jared toettcher
Dad, bioengineer, climber, skier, surfer (in that order, more or less).
Chaotic good alignment, or so my lab tells me...
- Reposted by jared toettcherToday I'd like to honor the memory of my mentor and friend, Roger Tsien, born 1952 February 1. Today would have been Roger's 74th birthday. Most know Roger for his 2008 Chemistry Nobel Prize with Shimomura and Chalfie. Roger made GFP into the versatile imaging method it is now.
- Reposted by jared toettcherOur new paper just out! pubs.acs.org/doi/10.1021/...
- Reposted by jared toettcherOur research on magneto-sensitive fluorescent proteins and some of their applications has now been published! Huge thank you to the many many people involved in making this happen. 🧪 www.nature.com/articles/s41...
- Reposted by jared toettcherBlog post: Just quit Quitting projects in science is hard, but we should be doing a lot more of it. open.substack.com/pub/arjunraj...
- Reposted by jared toettcherHere's another exciting doctoral project led by Research Group Leader Beatrice Ramm at the Friedrich Miescher Laboratory. Check the list of other available projects on our website: lnkd.in/gEMXNQY6 The application portal is open so apply now! #PhD #IMPRS #graduateprogram #maxplanck
- Reposted by jared toettcherJanelia is hiring! "Invent new imaging methods, molecular tools, or protein chemistry approaches" www.janelia.org/content/lead...
- Reposted by jared toettcherSo happy to announce our new preprint, “A geothermal amoeba sets a new upper temperature limit for eukaryotes.” We cultured a novel amoeba from Lassen Volcanic NP (CA, USA) that divides at 63°C (145°F) 🔥 - a new record for euk growth! #protistsonsky 🧵
- Reposted by jared toettcherThe lab’s first pre-print! We investigated how growth-inducing Erk activity waves are regulated in regenerating zebrafish scales. We discovered that Erk waves are followed by waves of expression of their own inhibitors, as predicted by excitable waves theory. tinyurl.com/26r2cmpj
- Reposted by jared toettcherDomesticated animals have pulled our heavy carts and turned our large mills for centuries. But what about the opposite end of the spectrum—what if the wheel you want to turn is so small you can’t see it? Turns out we can harness the power of bacteria to power the world’s smallest machines. 1/7 ⚛️🧪
- Reposted by jared toettcherGreat Job - Great Colleagues - Great Science👍 Help us pick the next generation of @hhmi.org Investigators, Freeman Hrabowski Scholars, Hanna Gray Fellows, Gilliam Fellows Relocation to DC is required, perfect for academic PIs looking for their next chapter hhmi.wd1.myworkdayjobs.com/External/job...
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- Reposted by jared toettcher🚀 Our new paper is out @natmethods.nature.com! Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells. 🔗 www.nature.com/articles/s41... 🧬 www.addgene.org/John_Ngo/
- Reposted by jared toettcherSCHEPHERD--the bioelectric cell herding platform built for YOU. Single cells, monolayers, organoids--this herds them all + new tricks. Plz try it-- we will *give* you parts! Teaser here of a steering a single cell. GS Yubin Lin's lifeblood with J. Yodh on piano; Celeste R. and Paul K. Thread 1/N
- SCHEPHERD: A universal platform for high-throughput, high-resolution, and programmable control of cell behavior through bioelectric stimulation biorxiv.org/content/10.1101/202…
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- Reposted by jared toettcherVery excited to be co-organizing this meeting next February. Fellow collective behavior enthusiasts, this one is for you!
- ✨ How do bird flocks form or diseases emerge? Join the brand-new EMBO | EMBL Symposium #EESCollectivity and explore how collective behaviours arise from fundamental principles across biological systems 🧬🦠🐒 💻 s.embl.org/ees26-01-bl ✒️ Submit your abstract by 18 Nov
- Reposted by jared toettcherLatest paper elifesciences.org/articles/107... closes an important cycle in our efforts to study regeneration: week-long recordings allow us to observe the behaviour of cells during the entire course of regeneration in a crustacean leg – bright objects in movie are fluorescent nuclei of cells. 1/6
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- And for your Friday afternoon, some in vivo ERK and RTK biosensor eye candy :)
- pYtags - our in vivo biosensors for receptor tyrosine kinases - in all their beauty on the cover of Cell Reports! Read more here: www.cell.com/cell-reports...
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- Reposted by jared toettcherI was explaining to my Ukrainian colleague the phrase ‘There’s no such thing as a free lunch’. She told me the equivalent in Ukrainian is ‘The only free cheese is in the mousetrap’ - which is so much better
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- Reposted by jared toettcherWe built pYtags to detect RTK activity in Drosophila embryos and used them to learn about how developmental patterns form bsky.app/profile/emko...
