Simon J. Clark
Helmut Ecker Endowed Professor of AMD & Co-Founder - Complement Therapeutics. Interested in ocular immunology and health. A British Biochemist in Europe 🇬🇧 🇪🇺
#ExtracellularMatrix #complement #ophthalmology
tinyurl.com/Clark-lab
- Study of 156 dengue patients shows distinct complement signatures by disease severity, with soluble CR1 emerging as an independent early predictor of severe outcomes. #Dengue #Immunology #ComplementSystem #Biomarkers #GlobalHealth #Science buff.ly/da4fIQb
- New study links gut microbiome function, not composition, to complement dysregulation and genetic risk in geographic atrophy, highlighting a systemic gut/immune/retina axis. #GeographicAtrophy #AMD #Microbiome #Genomics #Ophthalmology #Science buff.ly/7yU87jB
- This is fantastic news from Complement Therapeutics! MHRA CTA approval for CTx001, which will lead to an expansion of the clinical trials into both the US and UK. #FDA #MHRA #clinicaltrials #AMD #IND #compelment #ophthalmology
- New genetic evidence links higher bone mineral density to a lower risk of wet age-related macular degeneration, reframing AMD as a systemic ageing disease, not just an eye disorder. #AMD #VisionResearch #Ageing #Ophthalmology #BoneHealth #Genetics #Science buff.ly/7n1UsRh
- New study shows deleting FHR1 reduces atherosclerosis, inflammation, and plaque formation in mice—revealing a novel immune-lipid axis in cardiovascular disease. #Atherosclerosis #CardioScience #Immunology #ComplementSystem #TranslationalResearch buff.ly/QEVu3ct
- New evidence suggests the retina may reveal Alzheimer’s disease before dementia, with OCT/OCT-A detecting early structural and vascular changes—even preclinically. #Alzheimers #Neurodegeneration #OCT #Biomarkers #EarlyDetection #Neuroscience buff.ly/LLd7n8T
- New study shows ring aperture Retro mode imaging detects pigment migration in AMD with high sensitivity—matching en face OCT and outperforming standard fundus imaging. #AMD #RetinalImaging #Ophthalmology #MedicalImaging #Diagnostics #VisionScience buff.ly/IiLyyjg
- New study shows combining microperimetry with AI-quantified OCT biomarkers captures localized functional loss in geographic atrophy—pointing to more sensitive clinical trial endpoints. #GeographicAtrophy #AMD #Ophthalmology #AIinMedicine #ClinicalTrials buff.ly/DuHs30i
- Prelim Phase 2 data hint Ocugen’s AAV5 gene therapy (OCU410) may outperform approved GA treatments at mid-dose, while higher doses raise intriguing biology questions 👀🧬 #GeneTherapy #DryAMD #GeographicAtrophy #Biotech #ClinicalTrials
- An opportunity for someone to join our team! We're looking for a 50% Technical Assistant from Feb. 2026 - Dec. 2030 Application deadline Today! Please see
- New Cell Reports study moves GWAS from association to causation, using single-cell multiomics to pinpoint causal variants driving macular degeneration. #Genomics #GWAS #CausalVariants #PrecisionMed #AMD #complement buff.ly/w7b7CPU
- Scientific Reports links systemic complement activation to choroidal thinning in advanced non-neovascular AMD, pointing to immune-driven disease #AMD #Ophthalmology #Immunology #BiomedicalResearch #Science buff.ly/1w46ZAn
- A life-changing breakthrough in eye care: a pioneering injection has restored sight and prevented blindness—showing how medical innovation can truly change lives. 👁️✨ #MedicalBreakthrough #EyeHealth #HealthcareInnovation #ScienceForGood #PatientImpact
- An opportunity for someone to join our team! We're looking for a 50% Technical Assistant from Feb. 2026 - Dec. 2030 Application deadline 15th Jan 2026! Please see
- Large-scale pan-cancer analysis identifies Complement Factor H (CFH) as a novel immune-related and prognostic biomarker, linking complement regulation to tumor immunity and patient outcomes. #CancerResearch #ImmunoOncology #Biomarkers #PrecisionMedicine buff.ly/XmlgOQB
- TME Pharma is rethinking its eye drug strategy after losing a key partner, shifting focus to preclinical validation of its novel anti-fibrotic approach in ophthalmology. #Biotech #Ophthalmology #DrugDevelopment #PharmaNews
