Bryan Bryson
Tuberculosis, systems immunology, innate immunity, vaccines, computational biology. brysonlab.org
- Friends in the de novo binder protein design space -- if you've designed binders against cell surface proteins and then used them as flow cytometry reagents, I'd love to chat and compare notes!
- Two pieces of fun news: 1. We've launched a new website for our lab: www.brysonlab.org 2. With some new funding, we are recruiting for new postdocs and graduate students. The projects build upon our previous studies of antigen presentation and phagosome biology and go into new exciting dimensions!
- For postdoc candidates, please email me a CV and a cover letter. For graduate students, y'all know the processes for your appropriate departments and if you're not a graduate student yet, start getting your applications ready for next year's cycle!
- The @ragoninstitute.bsky.social is launching a new faculty search for a computational immunologist! Applications are open now and reviewed on a rolling basis. Please share broadly with your networks! #immunosky www.nature.com/naturecareer...
- Happy to share our newest preprint on antigen presentation of Mtb-derived peptides on MHC-I: www.biorxiv.org/cgi/content/... This is a follow up to our previous paper where we applied immunopeptidomics to understand MHC-I presentation by Mtb-infected cells: elifesciences.org/articles/84070
- Excited to share our lab's newest preprint (strap in if you're excited about metabolism, species differences, or Mtb gene expression): www.biorxiv.org/content/10.1...
- Excited to share our newest manuscript on antigen discovery and vaccine design for tuberculosis lead by Owen Leddy (everyone hiring new faculty in a few years, remember this name!) www.science.org/doi/10.1126/... #TBsky
- Congrats to the Carpenter Lab on this exciting study! I might now sound like a broken record, but check the abstract!!! Let’s go type 7 secretion system substrates! #tuberculosis #tbsky
- Happy to see more data pointing to an important role for type 7 secretion substrates in TB protective immunity
- Reposted by Bryan Bryson[Not loaded yet]
- Newest paper from the lab out today (doi.org/10.1084/jem....)! Here, we describe PathMHC, a novel MS-based approach to identify rare pathogen-derived peptides on MHC-I and MHC-II. We apply this to a range of pathogens Mtb, SARS-CoV-2, and Listeria.
- Anyone have experience with IV mRNA-LNP vaccination in animals? I am specifically interested in LNP formulations and what the preferred formulation for IV is.
- Pictured: glass of champagne I treated myself to at DCA upon learning the lab has been tenured! Grateful to my lab family, my extended science family, and my family for the amazing support and love offered on the journey so far. Much more work left to do but taking this moment to say thank you!
- Does anyone know of a CRO that produces MVA-based vaccines?
- Do any of my #tbsky friends have interests in T cell responses in people with evidence of prior Mtb infection? If so, would you have any interest in looking at T cell responses to Mtb-derived peptides that we have detected by mass spectrometry? LMK 🙏🏽
- Reposted by Bryan Bryson[Not loaded yet]
- Does anyone have a favorite protocol for in vitro priming of human T cells from PBMCs? #immunosky
- So glad to see this out! I learned a lot in this project about how to think creatively about customizing our approach to using language models for immune receptors
- Immunopeptidomics (impep) friends, have you ever done impep to ID peptides after soluble protein delivery to phagocytes to look at peptides generated by XP?
- Before I write my own analysis script, does anyone in #tbsky have a tool for pathway analysis for Mtb genes?
- A lovely day to celebrate the amazing people I work with every day
