Alice Godden
Post-doc in Immler lab at University of East Anglia.
Pop Gen and Evo-Devo
Likes small RNAs, TEs and ⚽️
She/Her
🐠🧬👩💻🐍📊🔬
- ✨Reimagining #Women’s #Health at Norwich Science Festival! Join us on 14 Feb, 10:30–12:00 The Forum, #Norwich for an inspiring conversation with clinicians & researchers 🎟️ Free, booking essential #NorwichScienceFestival #UEAResearch @biouea.bsky.social @theforumnorwich.bsky.social #Menopause
- Reposted by Alice Godden1/6 New preprint! Do changes to insulin/IGF-1 signalling (IIS) that extend lifespan also protect the germline, or do they come with a mutational cost? led by @eduxbury.bsky.social with @alicegodden.bsky.social @immler.bsky.social Johnny de Coriolis Hanne Carlsson www.biorxiv.org/content/10.6...
- Delighted to see our work picked up by @theguardian.com this is a real window of opportunity for us to reduce carbon emissions to give the bears a hope at survival before it really is too late.
- 🐻❄️❄️ New paper alert! From me Ben & @immler.bsky.social “Diverging transposon activity among polar bear sub-populations inhabiting different climate zones” (Godden, Rix & Immler, 2025). 👉 link.springer.com/article/10.1... A thread 🧵. #climate #transposons #TESky #polarbear #ursus @biouea.bsky.social
- > Bears in South-east Greenland in warmer climate more like end of century for other bears > Bears jumping genes more mobile in southern bears > Changes in gene expression linked to health and metabolism
- Also featured in the Guardian: www.theguardian.com/environment/...
- And in the BBC www.bbc.co.uk/news/article...
- 🐟 We’re looking for a zebrafish line similar to Tg(vasa:eGFP) that could potentially be shared with us in the UK. This would greatly support some exciting experiments we have planned. If anyone is able to help or point us in the right direction, we’d be very grateful! 🐟 @zebrafishrock.bsky.social
- Gave a talk at UEA Norwich Med School: “Selfish Elements and Selective Sperm: Impact of Haploid Selection on Zebrafish Fitness.” Part of my broader focus on genomics and fertility/reproduction for all—exploring how genetics shapes reproductive success. Great discussion! @slicescienceuea.bsky.social
- Reposted by Alice GoddenA PhD project on historical genomics in the declining red squirrel in Britain is available in my group, through the @aries-dtp.bsky.social. Use historical genomes to track the effects of decline and genetic rescue in this charismatic species. aries-dtp.ac.uk/studentships...
- 🚨 New preprint alert! Our latest work from @immler.bsky.social lab 🐟🧬 Sex-specific responses of small RNAs and transposable elements to thermal stress in zebrafish germ cells #TESky #TE #piRNA #miRNA #zebrafish #DanioDigest 🔗 Read here www.biorxiv.org/content/10.1... A thread 🧵...
- 1-We tested zebrafish germ cells under elevated temperatures and found sex-specific molecular strategies for survival. 🧬 Genomics 🧪 Transcriptomics 🎯 Small RNAs
- 2- The hot queen effect: ♀ Ovaries = resilient! ✅ Strong miRNA/piRNA defence against transposable elements ✅ Boosted protein-processing pathways ♂ Testes = vulnerable ❌ Reduced piRNA output ❌ More TE insertions + immune signatures
- 3-Why does this matter? Heat stress doesn’t just tweak physiology—it can reshape heritable genomic features, influencing adaptation across generations. www.biorxiv.org/content/10.1...