- Great 2026 news for ocular gene therapy: Ikarovec partners with VectorBuilder to attempt intravitreal delivery of IKAR-003. Nice to see continuing innovation in this challenging space. #GeneTherapy #Ophthalmology #AAV buff.ly/8Ich46b
- A global first in AMD research: the RIMR AMD Consortium unites 100k+ longitudinal OCT scans across continents, unlocking scalable AI-ready insights into disease progression. #AMD #Retina #Ophthalmology #OCT #AIinHealthcare #BigData #VisionScience #MedTech buff.ly/qQNCKQ5
- An opportunity for someone to join our team! We're looking for a 50% Technical Assistant from Feb. 2026 - Dec. 2030 Application deadline 15th Jan 2026! Please see
- A first-in-class nanobody gene therapy enables sustained, intraocular inhibition of complement C3, significantly suppressing pathological neovascularization. #GeneTherapy #AMD #Complement #Nanobodies #Biotech #VisionScience #TranslationalMedicine buff.ly/JaWxxmB
- New TALON Phase IIIb results: brolucizumab enables more nAMD patients to reach 16-week treat-and-extend dosing vs aflibercept, with comparable vision gains—less treatment burden. #nAMD #Retina #Ophthalmology #ClinicalTrials #MedTwitter #VisionResearch buff.ly/OI1TPGZ
- An opportunity for someone to join our team! We're looking for a 50% Technical Assistant from Feb. 2026 - Dec. 2030 Application deadline 15th Jan 2026! Please see
- Aviceda’s glycan-nanoparticle therapy showed biological activity in geographic atrophy despite missing a Phase 2 endpoint. #Biotech #Ophthalmology #DrugDevelopment #ClinicalTrials #Innovation #Biopharma
- New JAMA Ophthalmology study reveals underrecognized maculopathy linked to common systemic drugs, reshaping how we think about retinal risk, drug safety, and cross-disciplinary care. #Ophthalmology #Retina #DrugSafety #MedTwitter #ClinicalResearch
- New research shows that blocking NLRP3 inflammasome activation sharply reduces early AMD-like retinal damage, spotlighting a powerful new avenue for prevention. #AMD #Ophthalmology #NLRP3 #Inflammation #Retina #VisionScience #MedTwitter #SciComm buff.ly/1exc7JR
- New findings reveal IgA nephropathy immune complexes carry a rich complement-protein signature with therapy-responsive markers like FHR1, opening the door to sharper biomarkers and targets. #IgAN #Nephrology #Complement #Biomarkers #Proteomics #MedTwitter buff.ly/GA7gaFq
- Breakthrough AMD study identifies lncRNA HTRA1-AS, not classic complement genes, as the key driver of reticular pseudodrusen, redefining AMD genetics and opening the door to targeted therapies. #AMD #Genomics #HTRA1AS1 #Ophthalmology #PrecisionMedicine buff.ly/sCLS1jV
- New research reveals systemic complement activation, specially elevated Factor B (Bb), is tightly linked to reduced choroidal thickness in advanced nnAMD. #AMD #Ophthalmology #ComplementSystem #Biomarkers #MedTwitter #SciComm #ResearchNews buff.ly/WQP6t8H
- Pleased to share that I will be talking at this year's Complement Based Drug Development Summit 1st-3rd Dec, in Boston US. Join us for the latest developments and future visions for complement therapeutics! buff.ly/RqA9bfm #complement #drugdevelopment #innovation
- Groundbreaking study suggests causal genetic links between the gut microbiome, immune aging, and macular degeneration. #Microbiome #Aging #Immunology #AMD #GutEyeAxis #Genetics #SystemsBiology #PrecisionMedicine #AgingResearch #Bioinformatics buff.ly/VsWMHYP
- New Mendelian randomization study reveals FHR1 and FD as causal drivers in IgA and diabetic nephropathy #Nephrology #KidneyDisease #PrecisionMedicine #Genomics #ComplementSystem #DrugDiscovery #Innovation #ScienceNews #AI #Bioinformatics buff.ly/tfat5dy
- New study identifies genetically prioritised plasma proteins as novel therapeutic targets for dry AMD, inc. FHR-4 and FHR-2 #AMD #Ophthalmology #PrecisionMedicine #Proteomics #Genomics #DrugDiscovery #Innovation #ScienceNews #Bioinformatics buff.ly/Q8oaU1e
