Sanders et al find that T cells in the tumor can take up adenosine via ENT1 and this suppresses their anti-tumor response, ENT1 inhibition combined with anti-PD1 could control tumor growth in models resistant to immune checkpoint blockade. Read it here:
rdcu.be/elTq8
www.nature.com/articles/s41...
Inhibition of ENT1 relieves intracellular adenosine-mediated T cell suppression in cancer
Nature Immunology - Metabolites in the tumor microenvironment, including adenosine, have been shown to suppress anti-tumor immune responses. Here, the authors show that T cell expression of...
