Phil Holliger
Program Leader and Head of PNAC division at MRC Laboratory of Molecular Biology, Cambridge, UK @mrclmb.bsky.social. Synthetic / Chemical biology and all things RNA
- Reposted by Phil Holliger[Not loaded yet]
- Reposted by Phil HolligerExcited to share our latest work on dissecting the mechanism of processive telomeric DNA synthesis by telomerase. Led by amazing PhD student Sebastian Balch in collaboration with lab members,@automnenine.bsky.social @rachael-kretsch.bsky.social,@rdaslab.bsky.social. www.nature.com/articles/s41...
- Reposted by Phil Holliger[Not loaded yet]
- Reposted by Phil Holliger🌐Our new LMB website is live!🌐 Fresh design, better navigation, same first-class science. Take a look around ➡️ mrclmb.ac.uk
- Reposted by Phil HolligerI wrote some personal reflections about being physically embedded in a world-leading molecular biology lab @mrclmb.bsky.social, learning to communicate with experimentalists, back-breaking wet lab work, scientific rigour, and skin in the game! 💌: chaitjo.substack.com/p/an-ai-rese...
- Reposted by Phil HolligerExcited to release the fully open-source code for gRNAde - our wet-lab validated, generative AI framework for 3D RNA inverse design 🚀⭐️ I pride myself on open-science & this is probably the most intense release I've done!
- Reposted by Phil HolligerTime for a new pre-print! How do dendritic cells control pore formation in their own endocytic compartments? Our work shows that the unique transmembrane anchor of perforin-2 does not protect DC membranes, but instead it enables antigen escape during cross-presentation doi.org/10.64898/202...
- Reposted by Phil HolligerA key step towards human genome synthesis. With thanks to @wellcometrust.bsky.social @mrclmb.bsky.social #SynHG doi.org/10.1126/scie...
- Reposted by Phil Holliger[Not loaded yet]
- Reposted by Phil Holliger[Not loaded yet]
- Reposted by Phil HolligerGreat culture can save lives. Literally. Amazing letter in today’s @thetimes.com about Tom Stoppard
- Reposted by Phil HolligerCongratulations to @anatv.bsky.social, Group Leader in the LMB’s PNAC Division, who has joined @embo.org’s Young Investigator Programme! Read more about the programme and Ana’s research here: www2.mrc-lmb.cam.ac.uk/ana-tufegdzi... #LMBNews
- Reposted by Phil HolligerPilar raises her Asgard bridge from the sea!
- Reposted by Phil HolligerIntroducing gRNAde: our own little "AlphaGo Moment" for RNA design! 🧬🚀 📝: tinyurl.com/gRNAde-paper Unlike proteins, RNA design has long relied on "wisdom of the crowd" (human experts) or the slow crawl of directed evolution — gRNAde changes that! 🧵👇
-
View full threadReposted by Phil Holliger4/ This was a massive team effort bridging AI and biology, from one end of Cambridge to another 🤗🚲 Thanks to Edo Gianni* @edogia.bsky.social, Sam Kwok*, @simonmathis.bsky.social, Pietro Liò, and @philholliger.bsky.social for this journey! 📄 Preprint: tinyurl.com/gRNAde-paper
- Reposted by Phil HolligerWhat do apple trees, Nobel Prizes, cows, and world-changing innovation all have in common? Well, they're all part of a new animated journey across one of Europe’s most extraordinary places, the Cambridge Biomedical Campus. youtu.be/2K7Txdwb_k4
- Reposted by Phil Holliger[Not loaded yet]
- Reposted by Phil HolligerCongratulations to the 2025 recipients of the Perutz Student Prize and the Joan Steitz Postdoc Prize: Claudia De Miguel, @lucaschwarz.bsky.social, Tom Dendooven, Sofia Lövestam, Katerina Naydenva & Tomke Stürner. Find out why they won here: www2.mrc-lmb.cam.ac.uk/lmb-prizes-2... #LMBNews 👏
- Reposted by Phil HolligerRewriting the language of life: Jason Chin’s group in the LMB’s PNAC Division have synthesised E. coli with just 57 codons instead of the usual 64. Syn57 required 101000+ codon changes & represents a bold step towards programmable life. Read more: www2.mrc-lmb.cam.ac.uk/syn57-repres... #LMBResearch🧪
- Reposted by Phil Holliger[Not loaded yet]
- We are looking to recruit a tenure track group leader in the field of Chemical/Synthetic Biology (in the broadest sense) to lead a research program within the Division of Protein & Nucleic Acid Chemistry ( www.jobs.ac.uk/job/DNW809/r... ) at the MRC Laboratory of Molecular Biology (LMB).
- Reposted by Phil Holliger[Not loaded yet]
- Reposted by Phil HolligerExcited to share our latest work! We found transcription factor SPT6 and phosphorylated Pol II CTD help recruit U1 snRNP to elongating Pol II, allowing efficient co-transcriptional splicing. Glad to be featured in the Editors’ Highlights! www.nature.com/articles/s41... #splicing #cryoEM
- Reposted by Phil HolligerHighly collaborative efforts that involved 6 lab members and the labs of @yiliangding.bsky.social and @rdaslab.bsky.social. We uncovered a telomerase dimer and its potential role in telomere maintenance.
- Sebastian Balch, Zala Sekne & Elsa Franco-Echevarría in @kellythd-nguyen.bsky.social's group have confirmed the existence of dimeric telomerase and illustrated how it is key to telomere maintenance: www2.mrc-lmb.cam.ac.uk/first-struct... #LMBResearch @yiliangding.bsky.social @rdaslab.bsky.social 🧪
- Reposted by Phil Holliger[Not loaded yet]
- Reposted by Phil Holliger[Not loaded yet]
- Reposted by Phil HolligerCongratulations to @tbharat-lab.bsky.social, Group Leader in the LMB’s Structural Studies Division, who has received the Gold Medal from @embo.org for his research on prokaryotic surface molecules. Read more here: www2.mrc-lmb.cam.ac.uk/tanmay-bhara... #LMBNews
- Reposted by Phil Holliger[Not loaded yet]
- Reposted by Phil Holliger[Not loaded yet]
- Reposted by Phil HolligerHow did life on Earth begin? 🌍🧬 New #LMBResearch from Phil Holliger’s group, including James Attwater (now @uclchemistry.bsky.social @uclnews.bsky.social) shows how pH-freeze-thaw cycles enables RNA self-replication, overcoming a key evolutionary hurdle. Read more: www.ucl.ac.uk/news/2025/ma...