- Have you ever wanted to *see* receptor activity in embryos? If so, our new preprint is for you! In it, we showcase a new live-cell biosensor for visualizing receptor tyrosine kinase activity in living embryos – pYtags! www.biorxiv.org/content/10.1...
- Reposted by jared toettcherExcited to share that our work building in vivo biosensors for receptor tyrosine kinases (pYtags!) is now out www.cell.com/cell-reports...
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- Reposted by jared toettcherSynthetic biology could enable new types of programmable therapeutics. Our new preprint introduces synthetic protein circuits that selectively trigger cell death in Ras-mutant cancer cells, with interesting advantages compared to existing approaches. www.biorxiv.org/content/10.1...
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- This is a beautiful paper first authored by a (brilliant) Princeton undergrad!
- Nucleoli as biomolecular bubble tea! Congrats to former Princeton ugrad Holly Cheng (now GS @MIT) ->Holly's senior thesis work, a close collab w Roggeveen Wang & @zs-biophys.bsky.social &Stone. Come for the cool movies & stay for the viscoelasticity! www.pnas.org/doi/10.1073/pnas.2407423122
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- Reposted by jared toettcherYesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab
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- I'd like to share a little bit of happy lab news in these chaotic times: a new preprint, driven by the brilliant Qinhao Cao! www.biorxiv.org/content/10.1... We address a big challenge in synbio: If you give me a protein "X", how can I give you a version of X whose activity is controlled by a kinase?
- This problem looks a lot like one we face in optogenetics: Given a protein, can I make a light-switchable version of it? One way to do that is to fuse an "opto-switch" domain to a target protein. Light changes the conformation of the opto-switch, which tugs on the protein to turn it on or off!
- Reposted by jared toettcherOur field has lost an amazing scientist, mentor, and old friend. Benny, along with Mike Hoffman, had a brilliant idea in the early 1980s. The first oncogenes were being cloned and they realized if we wanted to understand their roles in cancer, we needed to understand their normal function 1/n 🧪
- Reposted by jared toettcherUnbelievable. Richard Youle, winner of the Breakthrough Prize for Life Sciences, just got fired from the NIH. If you want to know what madness looks like, here it is, my friend.
- NEW: The doctor behind breakthrough Parkinson’s research was among the scientists purged from the National Institutes of Health, the US’s leading medical research agency. www.wired.com/story/doctor...
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- I'm so happy to report that our preprint on light-induced collective cell migration has now been published in Cell Systems! This project was a lot of fun and will be the basis for a lot of our ongoing & future work.
- I was also touched to see a Highlight piece on the work by Romane Petit & Leo Valon - thank you for featuring the work! www.cell.com/cell-systems...
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- Reposted by jared toettcherMaking intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15) www.biorxiv.org/content/10.1...
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- Reposted by jared toettcherAnnouncing this upcoming conference: GASTRULATION RELOADED: Developing, engineering, and evolving the body plan Join us as we explore the latest research on gastrulation and axis formation/elongation, featuring common, exotic, and synthetic embryos! 📅 14–17 October 2025 📍 Paris, France
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- Reposted by jared toettcherSuper excited to finally share PANCS-Binders: our group's decade-long quest to accelerate protein binder discovery. TLDR: PANCS-binders is fast (2 days), cheap (pennies), has extremely high fidelity (low false positive and negatives), and high-throughput. 1/n
- Read below for the latest from Emily Ho in my lab on in vivo receptor tyrosine kinase biosensors. This has been a *dream* project, seeing endogenous RTK activity in live embryos for the first time. Surprise: they don't always match those of downstream signaling pathways!
- Have you ever wanted to *see* receptor activity in embryos? If so, our new preprint is for you! In it, we showcase a new live-cell biosensor for visualizing receptor tyrosine kinase activity in living embryos – pYtags! www.biorxiv.org/content/10.1...
- Reposted by jared toettcherHave you ever wanted to *see* receptor activity in embryos? If so, our new preprint is for you! In it, we showcase a new live-cell biosensor for visualizing receptor tyrosine kinase activity in living embryos – pYtags! www.biorxiv.org/content/10.1...
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- Reposted by jared toettcher1. I feel like this is such obvious advice that it gets taken for granted & consequently no one says this to young scientists but READ PAPERS, read all the papers. As you move up in your career you will have less & less time to do this. Read everything that appeals to you not just in your field
