PlessLab
Ion channels, biophysics, chemical biology, protein engineering and molecular neuroscience; Professor at University of Copenhagen; www.theplesslab.com
- Reposted by PlessLabSudha (@chakrapanilab.bsky.social) and Julio (@cvlab.bsky.social) are organizing the 2026 Ion Channel Gordon Research Conference: Ion Channels Across Scales — Bridging Molecular Events to Physiological Outcomes, to be held at Mount Holyoke College, July 12–17, 2026. 1/3
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- Time to sign up! Registration for the joint FEBS/EMBO course on ion channels and transporters in Erice, Italy (May 13-19th 2026) is now open: meetings.embo.org/event/26-ion... Please share and repost.
- Reposted by PlessLabLorne Proteins 2026 🏖️ Leach Lecturer Carol Robinson, Oxford, on establishing mass spec as a viable technique for structure/function studies; and John Kuriyan, Vanderbilt University, on the structural plasticity and evolutionary potential of DNA clamp loaders. 🔗 Register now: www.lorneproteins.org
- Reposted by PlessLabA new community-driven lab handbook for reducing conflict and creating more positive and equitable work environments gets strong support from a survey of 200 researchers. buff.ly/K7CGFLV
- To all trainees interested in channels and transporters: the joint FEBS/EMBO course will go ahead in Erice, Italy from May 13-19 2026: network.febs.org/posts/new-jo... Further details to come soon. Please share and repost.
- Reposted by PlessLabPhD students and Postdocs: The Night Science Podcast (@nightsciencepod.bsky.social) is producing an episode highlighting young scientists talking about their creative process. DM me if you'd like us to consider you for this, & read below what PhD student Davis Garner will contribute! ⬇️
- Reposted by PlessLabGame changer, no doubt. Commercial systems will have expensive consumables I suppose, but huge savings to be made in cell culture, and many important but sparse native targets come into play. Crispr-tagged targets from iPSC neurons, for example. TRPC6 blind? 🤯
- MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony. Or from a single dish of HEK cell culture in the case of two membrane proteins. Out in Nature Methods now! lnkd.in/gpyBSceg Wonderful collaboration with the Efremov lab.
- Very grateful to have been able to attend the second-ever NALCN conference. This provided a fantastic opportunity to catch up with collaborators and meet patients and families affected by NALCN-related diseases. Huge thanks to everyone at the Channeling Hope Foundation for making this event happen!
- Reposted by PlessLabPhosphorylation on tyrosines control key pathways in immunity, cancer, and metabolism. For the first time, we can now design proteins that specifically recognize individual phosphotyrosines, even in disordered regions. (1/8) Preprint: www.biorxiv.org/content/10.1...
- When I started working on ion channels 20+ yrs ago, I could have never imagined how many channels there are to explore! Now I’m delighted to be heading to thematic meetings on two of our favorite channels in the span of just weeks - can’t wait to catch up with the ASIC and NALCN communities!
- After years in making, I am glad to be able to share our attempt on establishing a framework for combined functional and computational assessment of variant pathogenicity in the sodium leak channel NALCN: www.biorxiv.org/content/10.1...
- De novo and inherited NALCN variants can lead to severe developmental syndromes. Although variants of uncertain significance or presumed pathogenic variants have been studied in heterologous systems before, there is no generally accepted framework on how to assess or predict variant pathogenicity.
- Reposted by PlessLabMomentum is building! Join us for the 51st Lorne Proteins Conference Feb 8–12, 2026, Mantra Lorne on the Great Ocean Road, for fun networking activities 🏐 🎾 🥗 🪩 and breathtaking surf-coast accessibility 🏖️ 🏊 🏄 in the generous breaks between sessions! 🔗 Register here: www.lorneproteins.org/register
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- Wonderful visit to beautiful Bergen, Norway. Big thanks to @herculeria.bsky.social for hosting and to Tim Lynagh for guiding me up the local hills
- Reposted by PlessLab🥁🥁🥁 The 51st Lorne Conference on Protein Structure and Function is officially live! After the resounding success of the 50th Lorne Conference in 2025 celebrating five decades of pioneering science and community, the legacy continues... 🏄🏖️🌞 February 8–12, 2026 Register here: www.lorneproteins.org
- Reposted by PlessLabFriends don’t use friend’s plasmids without sequencing them. For some types of plasmids from academic and industrial labs, up to 40% contained mutations academic.oup.com/nar/article/...
- Reposted by PlessLabVillum Sabbatical grant: For US-based researchers wishing to visit a Danish university for up to 12 months Deadline Aug. 15th 2025 villumfonden.dk/en/group/cha...
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- “It’s the company that matters!” This is certainly true for acid-sensing ion channel 1a, whose function is modulated by the presence of monocarboxylate transporter 1 All was made possible by the drive & curiosity of the fantastic @mette-h-poulsen.bsky.social www.biorxiv.org/cgi/content/...
- Reposted by PlessLabA major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)
- Applications are now open! We are recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential. 🔗 All positions: ki.se/en/about-ki/...
- Exciting news for protein design!
- New €94M research centre for protein design will open at the University of Copenhagen and be led by Dek Woolfson Funded by the Novo Nordisk Foundation, the centre will operate across the Departments of Biology and & Drug Design and Pharmacology novonordiskfonden.dk/en/news/new-...
