Schuller Jan
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- Reposted by Schuller JanLast Friday was the defense of my PhD thesis entitled "Structural basis of anaerobic enzymes mediated by noncanonical metalloclusters" after 4 yrs at the @synmikro.bsky.social 🎓🎓 Big thanks to my supervisor @schullerjm.bsky.social and the whole Schuller lab for their continuous and massive support!
- The largest challenge of the day. Try to assemble 5 structural biology papers (each more than 100 pages incl. Supplements) in a single pdf with less than 15MB to upload as a document for a prize nomination for a student. Not sure compression algorithms are that good...
- Reposted by Schuller Jan📢 Postdoc position: Cell Biology of Cyanobacteria in my group, as part of the Excellence Cluster "Microbes for Climate" (M4C) in Marburg, Germany. More information at shorturl.at/wNnDT (see Project 2) 🔗Apply at shorturl.at/VsEDl 📅Deadline: Nov 16, 2025 Please repost. #Postdoc
- Reposted by Schuller JanA new preprint from the lab. I won't do a tweetorial until this is peer reviewed, but I think it's a banger, led by @JedNzy. It's about Rubisco and what chaperones are really for. He's on the market, get him while you can. www.biorxiv.org/content/10.1...
- Reposted by Schuller JanDie aller♥️lichsten Glückwünsche🍾🥂auch von uns an Jan Schuller, Wissenschaftler👨🏼🔬bei LOEWE-Tree-M & zuvor bereits beim ehem. LOEWE-Zentrum SYNMIKRO, zu seinem #Explorationsstipendium der Boehringer Ingelheim Stiftung! @synmikro.bsky.social @loewe-tree-m.bsky.social.
- Dr. Jan Schuller erhält renommiertes Boehringer Ingelheim Stiftung (BIS) Stipendium. Im Fokus: Wie schädliche #Darmbakterien ohne #Sauerstoff Energie gewinnen – die Funktionsweise von #Clostridioides difficile uni-marburg.de/eOYjSV Foto: R K Wegst #Mikrobiologie #Kryo-Elektronenmikroskopie
- Reposted by Schuller Jan‼️ Exciting new preprint from a close collaboration with Kylie Walters' group. Our study maps the binding sites of key regulators of the proteasome in situ. www.biorxiv.org/content/10.1...
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- Reposted by Schuller Jan#PhDposition #OrganicChemistry #ChemBio - deadline 03.08 - please RT ❤️ Application online stellenangebote.uni-marburg.de/jobposting/d...
- Reposted by Schuller JanFinally online! Our latest research is out @nature.com: We show that non-antibiotic drugs can disrupt colonization resistance, raising the risk of enteric infections. rdcu.be/ewwrG
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- Proud to present the lab's latest work. The full structure of the sodium translocating methyltransferase (Mtr) bound to a small oxygen-responsive small protein MtrI. Work by Tristan and together with @schmitzstreitslab.bsky.social . www.biorxiv.org/content/10.1101/2025.06.02.657420v1
- This is a showcase study how small ORF proteins can regulate a central bioenergetic machinery. MtrI, binds here in a oxygen sensitive manner to the methyltransferase shuttle domain of MtrA.
- Reposted by Schuller JanOur structural core gene pipeline Unicode is now published at GBE 📄 doi.org/10.1093/gbe/... Please also check out @dongwookkim.bsky.social’s 🧵 bsky.app/profile/dong...
- Unicore identifies single-copy protein structures across genomes using Foldseek, bypassing slow structure predictions by utilizing 3Di predictions from ProstT5, enabling rapid phylogenetic inference at the tree-of-life scale. 1/n 📄 www.biorxiv.org/content/10.1... 💾 github.com/steineggerla...
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- Reposted by Schuller JanArchaea xkcd.com/3095/
- Reposted by Schuller JanHere is one big reason to choose Europe to advance with your research career: We 💙 science.
- Reposted by Schuller JanWant to try LocScale-2.0 without installing locally? Check out ColabScale: just upload your maps or enter your favourite EMDB ID and run LocScale-2.0 in the cloud. edu.nl/ur3ge
- Reposted by Schuller Jan🎉Doppelerfolg für die #UniMarburg in der Exzellenzstrategie! 🎉 Zwei Cluster zu Klimawandel und menschlicher Wahrnehmung sichern sich Förderung. Marburg beweist Forschungsstärke und Innovationskraft.🚀 @proloewe.bsky.social @synmikro.bsky.social @maxplanck.de @jlugiessen.bsky.social @tuda.bsky.social
- Reposted by Schuller Jan📢 Wir sind stolz und freuen uns, dass unser Exzellenzcluster Microbes-for-Climate (M4C) in der Exzellenzstrategie 2025 ausgewählt wurde! 🌟Wir freuen uns gemeinsam mit @unimarburg.bsky.social auf spannende #Mikrobenforschung - stay tuned ! @unimarburg.bsky.social @maxplanck.de @synmikro.bsky.social
- Reposted by Schuller JanPleased to share my very general review of Photosynthesis now published in Nature Reviews Mol Cell Biol 🌞🌱 rdcu.be/em1lz Hopefully a useful primer for Postgrad and undergrad students
- Reposted by Schuller JanEtfD links beta oxidation to OxPhos in mycobacteria - recent work suggests that targeting EtfD could shorten #tubeculosis treatment. But how does EtfD work? And how can you assay its activity? In his final PhD manuscript @courbongautier.bsky.social provides answers! www.biorxiv.org/content/10.1...
