Amro Hussien
HFSP/EMBO Fellow @MaxPlanck.de (Wickström Lab) | Prev. @ETHZ.ch, @UCL.ac.uk |
First-principles in: #Mechanobiology • #EpigeneticMemories • #Inflammation • #Tendon
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- Reposted by Amro HussienBriefly, after organ injury, 100 milliseconds, we detected collective changes in membrane potential at the tissue level. This is so far the earliest detected wound-response!! This electric signal sparks the formation of a tissue-wide calcium wave👇
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- Reposted by Amro HussienA wonderful piece by @callimcflurry.bsky.social on how mechanosensitive PIEZO ion channels are being used to explore how our bodies rely on pressure sensing. It is a thoughtfully researched article, with perspectives from many colleagues across the field. www.thetransmitter.org/interoceptio...
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- Reposted by Amro HussienScience update from my postdoc Peiyuan Chai - his work “glycoRNA complexed with heparan sulfate regulates VEGF-A signaling” is now published @nature.com uncovering a new layer or glycoRNA-regulation of growth factor mediated control physiological processes rdcu.be/e1bBX
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- Reposted by Amro HussienWe often think of our genes as the script of our fate. But genes are not the whole story. www.quantamagazine.org/how-metaboli...
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- Reposted by Amro HussienA Perspective on 3D traction force microscopy provides practical experimental and computational guidance for users. @barrasa-fano.bsky.social www.nature.com/articles/s41...
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- Reposted by Amro HussienHere is the link to download the PDF of my course#5 on Biological computation. I present & discuss Self-tuning, Adaptation and Learning in biological (non-neuronal) systems, in particular during embryonic development. This course contains various personal ideas/proposals. tinyurl.com/hcpwsbtm
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- Reposted by Amro Hussien☕Cornell et al. show that target cells with low cortical tension induce #macrophages to preferentially trogocytose, or engulf in small fragments, whereas target cells with high #CorticalTension tend towards #phagocytosis. bit.ly/3L7xFIO
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- Reposted by Amro HussienA 2024 study found that ants best humans at tests of collective intelligence. Learn more: scim.ag/42nMvQJ #ScienceMagArchives
- Reposted by Amro HussienNice paper from @robertife.bsky.social on how metabolism-induced H4K16 acylations correlate with (and may cause) chromatin opening through disruption of tail-acidic patch internucleosomal interactions. www.cell.com/molecular-ce...
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- Reposted by Amro HussienMultidisciplinary training, over time, produces the highest impact people www.science.org/doi/10.1126/...
- Reposted by Amro HussienLearn more about Wyss Founding Core Faculty member David J. Mooney in this 20-ish Questions video, which shows a different side of Wyss Institute faculty, touching on aspects of their personal life, hobbies, interests, as well as their research. @harvardseas.bsky.social.
- Reposted by Amro HussienCan one map the genome-wide binding (1) and its protein partners (2) simultaneously from the same sample? Yes, one can. with CUT&ID ✂️🪪 Spearheaded — singlehandedly — by @annanordin.bsky.social No need of transgenesis, cloning and overexpression. Check it out, it's fast and its works.
- CUT&ID for simultaneous profiling of protein-DNA and protein-protein interactions biorxiv.org/content/10.64898/20…
- Reposted by Amro HussienOrganelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
- Organelles harbour pH gradients biorxiv.org/content/10.64898/20…
- Reposted by Amro HussienKJ Muldoon, at less than a year old, was the first known person to receive a personalised CRISPR-based genome-editing therapy He is part of Nature’s 10, a list of people who shaped science in 2025 go.nature.com/4j1uI95
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- Reposted by Amro HussienI wrote a piece for Marginalia Review of Books, based on a talk earlier this year, about the role of narratives in science - something that I think deserves more attention than it gets. www.marginaliareviewofbooks.com/post/theory-...
- Reposted by Amro HussienPeters, @sarawickstrom.bsky.social et al. show that #sphingolipid #metabolism orchestrates establishment of the hair follicle #StemCell compartment. rupress.org/jcb/article/... 📕 From The Year In Cell Biology: rupress.org/jcb/collecti... #CellBio2025
- Reposted by Amro HussienNow online! Membrane potential mediates the cellular response to mechanical pressure
- Reposted by Amro HussienCongratulations to the new cohort of 28 EMBO Young Investigators! They are joining an international network of more than 800 life scientists – Welcome! Read the press release here: embo.org/press-releases/twen…
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- Reposted by Amro HussienAnd here is the story after peer review. This work highlights our current approach, which is to use Piezo channels to uncover new areas of biology that are shaped by mechanical forces: www.science.org/doi/10.1126/...
- New preprint alert! The uterus expands ~500-fold in pregnancy, yet we know little about how pressures are sensed. Led by @yunxiao-dr.bsky.social, we show PIEZOs are required for contractions and birth in mice, with dual roles of PIEZO1 in muscle and PIEZO2 in neurons www.biorxiv.org/content/10.1...
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