- How does subthalamic activity relate to Parkinson’s disease symptoms? In a truly collaborative effort across #DBS centers, we aggregated a diverse dataset of invasive recordings from 119 patients. Full article: doi.org/10.1101/2025... Main findings 🧵⬇️
- #Reproducibility analysis: ↳ Levodopa modulates theta more strongly than beta oscillations. ↳ Beta does not consistently correlate with symptoms in single datasets. ↳ Replicating previous correlations requires cohorts of over 100 patients.May 2, 2025 08:16
- #Powerspectrum analysis: ↳ Absolute power provides clearer insights than normalized power. ↳ Separating oscillations from the broadband improves interpretability. ↳ Theta & Low β & Low 𝛄 combined explained symptom severity better than beta alone.
- #Aperiodic broadband power: ↳ Likely indicates neuronal spiking. ↳ Reflects symptom severity within patients. ↳ Shows promise as a biomarker for adaptive deep brain stimulation.
- I am deeply grateful to @julianneumann.bsky.social, @vlitvak.bsky.social, @ashwinioswal.bsky.social, Alfons Schnitzler, Esther Florin, Andrea Kühn, Jan Hirschmann, and Huiling Tan for sharing data and expertise, enabling me to synthesize their decades of experience into this work.
- I am sincerely grateful to my supervisors–Vadim Nikulin, Gabriel Curio, Gunnar Waterstraat, and Arno Villringer–for their consistent support, guidance, and for shaping my approach to rigorous scientific work.