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- Reposted by Schuller JanWe've updated our AFESM website to now include biome filtering, allowing exploration of protein structures adapted to specific environments. 🌐 afesm.foldseek.com Read more about the work in the skeetorial 🦋 bsky.app/profile/mart... or our preprint 📄 www.biorxiv.org/content/10.1...
- AFESM: a metagenomic guide through the protein structure universe! We clustered 821M structures (AFDB&ESMatlas) into 5.12M groups; revealing biome-specific groups, only 1 new fold even after AlphaFold2 re-prediction & many novel domain combos. 🧵 🌐 afesm.foldseek.com 📄 www.biorxiv.org/content/10.1...
- Reposted by Schuller Jan🌱 Excited to share that I will start my lab at EPFL, CH this June supported by a @snsf.ch Starting Grant! ramakrishna.ch We are interested in plant mineral nutrition and will deep-dive into the fine-tuned mechanisms employed by plants to adapt to abiotic stresses such as salinity. #newPI #plantsci
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- Incredible work to understand CO adaption by an highly unusual mechanism in one of our favourite anaerobes. www.nature.com/articles/s41...
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- Reposted by Schuller JanInteresting thread 🧵 from @georghochberg.bsky.social dissecting the evolution of nitrogenases from cofactors of methane-producing enzymes. The “molecular paleontology” possible with modern technology is so cool. 🧪🧶🧬
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- Happy to present the lab latest work, today from the green-side. The ultimate PSII assembly intermediate that directly precedes incorporation of the Mn4O5Ca cluster and formation of the OEC. Psb32 binds to PsbV, challenging the assumption the extrinsic subunits all associate spontaneously in-vivo.
- The SchullerLab will also go the preprint route now, for most of our stories. Thanks to good friends, who always advocate and set great examples. @cellarchlab.com yes, I am talking about you guys. www.biorxiv.org/content/10.1...
- Reposted by Schuller Jan“The Website” is here! It can be intimidating getting into analysis of #CryoET data, and software is evolving all the time👩💻🚀. @phaips.vd.st & @florentwaltz.bsky.social put our lab’s workflows into an online guide. We hope this helps lower the bar to joining #TeamTomo. Feedback much appreciated! 🧪🧶🧬🔬
- Hey #TeamTomo, Ever been in need of a tutorial about the fundamentals of cryo-electron tomography? From preprocessing raw frames to high-res subtomogram averaging? That's why @florentwaltz.bsky.social and I made this website! tomoguide.github.io Follow the thread 1 /🧵 #CryoET #CryoEM 🔬🧪
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- Reposted by Schuller JanYou want to start tomography? Solve structures inside cells? Reach Nyquist 😳 ? @phaips.vd.st and I have a website for you! tomoguide.github.io You'll find a tutorial on how to reconstruct tomograms, pick particles and do subtomogram averaging, using different software! Hope it will be useful !
- Hey #TeamTomo, Ever been in need of a tutorial about the fundamentals of cryo-electron tomography? From preprocessing raw frames to high-res subtomogram averaging? That's why @florentwaltz.bsky.social and I made this website! tomoguide.github.io Follow the thread 1 /🧵 #CryoET #CryoEM 🔬🧪
- This 🧵 about the evolutionary implications by my good friend Georg the mastermind behind evolutionary analysis and understanding is a must read for everyone who wants to know how methanogenesis and N2 fixation are evolutionary connected. It's quite an evolutionary bomb.
- Reposted by Schuller JanThis is a wild paper. The anaerobic biochemistry is definitely worth your while (and beyond me to explain), but let me try to explain why this is also an evolutionary bombshell. This is about how nitrogen fixation evolved as we know it.
- I'm truly excited to announce our new publication in @nature.com unraveling a central picture of the Methyl-coenzyme M reductase (MCR) activation machinery and it's strong ATP dependency - kudos to @rnfr2d2.bsky.social for the fantastic illustration! LINK: www.nature.com/articles/s41...
- Reposted by Schuller JanHere's what my former employer @tuberlin.bsky.social wrote about our work (🇩🇪) www.tu.berlin/news/pressem...
- Reposted by Schuller JanUnser Heisenberg-finanzierter Arbeitsgruppenleiter Dr. Sven Stripp (links hinten) hat in Zusammenarbeit mit Kolleg*innen der @unimarburg.bsky.social einen Artikel in @nature.com publiziert. Die @unipotsdam.bsky.social berichtet: www.uni-potsdam.de/de/nachricht...
- One of the largest open questions in anaerobic metabolism solved. The best work of my lab yet, performed by the incredible hard working, talented and motivated coworkers: @fidelormz.bsky.social , @sophia-pa.bsky.social and @rnfr2d2.bsky.social. I am a proud PI today! www.nature.com/articles/s41...
- Do you want to join the team? I just got awarded a 2 year fully funded Postdoc position to investigate the metabolism of anaerobic pathogenic bacteria. If you have a strong background in protein biochemistry or anaerobes shown by solid publications, reach out. Job add follows, please repost.
- Reposted by Schuller JanI am incredibly excited to share my first-ever research paper that has just been published in Nature! I thank my fellow co-first authors @fidelormz.bsky.social and @rnfr2d2.bsky.social and @schullerjm.bsky.social for leading this project. www.nature.com/articles/s41...
- Reposted by Schuller JanFor decades, how methanogenic archaea activate the MCR complex to produce methane remained a mystery. Today in Nature, we report the high-resolution cryo-EM structure of the MCR activation complex! www.nature.com/articles/s41...
