Klein and colleagues find that cathepsin L shapes CD4+ T cell selection by promoting full repertoire diversity and fine-tuning CD4+ T cell functionality. Read it here:
rdcu.be/etDy2
www.nature.com/articles/s41...
Cathepsin L-dependent positive selection shapes clonal composition and functional fitness of CD4+ T cells
Nature Immunology - Klein and colleagues show that the lysosomal cysteine protease cathepsin L shapes the diversity and optimizes the fitness of clones that enter the CD4+ T cell repertoire.
