Fang and colleagues find that succinate can suppress Foxp3 expression and enhance colitis severity. Read it here:
rdcu.be/etDuE
www.nature.com/articles/s41...
Succinate drives gut inflammation by promoting FOXP3 degradation through a molecular switch
Nature Immunology - Fang and colleagues show that the metabolite succinate can inhibit succinylation, and consequently protection from ubiquitin-mediated degradation, of the transcription factor...