- Reposted by Alice Godden📢🚨Please share! We’re hiring! 📢🚨Have a strong interests in wildlife ecology and gut microbiome bioinformatics? 3 year Senior Research Associate for NERC Pushing the Frontiers grant. Apply here: vacancies.uea.ac.uk/vacancies/18.... Informal enquiries welcome! drgldavidson.github.io/ACMEresearch
- 🧬 Our latest paper out in Scientific Reports! We explored how Gum Arabic (a dietary fibre) affects the microbiota–gut–brain axis and whole-organism fitness in zebrafish. 🔗 www.nature.com/articles/s41... @immler.bsky.social @biouea.bsky.social What we found ⬇️
- 🐟 Gum Arabic reshaped the gut microbiome (↓ Proteobacteria, ↑ Cetobacterium). 🧠 Changed brain metabolism (↑ acetate at high doses). 🧬 Altered gene expression linked to appetite + energy use.
- And it wasn’t the same for everyone: ♀️ High gum Arabic had negative impacts on female reproductive fitness. ♂️ But in males, effects were mostly beneficial.
- Takeaway: even “simple” dietary fibres can ripple across the microbiota–gut–brain axis — and dosage + sex differences matter. 🐟
- Our new paper is out in Dev Biol! 🎉 🐸🧬 We show #miR-196a directs #neural crest fate in #Xenopus by repressing immature neural #ectoderm — evidence #miRNAs can potentially drive, not just fine-tune, early patterning 👉 Read more here: doi.org/10.1016/j.yd... @devbiol.bsky.social @biouea.bsky.social
- Big thanks to the organisers and chairs for accepting my abstract, this was such a great session to be a part of 🧬🔥🌎🐟
- Now @alicegodden.bsky.social tells us about sex specific activity of TEs, miRNAs and gene expression in the germline under heat stress in zebra fish 🐟
- Reposted by Alice GoddenThanks to all those that attended the @sortee.bsky.social led symposium at #ESEB2025 and for those that met up on Wednesday!! If you’re interested in joining SORTEE and supporting open science in EcoEvo, consider becoming a member! sortee.org/join/
- Reposted by Alice GoddenScreaming into the blue void: anyone out there interested in some long-read #pacbio #european #wolf #sequence data? We have too much data from a pilot to not use, but it is too little data to assemble a #T2T on our own. Open to #collaboration. Get in touch!
- Now on my way to #ESEB2025, Barcelona here we come!
- Reposted by Alice GoddenToday’s the day! Our 2025 Research Colloquium, celebrating the research taking place here in BIO, starts at 09:30 in the Thomas Paine Study Centre. A fantastic day of talks awaits us, including our guest speaker Jean-Baptiste Raina of the University of Technology, Sydney! #UEABioResearch #UEAScience
- Reposted by Alice Godden🔍 From the origins of life to cutting-edge genomic tools, the hashtag#ESEB2025 𝐬𝐜𝐢𝐞𝐧𝐭𝐢𝐟𝐢𝐜 𝐩𝐫𝐨𝐠𝐫𝐚𝐦 𝐢𝐬 𝐚𝐬 𝐛𝐫𝐨𝐚𝐝 𝐚𝐬 𝐢𝐭 𝐢𝐬 𝐛𝐨𝐥𝐝. With more than 50 symposia led by international experts, 𝐭𝐡𝐞𝐫𝐞’𝐬 𝐬𝐨𝐦𝐞𝐭𝐡𝐢𝐧𝐠 𝐟𝐨𝐫 𝐞𝐯𝐞𝐫𝐲 𝐞𝐯𝐨𝐥𝐮𝐭𝐢𝐨𝐧𝐚𝐫𝐲 𝐛𝐢𝐨𝐥𝐨𝐠𝐢𝐬𝐭. 📖 Explore the full list of symposia: 🔗 lnkd.in/da5JU3mv
- Reposted by Alice GoddenRegistered for #EISingleCell25 yet? 🧬 🖥️ We'll be hearing Dr Pascal Barbry, Research Director at the Institute of Molecular and Cellular Pharmacology, about integrating different #singlecell techniques to compare and understand healthy and pathological lung function.
