How does the structure of a neural circuit shape its function? @neuralreckoning.bsky.social & I explore this in our new preprint: doi.org/10.1101/2025... 🤖🧠🧪 🧵1/9

Looks very cool. You say "Second, to isolate how each pathway changes network function, we compare pairs of circuits which differ by one pathway." Useful to look as pairwise and n-wise changes to understand possible "nonlinear" effects? I didn't go back to check if the combinatorics are feasible.

Thanks! We focussed on pairwise differences for interpretability, but you're right it would be interesting to look at n-wise changes too. And actually, even exploring up to the maximum difference does seem feasible! Something to include in the revised version.

But then that's important to know right? After all we're too wedded to the idea of single differences. For example, let's investigate the brain one lesion at at time, or one lesion plus a control one and so on.