- Transferrin supplementation restores iron balance, prevents ferroptosis, and protects retinal cells, implying a novel therapeutic path for dry AMD. #AMD #Retina #Ophthalmology #Ferroptosis #Transferrin #IronMetabolism #Neuroprotection #CellDeathDisease buff.ly/xt4Anvk
- NIH commits $87M to a new Organoid Center—accelerating the shift from animal testing to human-tissue models that could transform drug discovery. #Organoids #DrugDiscovery #Biotech #Innovation #AlternativesToAnimalTesting #TranslationalResearch
- MACUSTAR study links structural biomarkers in intermediate AMD (RPD, cRORA) to pathway-specific polygenic risk scores—advancing precision risk stratification & trial design. #AMD #Ophthalmology #Genetics #PolygenicRisk #PrecisionMedicine #VisionResearch buff.ly/SyjrWEg
- New study reveals a once “uncertain” CFH variant (p.Pro440Ser) is pathogenic in familial cuticular drusen—linking genetics, complement dysregulation & early macular disease. #Ophthalmology #Genetics #AMD #PrecisionMedicine #RareDisease #VisionResearch buff.ly/wnHCeCI
- New study shows #HTRA1 directly disrupts toxic #Tau fibril seeding: a breakthrough in understanding #Alzheimers and opening doors to novel #Neurodegeneration therapies. Understanding HTRA1 biochemistry may unlock what its doing in AMD too. buff.ly/KKyCtNi
- Zinc isn’t just a supplement: it’s a master regulator of retinal health, reshaping our understanding of #AMD, #OxidativeStress & the #GutEyeAxis. #Ophthalmology #Retina #EyeHealth #VisionScience buff.ly/Fvi4Q0H
- Reposted by Simon J. ClarkCongrats to @prof-clark.bsky.social for the 2025 #Svar Complement Excellence Award at ICW Brisbane ! This Award is an annual honor for outstanding international contributions to complement science. 💪👏 @unituebingen.bsky.social @tueneurocampus.bsky.social www.eye-tuebingen.de?tx_news_pi1%...
- Pleased to share that I will be talking at this year's Complement Based Drug Development Summit 1st-3rd Dec, in Boston US. Join us for the latest developments and future visions for complement therapeutics! buff.ly/RqA9bfm #complement #drugdevelopment #innovation
- First-ever use of Adaptive Optics Transscleral Flood Illumination (AO-TFI) reveals 4 distinct retinal phenotypes in AMD, opening new paths for earlier detection and precision monitoring. #AMD #Ophthalmology #AdaptiveOptics #Retina #MedicalImaging buff.ly/FrxgHDX
- It’s a huge honor to receive one of this years SVAR Complement Excellence Award 2025! Thank you so much for this recognition of our work studying ECM-driven immunity! @eye-tuebingen.bsky.social #ICW2025 #AMD #ophthalmology #complement
- This doesn't look good - I remember when Merck committed to a +£1Billion investment in the UK was touted as a Brexit win. Merck executes its own Brexit, moving all R&D operations out of UK
- AI eye scans in GP clinics hit 93% accuracy detecting diabetic retinopathy—real-world proof that accessible, instant screening can transform early detection and patient care. buff.ly/kilZWTi #AI #DigitalHealth #DiabeticRetinopathy #HealthTech #Early
- Striking shifts in FH N-glycans appear in HUS patients without altering core function, raising big questions about whether AMD risk variants might also shape complement glycosylation. #AMD #complement #glycans #glycobiology #risk buff.ly/mPYgbVB
- New real-world data show avacincaptad pegol (Izervay) is safe in GA, with no inflammation or endophthalmitis and only ~6% annual CNV risk—reassuring results beyond clinical trials. #GeographicAtrophy #AvacincaptadPegol #Ophthalmology #RealWorldEvidence #Innovation buff.ly/mSnVtjg
- 🚨 PhD Positions Alert!🚨 Want to join a dynamic initiative between Europe's two leading centres of Ophthalmology? Then apply for a PhD opportunity as part of our Limits2Vision research programme - buff.ly/Ewv0g2k
- New imaging shows hyporeflective clumps in AMD eyes move at microglia-like speeds, unveiling a dynamic biomarker that could transform how we track disease progression. #AMD #Ophthalmology #AdaptiveOptics #Biomarkers #VisionScience buff.ly/4uKVDsE
