Denis Krndija
new group leader @CBIToulouse | MechanoGut team | ATIP-Avenir | fascinated by the dynamics and mechanics of the #gut 🐭⚙️🔬| he/his/him 🏳️🌈
Lab: cbi-toulouse.fr/eng/equipe-krndija
Personal: cbi-toulouse.fr/eng/page-personnelle-49
- Reposted by Denis KrndijaHappy to highlight our collaborative work from our @ijmonod.bsky.social team with @destriano.bsky.social, B. Goyeau and M. Chabanon. Cytoplasmic crowding acts as a porous medium that hinders macromolecular diffusivity. Plus: a clever way to measure cell volume. www.pnas.org/doi/10.1073/...
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- Reposted by Denis KrndijaNew paper out! We show how mechanosensitive adherens junction proteins link actomyosin contractility to actin assembly using in vitro reconstitution. Huge congrats to Aurélie Favarin, Rayan Said, & all authors! In Science Advances: www.science.org/doi/10.1126/... #actin #myosin #mechanobiology
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- Good times at our traditional Christmas team lunch today 🎄🥂 It was a year full of exciting results, marked by our first PhD student graduating and two preprints published! Very grateful for this team and all that we’ve achieved together over the past four years. Looking forward to what’s next! 🙏✨
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- Reposted by Denis KrndijaWe finally made it over here ! And excited to share our new paper on mechanical forces regulating stem cell plasticity in colorectal cancer, involving force transduction via mechanosensitive calcium channels! www.cell.com/cell-reports...
- Great opportunity - check it out!👇🤩
- We are looking for: PhD Student (starting as Research Assistant) and Postdoctoral Researcher in Stem Cell Biology and Mechanobiology. Please RT💕 🔗 About our lab: renew.science/principal_in... 🎓 PhD position: jobportal.ku.dk/phd/?show=15... 🧪 Postdoc position: jobportal.ku.dk/videnskabeli...
- Reposted by Denis KrndijaDelighted that Ziqi Dong's PhD paper is out for all to read! Hypoxia is fundamental to normal development, and fascinating! Thanks to all of our co-authors including @jamesnathanlab.bsky.social @jellevda.bsky.social authors.elsevier.com/sd/article/S...
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How do cells navigate up gradients of adhesive proteins? 🤔 Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood We show that passive friction directs cells & explains complex trajectories on gradients 👉 www.nature.com/articles/s41... - Ever wondered how adult organs preserve epithelial barrier integrity while continuously exposed to mechanical stress? We tackled this question in our new preprint – led by our brilliant PhD student Vishnu Krishnakumar! (1/11) 🔗 www.biorxiv.org/content/10.1...
- Mechanical forces shape tissues throughout development and physiology – yet in vivo evidence for mechano-adaptation in adult organs remains scarce. The colon must regularly accommodate voluminous faeces, but how it adapts to this load while maintaining barrier integrity was unknown (2/11)
- Reposted by Denis KrndijaThe PhD work of @bboumard.bsky.social officially out in print! Happy to share this issue with our downstairs colleagues in the BDD @frelab.bsky.social @robinjournot.bsky.social www.cell.com/developmenta...
- Reposted by Denis KrndijaCan pressure gradients persist over long timescales in animal cells? We induced intracellular pressure gradients and examined the resulting flows in single cells. We reveal surprisingly long lasting pressure gradients. More here: elifesciences.org/reviewed-pre...
- Reposted by Denis KrndijaOur paper is on the cover of @cp-devcell.bsky.social . Image: embryonic murine salivary-gland explants stained for fate determinants; p63 (cyan) and HES1 (yellow). Thanks to everyone involved. doi.org/10.1016/j.de...
- Reposted by Denis KrndijaLatest from ours: www.cell.com/cell-reports... This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵
- Reposted by Denis KrndijaAre you interested on how regenerating tissues transit between stages? Am sharing here our work showing that during #Xenopus tail regeneration, tissue stiffening activates a Piezo1-Yap1 mechanosensitive cascade to allow wounded epithelia to transit into regenerative states!
- Reposted by Denis KrndijaThree-Year Funded Postdoctoral Position to study organelle architecture in mammalian oocytes – Terret-Verlhac Lab, CIRB, Collège de France (Starting 2026). For more information, please contact: marie-helene.verlhac@college-de-france.fr
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- Reposted by Denis KrndijaSynthetic materials accumulate damage with every mechanical challenge. Epithelial tissues are regularly loaded, yet healthy epithelia rarely rupture. Why? We are @epmech.bsky.social and @baldaufsci.bsky.social and in this thread we introduce you to cyclic loading. bsky.app/profile/epim...
