sambooker
- We just published a thing! www.frontiersin.org/journals/pha... Here we show that somatostatin interneurons display exaggerated LTP in a mouse model of Fragile X Syndrome, and which is sensitive to GABAB receptor activation; but which are not manifested at the circuit level - more work to do!
- This raises the interesting question of how many single-cell phenotypes in this model are effectively compensated for to maintain network fidelity....
- Reposted by sambooker[Not loaded yet]
- www.biorxiv.org/content/10.1... super excited to release this. nearly 7 years ago, we set out to investigate whether FMRP regulates excitability of neurons in living human brain tissue. we find loss of FMRP in adult neurons leads to elevated excitability, corrected by PDE4D inhibition.
- This work has been championed by Max Knops and @sorayam.bsky.social, and many other colleagues, not limited to: Max Wilson, @bonthronphd.bsky.social @l-w-taylor.bsky.social Alsadeg Bilal, Imran Liaquat, Paul Brennan, @clairedurrant1.bsky.social
- Hello world! We just released a thing! In this preprint we provide evidence questioning the ability of the axon initial segment to undergo rapid structural plasticity in intact neurons from mouse, rat, and human cortex.
- Reposted by sambookerMeet the Simons Initiative for the Developing Brain: a center devoted to deconstructing the secrets of neurodevelopmental disorders and the developing brain. Read more: annualreports.simonsfoundation.org/2024/scottis... #science #neuroscience
- What, what! We just published our work studying GABAB receptors in human and rat brain. www.nature.com/articles/s41...
- Reposted by sambooker[Not loaded yet]
