keep the link in the post (don’t remove it once you have the auto-preview) #AcademicSky #PhDSky
- Reposted by Rebecca GladstoneNew paper: We show that population exposure to colibactin producing E. coli lineages ST95 and ST73 largely explains global variation in colorectal cancer incidence. Same STs are also major causes of UTIs and may be similarly involved in urinary tract cancers. www.sciencedirect.com/science/arti...