- Mechanical forces shape the developing brain 🧠💥 Compression from high cell density doesn’t just squeeze cells - it compromises mitotic fidelity! New preprint on how mechanics impact neural development from Veronique Marthiens & co-authors @institutcurie.bsky.social @cbitoulouse.bsky.social 🧠🔧👇
- Reposted by Denis Krndija🧵Just out ! We reveal how 4 branched epithelia—mammary, lacrimal, salivary & prostate—use a conserved YAP–Notch–p63 circuit to self-organize during development & regeneration. Here’s the story👇 authors.elsevier.com/c/1lM285Sx5g... Work done in @frelab.bsky.social at @institutcurie.bsky.social
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- Reposted by Denis KrndijaStudents (Master's/PhD), do not miss this fantastic Developmental Biology course of @sorbonne-universite.fr and @institutcurie.bsky.social - It is FREE and open to international students, however, room and board + travel are not included. training.institut-curie.org/courses/deve...
- Enjoying great science and stunning alpine views at the GRC on Cell Contact & Adhesion in Les Diablerets 🇨🇭⛰️ Proud of our PhD students Dhriti and Vishnu for their terrific work - posters and talks full of exciting insights! #CellContactAndAdhesionGRC #CellBiology #PhDLife #LesDiablerets
- Reposted by Denis KrndijaInterested in Developmental Mechanics??? We are organizing a mechanobiology workshop in Baeza, Spain, October 21-23, 2025. Come join us (and please help us spread the word)!!!
- Reposted by Denis KrndijaThank you @naturemethods.bsky.social for highlighting our recent paper on "Spatial Mechano-Transcriptomics" in your April Issue: www.nature.com/articles/s41... www.nature.com/articles/s41...
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- Reposted by Denis KrndijaREPOSTING this here just to officially leave "the other place" Our work on the role of endogenous electric fields in guiding collective cell migration during #morphogenesis is out @naturematerials.bsky.social nature.com/articles/s41...
- 🥳 Thrilled to share our lab's first preprint, led by our talented postdoc Justine Creff! 👩🏻🔬 We tackled a fundamental question: how the epithelium withstands mechanical stress at the interface of cells with distinct geometries and mechanics, such as enterocytes (E) and goblet cells (G) (1/9)
- We identified Goblet cell-Associated Fractures (GAFs) 💥 – junctional ruptures between goblet-adjacent enterocytes in normal adult mouse and human intestine! To our knowledge, this is the first example of a self-rupturing tissue under homeostatic conditions! 🧐 (2/9)
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- Reposted by Denis KrndijaAre postdocs the rarest species, or is it just me? We have two funded positions—apply now and join us on these exciting projects! #zebrafish #zebrafishcareers #iPSC #devbio #regeneration
- Reposted by Denis KrndijaAre you passionate about live-imaging microscopy? Do you have a special talent for working with iPSCs? Or are you simply a zebrafish aficionado? 🐟 We have 2 funded postdoctoral positions in our lab (cbi-toulouse.fr/eng/equipe-b...). Join us and apply now! Please spread the word 🙏
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- Reposted by Denis KrndijaInterested in the cell biology of the nucleus? Join us for this unique exciting meeting that covers everything from nuclear biophysics and mechanics to signaling and evolution😍 amazing speaker list and more will be selected from abstracts 🤩
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- Reposted by Denis Krndija🚨🚨🚨 Call is now open!!! Deadline approaching... Wanna become our new beloved colleague and be part of a stimulating (and friendly) scientific community ??? We are perfectly located in beautiful Paris with exciting work environment and state-of-the-art core facilities APPLY 👇👇👇👇👇
- Happy holidays 🎄 and #FluorescenceFriday with this festive mouse colonoid! Work of Amalia Ferran, new PhD student in our team @cbitoulouse.bsky.social 🙏🐭🔬
- Reposted by Denis Krndija❗ANNOUNCEMENT❗ YEN 2025 Conference will be held at @crick.ac.uk on the 19th May 2025. We are looking forward to another exciting line-up with Nicolas Rivron, Maud Borensztein and Peter Rugg-Gunn. This year will see a return of the YEN Image Competition so follow for updates. Share for #YEN2025!
- Curious how the gut epithelium resists mechanical stress while maintaining the barrier? Don’t miss our talented PhD student Vishnu Krishnakumar’s mini-talk on Dec 17, 10:25 AM at #ASCB2024! Check out his poster P2506 too. Thanks to #SBCF, @frm-officiel.bsky.social & @cnrs.bsky.social for support!
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