- Reposted by Alice GoddenWith a published genome & advancements in gene editing, the field of #zebrafish genetics has exploded in recent decades. We take a look back at major achievements in this infographic. For more, read this book chapter by @varshneylab.social et al (2015)($) doi.org/10.1016/bs.a... #ZebrafishFunFacts 🧪
- Reposted by Alice Godden🧵 🧪 1/ Female #ReproductiveBiology is, unfortunately, notoriously understudied. So maybe it’s no surprise that a supposedly useless ‘developmental leftover’ in the ovaries could turn out to be...not so useless after all. Meet the rete ovarii 👇 buff.ly/VudxQ2U
- Reposted by Alice GoddenIntroducing the brand new Starter Pack of staff, PhD students and related accounts, from the School of Biological Sciences, UEA. Follow us... #UEAScience go.bsky.app/PLSJXMzat://did:plc:kkkcptqfgpwljqhn6ybmpd2l/app.bsky.graph.starterpack/3lltiwcwc2q2x
- 🔬 My latest work w/ @immler.bsky.social et al: Env. stress alters sperm sRNAs, linking gene expr. + transposons in #zebrafish offspring. @heredityjournal.bsky.social 🧬 Social stress shapes RNA/TE activity across generations #Sperm #miRNA #piRNA #Transposons #TEsky @biouea.bsky.social rdcu.be/eeAwB
- Reposted by Alice GoddenNeed to electroporate and/or live image avian embryos? We hope our new preprint will help you get started: www.biorxiv.org/content/10.1... Open EGGbox: an open-source 3D-printed embryonic Gallus gallus toolbox for electroporation and culture/live imaging of avian embryos ex ovo 🧪🐣 #devbio
- Pleased to share my latest pre-print from my PhD work 🚨MicroRNA miR-196a controls neural crest patterning by repressing immature neural ectoderm programs in Xenopus embryos. 🐸🧬 @biouea.bsky.social #miRNA #Xenopus #neuralcrest #ectoderm #RNA-seq www.biorxiv.org/content/10.1...
- 🚨Our new paper @immler.bsky.social @biouea.bsky.social 🚨 FishPi: a #bioinformatic prediction tool to link #piRNA and #transposable elements Read now in Mobile DNA >> rdcu.be/d7Jub ✅ Covers many species (more to come) ✅ GUI based software #TESky #zebrafish #transposons @zebrafishrock.bsky.social
- Currently has reference files for zebrafish, medaka and tilapia fish. More species can be added. Full instructions provided if you wish to generate your own species input TE and piRNA files for analysis.
- Reposted by Alice GoddenHighlights include new works from @smeetonlab.bsky.social, @alicegodden.bsky.social, @immler.bsky.social & Misty Riddle (#cavefish) 🐟 #WomenInScience
- 🚨New paper from @immler.bsky.social lab Led by Jayme Cohen doi.org/10.1002/pmic... On the #Zebrafish #sperm proteome out now! 🐠
- Reposted by Alice GoddenApplications close Friday (20) for PhD projects as part of the @daniorecode.bsky.social MSCA doctoral network. Project available with Prof Irene Papatheodorou working on comprehensive cell atlases of regeneration in three different species. #zebrafish #singlecell
- Reposted by Alice Godden"Rising temperatures will lead to an increasing number of extinctions, with the highest emission scenario leading to extinction of nearly a third of the Earth’s species, especially those from particular vulnerable taxa or regions." www.science.org/doi/10.1126/...
- 🚨 Happy to share my latest preprint on #polarbear #transposon activity in response to diverging climates in #Greenland #TEsky 🐻❄🌞❄️🧬👩💻
- Diverging transposon activity among polar bear sub-populations inhabiting different climate zones biorxiv.org/content/10.1101/202…
- 🚨Pleased to share our latest preprint on #zebrafish #geneexpression and #transposons in #sperm & #embryos exposed to social stress
- Environmentally induced variation in sperm sRNAs is linked to gene expression and transposable elements in zebrafish offspring biorxiv.org/content/10.1101/202…
- We have just updated FishPi with more functionality- check it out! #TESky
- Home from an amazing #GeneticsSociety transposons meeting.
