Uri Alon
The Alon lab explores design principles of biological circuits, focusing on systems medicine, aging, and healthspan.
- Recommended listening. I was hosted on the podcast “Gil Hameever” to discuss our latest paper about the sudden physiological changes at menopause. The conversation is in Hebrew. open.spotify.com/episode/0EVA...
- We analyzed changes in physiology relative to menopause using two large scale studies that include millions of lab tests. Rather than align by age, we used statistical inference to align tests to final menstrual period. (1/2) arunamed.com/the-menopaus...
- Revealing the dynamical time course of physiological changes before, during and after menopause. This revealed sudden changes at menopause in nearly all physiological systems. (2/2) arxiv.org/abs/2511.05906
- Why does innovative research necessitate a jump into the unknown? Find out (and much more) in episode 147 of רעב לידע עם אור דניאל (Hungry for Knowledge with Or Daniel)! www.learntech.co.il/podcast/pod1...
- Sweet moment in life, our 25th lab anniversary. In a circle, we looked at each other, a group of people with shared values and a soft approach, who want each other to succeed and be happy. (1/2)
- Masterpiece by a masterful scientist Natural Neuroscience by Nachum Ulanovsky @mitpress.bsky.social mitpress.mit.edu/978026204499...
- Our latest on aging, where we reveal an unexpected link between healthspan and equality of lifespans. By @y1fanyang.bsky.social , out now @naturecomms.bsky.social www.nature.com/articles/s41...
- Now in French and Spanish - our pregnancy paper is highlighted also in @lefigaro.fr and @elpais.com sante.lefigaro.fr/medecine/com... elpais.com/salud-y-bien...
- Reposted by Uri Alon[Not loaded yet]
- Reposted by Uri Alon[Not loaded yet]
- "Pregnancy’s true toll on the body: huge birth study paints most detailed picture yet" Our study highlighted in @nature.com News www.nature.com/articles/d41...
- Excited to share our new study revealing the intricate dynamics of pregnancy & postpartum physiology! We analyzed 40M lab tests from 300K pregnancies and 160K women (cross-sectional) and mapped week-by-week changes starting from preconception to months-long postpartum recovery.
- Reposted by Uri Alon[Not loaded yet]
- Theory predicted two kinds of fibrosis, hot and cold. We show in vivo that hot and cold fibrosis describe heart failure, and heart attack, respectively, showing that they are very different disease states. @shovalmiyara.bsky.social @eldadtzahor.bsky.social
- Our work made it to the cover of @cp-cellsystems.bsky.social ! 🥳 Cold and hot fibrosis define clinically distinct cardiac pathologies www.cell.com/cell-systems... Special thanks to Danielle Kimchi for creating this beautiful cover! 🎉 @urialonlab.bsky.social @eldadtzahor.bsky.social
- Sagol lecture in longevity research - Myriam Grunewald on vasculature maintenance for longevity
- Join us at the ICSB in Dublin this October - I will chair the session on aging systems biology icsb2025.com
- Reposted by Uri AlonIt’s finally here! My PhD work, five years in the making, is now published @CellSystems @cellpress.bsky.social 🚨 Cold and hot fibrosis define clinically distinct cardiac pathologies. www.cell.com/cell-systems...
- My brilliant PhD student @Yaelebel.bsky.social gave a talk at the Azrieli Graduate Students forum about her research on using excitable dynamics to explain pulsatile immune phenomena, and how research questions can come from the most unexpected places. Well done Yael! youtu.be/MdwqWx5emo4
- Will be attending the Quantitative Immunology workshop at the Princeton Center for Theoretical Science later month. pcts.princeton.edu/events/2025/...
- Why do cortisol-lowering drugs work for Cushing’s but fail in mood disorders & chronic stress? We propose that the ability of the pituitary and adrenal glands to adjust their functional masses—normally beneficial—counteracts the drug’s effect. Using a math. model, we screened HPA interventions (1/2)
- and found that only targeting CRH can bypass this adaptation and effectively lower cortisol. (2/2) Work by @tomermilo.bsky.social www.embopress.org/doi/full/10....
- Reposted by Uri Alon@urialonlab.bsky.social lab reveals a hormone circuit that explains why most HPA drugs fail for mood disorders and predicts the few that work ➡️ www.embopress.org/doi/full/10....
- Reposted by Uri AlonReally enjoying Uri Alon’s characteristically wonderful lectures on aging: www.weizmann.ac.il/mcb/alon/cou...
