D. Parker Kelley, PhD
Data Science Fellow in Trauma and PTSD @ UCSF & SFVAHCS
Mitochondrial psychobiology, psychoneuroimmunology, stress, PTSD, and psychedelics
This must be the place
- Reposted by D. Parker Kelley, PhD𝗛𝗼𝘄 𝗱𝗼 𝗯𝗿𝗮𝗶𝗻 𝗮𝗿𝗲𝗮𝘀 𝗿𝗲𝗹𝗮𝘁𝗲𝗱 𝘁𝗼 𝗳𝘂𝗻𝗰𝘁𝗶𝗼𝗻? "High-resolution activity maps of PFC did NOT align with cytoarchitecturally defined subregions." Key tenet in neuroscience is that cytoarchitectonic boundaries correspond to functional ones. NB: study in the mouse #neuroskyence doi.org/10.1038/s415...
- Please use full factorial designs in preclinical psychedelic research! I'm guilty of not doing so in the past, but it will be critical for understanding their MOA going forward. We need to be able to directly compare effects in pathology to those healthy organisms
- Reposted by D. Parker Kelley, PhDExcellent interview... VERY interesting insights on stress vs mitochodrial energy balance. I wonder how much impact on stress adaptation can be gained by increasing mitochondrial resilience w keto/low carb/ Fasting and the right amount of Exercise stress (hiit, resistance trng)
- I had a fantastic discussion about our Allostatic Triage Model of Psychopathology (ATP Model) and the potential mitochondrial and metabolic effects of psychedelics with @metabolicmind.bsky.social Thanks so much for having me on! Check er out: youtu.be/-e49-DwCZ9A?...
- Congrats @carmensandi10.bsky.social !!
- Warm congratulations to @carmensandi10.bsky.social for winning the Mika Salpeter award. Incredibly well-deserved as I know of few other stellar neuroscientists who have advanced the careers of women in the field
- Reposted by D. Parker Kelley, PhDMetabolism is an energetic circuitry that transcends cellular and organellar boundaries www.nature.com/articles/s42...
- Wait so midazolam is an antidepressant? Wut?
- New 6-month depression RCT in n=65, serial Ketamine infusions as adjunctive care vs active placebo midazolam. Ketamine did not outperform primary nor any of the secondary efficacy, cognitive, economic, or quality-of-life outcomes. 🧪 #psychiary #PsychSciSky jamanetwork.com/journals/jam...
- Reposted by D. Parker Kelley, PhDHot off the press!
- 🚨Publication alert! 🚨 Why does stress drive psychopathology & transdiagnostic disease? We present the Allostatic Triage Model of Psychopathology (ATP Model), which explains stress-induced transdiagnostic disease pathogenesis through a bioenergetic lens. www.sciencedirect.com/science/arti...
- 🚨Publication alert! 🚨 Why does stress drive psychopathology & transdiagnostic disease? We present the Allostatic Triage Model of Psychopathology (ATP Model), which explains stress-induced transdiagnostic disease pathogenesis through a bioenergetic lens. www.sciencedirect.com/science/arti...
- So many thanks to all of my mentors & co-authors for making this possible: @martinpicardenergy.bsky.social @thethrivelab.bsky.social @trpr-ucsf.bsky.social @parkersingleton.bsky.social @curiouslykaty.bsky.social, Gabriel Sturm, Ellen R. Bradley, Thomas Neylan, and Joseph Francis
- Reposted by D. Parker Kelley, PhDThe way we feel and the psychiatric symptoms some of us end up experiencing could emerge from the way energy flows, or fails to flow smoothly, in mitochondria. The ATP model (Allostatic Triage in Psychopathology) by Parker Kelley @sequencemyneuro.bsky.social www.sciencedirect.com/science/arti...
- Reposted by D. Parker Kelley, PhDPα+ Psychedelic Bulletin #207 - Lykos Rebrands to Resilient - Pharma Pushes Back on Norway’s Ketamine Reimbursement Decision - AbbVie-Gilgamesh Deal Viewed as Validation - Psilocybin Rescheduling Petition Heads to HHS - Much, much more... psychedelicalpha.com/news/p%ce%b1...
- Reposted by D. Parker Kelley, PhDI'm near certain sLFOs are big for psychedelics.
