Idoyaga and colleagues suggest that pDCs can lose the ability to secrete IFN-I and acquire the transcriptional, epigenetic and functional features of cDCs. Read it here:
rdcu.be/eBB5e
www.nature.com/articles/s41...
TNF and type I interferon crosstalk controls the fate and function of plasmacytoid dendritic cells
Nature Immunology - Plasmacytoid dendritic cells are type 1 interferon (IFN-I)-producing antiviral specialists that have been shown to be able to differentiate into conventional dendritic cells....
