Aurélien Villedieu
Postdoc in Jérôme Gros's team | Former PhD student in Yohanns Bellaïche's team | Multi-scale study of tissue morphogenesis | Live-imaging and quantitative biology
- Reposted by Aurélien VilledieuI’m pleased to share our latest preprint (my first as 1st-author) from Jérôme Gros’ group (@jeromegros.bsky.social), now on bioRxiv. It reports actin and myosin dynamics during epithelial remodeling in avian gastrulation. (doi: doi.org/10.64898/202...)
- Reposted by Aurélien VilledieuWnt and Nodal asymmetries stratify mouse laterality phenotypes in the absence of node flow biorxiv.org/content/10.64898/20…
- Reposted by Aurélien Villedieu#RésultatScientifique 🔎 | Comment les filaments d'actine s'organisent à l'intérieur des cellules et des tissus vivants 🔬 @institutfresnel.bsky.social 🤝 @univ-amu.fr @centralemed.bsky.social @cnrs.fr 📍 @cnrs-dr12.bsky.social
- Reposted by Aurélien VilledieuOut today. 🙏 again to everyone for this wonderful piece of work, in particular to Aurelie @aurhin.bsky.social Chase @chasebolt.bsky.social and Brent @homeobox.bsky.social. 🙏 also to the Harris lab @fish4walking.bsky.social and @neilshubin.bsky.social @biology-unige.bsky.social @college-de-france.fr
- Reposted by Aurélien VilledieuWe are all super happy and proud to see our work on the function and evolution of the #cephalic #furrow published in @nature.com. Let me say a few things about the background and history of this work on the #Evolution_of_Morphogenesis (1/12)
- Reposted by Aurélien VilledieuOur latest: We developed a chemo-optogenetic system for precise spatiotemporal control of morphogen production. Using dual light + small molecule control of Sonic Hedgehog production, we recapitulated neural tube patterning in vitro & measured spread of Shh 🧵 www.sciencedirect.com/science/arti...
- Reposted by Aurélien VilledieuLatest paper elifesciences.org/articles/107... closes an important cycle in our efforts to study regeneration: week-long recordings allow us to observe the behaviour of cells during the entire course of regeneration in a crustacean leg – bright objects in movie are fluorescent nuclei of cells. 1/6
- Reposted by Aurélien VilledieuVery happy that the first article from my postdoc work in the Tomancak lab is now published @PNAS! www.pnas.org/doi/10.1073/.... We studied the self-organization of actin in aggregates made from Hydra cells. Thread below (1/9)
- Reposted by Aurélien VilledieuFinally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁 Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
- Reposted by Aurélien VilledieuIf you’ve been following this account closely, you might already know methods to probe mechanics in vitro, but what about in live embryos? I’m @amichaut.bsky.social, and I’m going to share a few great papers on this aspect of #EpithelialMechanics.
- Reposted by Aurélien VilledieuHere is what I have been up to in the lab of @stephangrill.bsky.social together with @neipel.bsky.social and many others. Intrigued by avian left right symmetry breaking we found that a tissue-scale active torque drives chiral flow and requires mechanical coupling to the underlying tissue.
- (1/10) I am excited to finally share our work on avian left/right symmetry breaking with you. We reveal a tissue-scale active torque dipole generated at the Hensen’s node, thanks to crazy experiments by Julia @juliapfanzelter.bsky.social and some analysis by me. doi.org/10.1101/2025...
- Reposted by Aurélien Villedieu🏳️🌈Our editor @slefkopoulos.bsky.social discussed with @jzylicz.bsky.social about the importance of celebrating Pride, representation in science, and more! Happy Pride! Read here: rdcu.be/ewfba bit.ly/3Uc72TO
- Many thanks to Ruoheng Li and @prelights.bsky.social for featuring our preprint!
- Seeing and (not) believing! On the role of hypoblast in primitive streak induction. In her second #preLight, Ruoheng Li covers the #preprint by @aurelienvilledieu.bsky.social and the @jeromegros.bsky.social's research team.
- 🚨 A very interesting conference on gastrulation coming up soon 🚨 Don't miss the chance to interact with these renowned speakers! Early bird deadline: July 15th
- Registration is now open! Gastrulation Reloaded: Developing, engineering & evolving the body plan 📅 October 14–17, 2025 📍 Paris, France 🗓️ Abstract & early bird deadline: July 15, 2025 www.gastrulation-reloaded.conferences-pasteur.org/home Exceptional lineup of speakers & many selected talks
- Reposted by Aurélien Villedieu🧵Just out ! We reveal how 4 branched epithelia—mammary, lacrimal, salivary & prostate—use a conserved YAP–Notch–p63 circuit to self-organize during development & regeneration. Here’s the story👇 authors.elsevier.com/c/1lM285Sx5g... Work done in @frelab.bsky.social at @institutcurie.bsky.social
- Reposted by Aurélien Villedieu🥳 Thrilled to share our lab's first preprint, led by our talented postdoc Justine Creff! 👩🏻🔬 We tackled a fundamental question: how the epithelium withstands mechanical stress at the interface of cells with distinct geometries and mechanics, such as enterocytes (E) and goblet cells (G) (1/9)
- Reposted by Aurélien VilledieuVery happy to share our latest lab publication! The hard work of @bboumard.bsky.social, Gwenn Le Meur and collaborators! Cell-type-specific nucleotide sharing through gap junctions impacts sensitivity to replication stress in Drosophila: Developmental Cell authors.elsevier.com/a/1lDFi_Yv6z...
- Reposted by Aurélien VilledieuThe effector caspases drive cell death, but their activation can often be survived, so how do cells make this decision? Our new preprint from @levayerr.bsky.social shows that instantaneous caspase activity is important, but past activation has a key role to play! www.biorxiv.org/content/10.1...
- 🚨New preprint Glad to share my postdoc work on the role of the hypoblast in primitive streak induction! Discover how live imaging observations led us to revisit the molecular mechanisms governing embryonic axis induction Thanks to @jeromegros.bsky.social and all co-authors! doi.org/10.1101/2025...
- In birds and mammals, primitive streak formation is thought to occur when an anterior movement of the hypoblast (visceral endoderm in mice) lifts its inhibition on the posterior epiblast, allowing NODAL signaling activation. However, in birds, a precise description of this movement was lacking.
- We have adapted live-imaging techniques previously used to characterize tissue flows in the avian epiblast to describe, this time, tissue flows in the hypoblast. This allowed us to discover that, like the epiblast, the hypoblast exhibits counter-rotating flows (also known as Polonaise movements).
-
View full threadOur results thus show that primitive streak formation is induced by NODAL activation in the posterior hypoblast. The movement of the hypoblast (which is a counter-rotating movement) is a consequence of primitive streak formation – and not a cause of it, as previously thought.