- An exciting 🆕 extension of our sLFO/FC inflation work (www.nature.com/articles/s41...) Extracting the sLFO signal from BOLD data not only sharpens FC estimates.. ..the sLFO itself - via links to arousal - captures variability in trait + state drug use phenotypes: tinyurl.com/msanmrnc #neuroimaging
- Reposted by D. Parker Kelley, PhDJust delighted to see this out in the world !! This is the first installment of SYPRES -- our living meta-analysis + open data resource focused on psychedelics. Led by the incomparable @parkersingleton.bsky.social and @bsevchik.bsky.social. Check it out + and give us your feedback!!!
- 🍄 Our new living systematic review and meta-analysis on psilocybin for depression is out. Here's what we found and the open science infrastructure we built to support it 🧪🧵 www.medrxiv.org/content/10.1...
- Reposted by D. Parker Kelley, PhDIt is impossible to explain to civilians how it feels to finally, FINALLY, land a clearly within-payline NIH grant score and then have it go unfunded because of all this regime bullshit. You all have my sympathies. Unfair doesn’t even begin to describe it.
- Reposted by D. Parker Kelley, PhD🍄 Our new living systematic review and meta-analysis on psilocybin for depression is out. Here's what we found and the open science infrastructure we built to support it 🧪🧵 www.medrxiv.org/content/10.1...
- Such a beautiful project! This is the exact sort of framework we need to advance progress going forward.
- 🍄 Our new living systematic review and meta-analysis on psilocybin for depression is out. Here's what we found and the open science infrastructure we built to support it 🧪🧵 www.medrxiv.org/content/10.1...
- Reposted by D. Parker Kelley, PhDDispatch: The Neurobiology of Psychedelics Gordon Research Conference — Circuitry, Consciousness, and Clinical Horizons (Part 2) Reporting by @jasteralaina.bsky.social. The entire Dispatch is now free to read. psychedelicalpha.com/news/dispatc...
- Reposted by D. Parker Kelley, PhDSince its founding in 2021 by myself and Zarmeen Zahid as Your Brain on Science, it's expanded into Psychedelic Brain Science, to encompass the larger goal of including all things psychedelic including research, policy and culture. Now we’re expanding further to provide services! Check it out!
- Reposted by D. Parker Kelley, PhDI’m elated to share our latest publication - out now in @natmentalhealth.nature.com! www.nature.com/articles/s44... - tour de force by @leahbanellis.bsky.social @brainandstomach.bsky.social and the rest of the VMP team!
- Reposted by D. Parker Kelley, PhDCheck out my keynote & Day 1 dispatch of #GRCPsychedelics 🧠 via @psychedelicalpha.bsky.social psychedelicalpha.com/news/dispatc...
- Reposted by D. Parker Kelley, PhDHad a blast at the first ever #GRCPsychedelics - thanks so much to Chairs @alexkwan.bsky.social @vyazovskiy.bsky.social & Vice Chairs @melissaherman.bsky.social @viditavaidya.bsky.social for bringing our community together 🫶 Per usual, I took no pics - but luckily Missy had it covered for me 😂
- Reposted by D. Parker Kelley, PhDAttending the first psychedelic GRC organized by @alexkwan.bsky.social & @vyazovskiy.bsky.social was surreal. The internationally representative panels ensure we are collectively/efficiently advancing our understanding of psychedelics. Special thanks to @mayoonthebrain.bsky.social for bringing me ❤️
- Reposted by D. Parker Kelley, PhDBring out the dancing lobsters 🦞🕺 #GRCPsychedelics @sequencemyneuro.bsky.social @fredbarrettphd.bsky.social @tanner-anderson.bsky.social
- Reposted by D. Parker Kelley, PhDEveryone approves of the dinner to end the #GRCPsychedelics 🦞 @deffinger.bsky.social @jasteralaina.bsky.social @sequencemyneuro.bsky.social @veronicachelu.bsky.social and Erin Neyhart
- Obviously the mitochondria is the best organelle. 1 can leave cell, but stays 2 own genome 3 regulates nuclear gene expression 4 can kill whole cell 5 makes energy, distributes it to orchestrate cellular processes 6 controls whole organisms behavior 7 makes (sex, growth, stress, etc) steroids
- "Obviously, the nucleus is the best organelle." Shots fired in the #OrganelleWars... I thought everyone was on a ceasefire ✌️
