- 🚨Publication alert! 🚨 Why does stress drive psychopathology & transdiagnostic disease? We present the Allostatic Triage Model of Psychopathology (ATP Model), which explains stress-induced transdiagnostic disease pathogenesis through a bioenergetic lens. www.sciencedirect.com/science/arti...Oct 20, 2025 15:59
- In the ATP Model, we introduce a novel concept- Allostatic Triage: the stress-induced reallocation of CNS metabolic resources from expensive executive control networks that optimize long term outcomes to less expensive networks optimized for short-term survival, like the salience network
- Stress is metabolically expensive & all biology depends on finite energy resources, especially the CNS, which is the most expensive tissue in the body and has limited access to metabolic resources.
- What happens when the brain cannot generate enough energy to handle stress?
- We propose that metabolic stress drives allostatic triage to stress-responsive networks that ensure short-term survival, like the salience network, from other networks including the central executive network that supports executive and goal-oriented functions, driving psychiatric symptoms
- Altogether, we propose that extreme or chronic stress dysregulates mitochondria, affect, and allostatic triage, impairing allostasis, and driving transdiagnostic pathological states that, over time, become entrenched or "canalized" into pathological transdiagnostic disease phenotypes.
- So many thanks to all of my mentors & co-authors for making this possible: @martinpicardenergy.bsky.social @thethrivelab.bsky.social @trpr-ucsf.bsky.social @parkersingleton.bsky.social @curiouslykaty.bsky.social, Gabriel Sturm, Ellen R. Bradley, Thomas Neylan, and Joseph Francis