- Reposted by PlessLabI guess I should re-post from the Bird Site "The Rules For Academic Success here": I always get asked for advice about starting/surviving the tenure track. Here are the rules I've found useful. Thought I'd put it out there for the masses... This list gets longer all the time
- Reposted by PlessLabThe 3rd Berlin Single Molecule Biophysics Course will run from 8th to 12th September at the HU-Berlin, Institute of Biology. Learn about single channels, single molecule TIRF, theory and analysis. Apply by 7th July at bsmbc@icloud.com. Fee waivers and bursaries available. ! Please share widely !
- Great meeting on acid-sensing ion channels coming up in the fall in Germany - make sure to sign up: www.asic-meeting.org
- Reposted by PlessLab🧵5 Top Free Alternatives to BioRender for Scientific Illustrations! These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs. Save and share the post!
- Reposted by PlessLabCCeMMP Seminar alert⏰ We welcome Professor Juan Du, Department of Molecular Biosciences, Northwestern University, Illinois, USA! “The importance of Physiological Temperature in Biomedical & Biophysical Research” More details and register: ccemmp.org/events/ccemm...
- Very important to keep in mind: Asp/Glu aren’t necessarily always charged!
- You thought Glu/Asp don't like RNA or DNA? Maybe you even introduced them into your protein to stop such interactions? 😱🧪 Think again! New paper @angewandtechemie.bsky.social with Wöhnert lab shows structural context matters for phosphodiester interactions! onlinelibrary.wiley.com/doi/10.1002/...
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- Reposted by PlessLabSave the date!!! For the first time since 2015, the annual conference of the International Chemical Biology Society comes back to Europe and joins forces with the biennal European Chemical Biology Symposium, to organize #ChemBioParis2025, in the heart of the City of Light. Oct 6-9, 2025.
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- Reposted by PlessLabStellar line up for our protein design conference. Copenhagen, Sept 1-4, 2025. 10 days to abstract deadline. Get applying! benzon-foundation.dk/benzon-sympo...
- Reposted by PlessLab⏰ Two weeks left to register for our Benzon Symposium on Protein structure prediction and design 🧶🧬🖥️ Meeting will take place in Copenhagen 🇩🇰 on Sept. 1–4, 2025, and will feature an amazing list of speakers 👨🔬👩🔬👩💻👨💻 Submit your application via: benzon-foundation.dk/benzon-sympo...
- Our latest paper on the sodium leak channel NALCN complex is now online. We found that the neuronal SNARE proteins syntaxin 1A and SNAP25 inhibit sodium leak currents both in heterologous systems and in neurons! www.science.org/doi/10.1126/...
- The study was initiated and led by @samuel.bsky.team, who developed a bioinformatics approach that implicated SNARE proteins as potential interaction partners of the NALCN complex.
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- Very grateful to have been able to attend #BPS2025! Big thanks to everyone involved in making this inspiring event possible! At the same time, the meeting was a stark reminder of how politics can interfere with science - and how cost 💲 is a major discriminator of who can and cannot attend!
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- Reposted by PlessLabOne more sleep to the @biophysicalsoc.bsky.social CRT Symposium on tomorrow morning bright and early! Join us in Petree Hall C at 8.30am.
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- Just touched down in LA for #BPS2025 - excited to be here and looking forward to catching up with friends and colleagues!
- Nothing like hearing about an exciting result from the lab after a long week of teaching!
- Reposted by PlessLabReminder that @europepmc.org is a mirror of Pubmed with better search and that it indexes *all* bioRxiv preprints (as well as ResearchSquare), not just the ones funded by NIH like chauvinist Pubmed
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- Reposted by PlessLabThe Channels, Receptors & Transporters Subgroup of the @biophysicalsoc.bsky.social is excited to announce the final program for our 2025 Symposium. Please join us on Feb 15 to hear from @willowcoyote.bsky.social @drcontrexin.bsky.social @corrylab.bsky.social and others 👇Thanks to our sponsors!
- Reposted by PlessLabCome to Copenhagen
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- Reposted by PlessLabWant to come work with me? Short postdoc opportunity. Deadline tomorrow ⚡️ jobportal.ku.dk/videnskabeli...
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- This is bizarre. I wonder what prompted this decision. Especially in light of universities and funding bodies around the globe heading in exactly the opposite direction (and for good reason!). Luckily, there’s a German word for this: ‘weltfremd’ (out of touch with the world/reality)
- Over 100 German Universities Partner with #MDPI in New National Agreement
- Congratulations to the awardees!
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- I like doing science. I like talking science. I do NOT like dealing with all those wild journal rules and regulations.
- Reposted by PlessLab1. I feel like this is such obvious advice that it gets taken for granted & consequently no one says this to young scientists but READ PAPERS, read all the papers. As you move up in your career you will have less & less time to do this. Read everything that appeals to you not just in your field
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- Grateful for having contributed to this work by the Isabelle Baconguis group, who solved eleven (!) new structures of hASIC1a to show that open states require linear transmembrane helices, while desensitized states display a dazzling structural diversity www.biorxiv.org/content/10.1... #ionchannels
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