- Reposted by D. Parker Kelley, PhDScience together climb together - sneaked out with fellow #GRCPsychedelics attendees for a quick session 💪
- Reposted by D. Parker Kelley, PhDGreat panel this morning on the human and clinical studies of psychedelics - my impression is we have come a long way in the last few years in terms of design and quantification #GRCPsychedelics
- Reposted by D. Parker Kelley, PhD
- Reposted by D. Parker Kelley, PhD🌈🧠 The Trip Between Bedside and Bench 🌈🧠 Join us at #SfN2025 for a deep dive into cross-species research in psychedelic neuroscience! 🧬 Posters, 🎤 panels, 🔑 keynotes, 🍸 cocktails, and 🥟 tasty apps await. RSVP, explore speaker profiles, and help spread the word: 👉 hopkinspsychedelic.org/sfn2025
- Reposted by D. Parker Kelley, PhDI had a great time at #GCRpsychedelics, discussing our data on the non-hallucinogenic derivative of LSD, alongside a stellar panel of researchers! Very grateful to @alexkwan.bsky.social and @vladvysotsky.bsky.social for inviting me and putting together a very exciting program!
- Reposted by D. Parker Kelley, PhDThank you #NIMH #NIDA and #BrainInitiative for an informal panel at the #GRCPsychedelics to answer questions regarding grant funding. 🙏
- Reposted by D. Parker Kelley, PhDPoster session in full swing. Lots of exciting unpublished work. #GRCPsychedelics
- Reposted by D. Parker Kelley, PhDGoing to open an escape room where hippocampus researchers have to solve riddles without using space as an explanation for everything
- Psilocybin only enhances fear extinction when its hippocampus-dependent (trace/context), and only in a sub-population of mice. Anybody have an explanation? I’ve got ideas, but curious what other are thinking about this ? www.nature.com/articles/s41...
- Reposted by D. Parker Kelley, PhDThis is from The Tonight Show with Johnny Carson aired on May 20th, 1977. Carl Sagan says something very important, a strong message that didn't lose any validity since then.
- Wowzers, a peripheral mitokine,GDF-15 mediates anxiety behavior caused by restraint stress through the GFRAL receptor in the brain stem! “Anxiety-like behaviour elicited by adrenaline or restraint stress is eliminated in mice lacking the GDF15 receptor GFRAL” www.nature.com/articles/s42...
- Incredibly grateful to have had the opportunity to visit the Shulgin lab last weekend. Sasha Shulgin discovered the empathogenic properties of MDMA and first synthesized DOI, an important tool for psychedelic research, among myriad other important compounds.
- I was so proud to rock my Mitochondrial Psychobiology sweatshirt to this event and discuss the effects of psychedelics on systemic bioenergetics with everyone!
- Reposted by D. Parker Kelley, PhD' this study provides evidence of a dementia-preventing or dementia-delaying effect from zoster vaccination ' www.nature.com/articles/s41...
- Fascinating! Do we think this vaccine is cross reacting with another virus that contributes to dementia, or that this is explained by other off target effects unrelated to viral pathogens?
- The vaccine against Shingles helps protect against dementia, results of a natural experiment, adding to prior evidence "implications are profound" New @nature.com www.nature.com/articles/d41... nature.com/articles/s41...
- Yuge paper! Long awaited CryoEM structures for seven psychedelics.
- Congrats to all —essential reading for those interested in #psychedelics www.nature.com/articles/s41...
- Reposted by D. Parker Kelley, PhDI'm not sure that our study necessarily implies that one should not average trials - averaging will always have its place. However, our results do show that there is substantial and meaningful variability across trials that is lost when averaging. #neuroscience #neuroskyence
- Averaging brain responses is not a great idea... #neuroscience #neuroskyence www.nature.com/articles/s41...
- Reposted by D. Parker Kelley, PhDWe’ve launched a new clinical trial exploring the efficacy of psilocybin therapy for anorexia nervosa in young adults (age 18 to 25)! Learn more at tiny.ucsf.edu/HTkr9L or take our pre-screen survey to see if you’re a good fit tiny.ucsf.edu/gmvCA3.
