Adrian Cazares

cazares-adr.bsky.social

Bacterial Mobile Evolution. Staff Scientist at Sanger Institute. I study how pathogens emerge and evolve by sharing genes. Interested in AMR, Plasmids, Phages, ICEs, and everything that moves within and between genomes.

Joined September 2025

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Zamin Iqbal handle.invalid · Oct 17, 2025
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Reposted by Adrian Cazares
Michael Brockhurst brockhurstlab.bsky.social · Oct 6, 2025
New preprint! Ever wondered why only a fraction of genomes encode CRISPR immunity? 🧬 🦠 Turns out CRISPR is rarely beneficial against virulent phages, being most beneficial against those for which resistance mutations are rare! An epic effort by Rosanna Wright www.biorxiv.org/content/10.1...
Resistance mutation supply modulates the benefit of CRISPR immunity against virulent phages

Only a fraction of bacterial genomes encode CRISPR-Cas systems but the selective causes of this variation are unexplained. How naturally virulent bacteriophages (phages) select for CRISPR immunity has...

biorxiv.org

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Adrian Cazares

Resistance mutation supply modulates the benefit of CRISPR immunity against virulent phages