- This is so cool! Love to see it
- Can whole-brain imaging of cellular c-Fos signals be used to classify #psychedelics? 🧠🔬💊 Our study by @aboharbf.bsky.social and @pashadavoudian.bsky.social, developing an imaging and machine learning pipeline to test a panel of psychoactive drugs. Paper here 👇 www.nature.com/articles/s41...
- Super cool work showing that pleiotropic genes increase trans-diagnostic risk for multiple categories of psychiatric disorders! www.cell.com/cell/abstrac...
- Of all known technologies, I am most excited about Raman Spectroscopy. Its the closest thing to the Star Treck Tricorder that I'm aware of. Lasers wiggle molecules, and you measure the wiggles to know what it is. Imagine a world where we can scan just about anything and determine its composition?
- Taking non-invasive glucose tracking to the next level, using Raman spectroscopy, without any needles www.nature.com/articles/s42...
- Reposted by D. Parker Kelley, PhDReminder: You can always submit a grant late and include a cover letter saying why. NIH receipt and referral may take it. Or not. If you end up missing deadline because of these Commons access issues, there is this potential save move.
- Reposted by D. Parker Kelley, PhDI’ll be speaking at the upcoming International Society of Research on Psychedelics (ISRP) virtual conference on March 7, 2025! 🌐 ✨ 24 presentations from psychedelic researchers. ✨ Cutting-edge insights in psychedelic science. ✨ Register here today! #Psychedelics #PsychedelicResearch #ISRP2025
- Reposted by D. Parker Kelley, PhDOpen to all interested in psychedelics, the upcoming virtual ISRP meeting! Register now and catch up on the latest breakthroughs!
- Today is the last day for early bird registration for @ISRPsychedelics! Are psychedelics anti-inflammatory? Come to my talk to find out what we know.
- Are psychedelics anti-inflammatory? A systematic review and meta-analysis of studies examining the immunomodulatory effects of serotonergic psychedelics Come see me present at the International Society for Research on Psychedelics on March 7th! (online) www.isrpsych.org/conferences
- Would love to chat about this with some bioethicists sometime! It’s a very interesting and unfortunately touchy topic that we really need to discuss out in the open! #bioethics @trpr-ucsf.bsky.social
- Will be of interest to folks following #bioethics skeets
- Home of the?
- Reposted by D. Parker Kelley, PhDThe (concise) core of my critique of MAPS/Lykos' MDMA-assisted therapy model is now published as a bioethics commentary in AJOB, titled "Focused Bodywork as Facilitated Communication: Cautionary Perspectives on Touch in Psychedelic Therapy": www.tandfonline.com/doi/full/10....
- Reposted by D. Parker Kelley, PhD🚨 Save the Date! 🚨 I'm speaking about 4-HO-MiPT analogs at the upcoming International Society of Research on Psychedelics (ISRP) virtual conference on March 7, 2025! 🌐 ✨ 24 presentations ✨ Register here today - www.isrpsych.org/store #Psychedelics #PsychedelicResearch #ISRP2025
- Reposted by D. Parker Kelley, PhDHow the brain gets rid of its chemical waste through the glymphatics during sleep, via blood vessel oscillations, regulated by norepinephrine. Impeded by Ambien! www.cell.com/cell/abstrac... www.science.org/content/arti...
- Big co-1st/corresponding author paper just published in @JAMAPsychiatry! I just can't thank our team enough for their unwavering support on this project. Modifying Informed Consent to Help Address Functional Unmasking in Psychedelic Clinical Trials jamanetwork.com/journals/jam...
- Effects of psilocybin in mice depend on context of administration! Psilocybin [5 mg/kg (> 5-10x higher than human dose)] has anxiolytic effects in male and female mice, which were ameliorated (m) or attenuated (f) by concurrent restraint stress. www.sciencedirect.com/science/arti...
- Woah.. surprised to see this, but obviously it should be addressed in our public health policies.. my understanding is that topical fluoride on the teeth is highly effective at reducing cavities, but systemic fluoride is less useful in that way.. so keep it in toothpaste, but not water?
- Is fluoride exposure associated with lower IQ scores in children? jamanetwork.com/journals/jam... A new systematic review of 74 studies says yes.
